Impact of celiace disease on reproductive performance of women
Keywords:
Celiac disease, reproductive performance, malabsorption, embryogenesis, menarche, gynecological, obstetric disorder, infertility, stillbirth, early menopauseAbstract
Celiac disease is an incurable disease caused by a failure of the human body in digesting ingested gluten causing immunological mediated provocative impairment of small- intestinal mucosa. As against classical presentation for diarrhea and abnormal absorption of nutrients from digestive tract, which were earlier more evident, now a spike is noticed in the atypical and silent presentations. The disease prevails to the account of 0.5% to 1% in the western Indian population and Arabic population. The bona fide learnedness about different signs and exposures is essential to give rise to prognosis. Only treatment of Celiac disease is lifelong avoidance of gluten from the diet. The disease is reported to affect women during their productive period and often malabsorption interferes with embryogenesis and foetal nutritional status, growth and development. The celiac disorder has also been associated with various gynaecological and obstetric disorders like late menarche, early age menopause, infertility, intrauterine growth retardation, repetitive miscarriage as well as stillbirth in the recent past. In this narrative review, factors leading to the reproductive function of women with celiac disease can be vividly identified. This review gives valuable insight into the association between celiac disease, nutritional deficiency and reproductive performance of women.
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