Relationship of anti-thyroid peroxidase antibody enzyme to antioxidant and lipid level in women with thyroid diseases

Razan N. Shaker; Nawal Th. Younis

doi:10.53730/ijhs.v6nS1.6297

Authors

Razan N. Shaker Departement of chemistry ,Collage of Education for Pure Sciences,University of Mosul, Mosul, Iraq
Nawal Th. Younis
dr.nawal.thanoon@uomosul.edu.iq
Departement of chemistry, Collage of Education for Girls, University of Mosul, Mosul, Iraq

Keywords:

TPO enzyme, dyslipidemia, antioxidant, BMI, thyroid disease

Abstract

The research involved study the relation between thyroid peroixdase (TPO) and some of the measured biochemical parameters reduced glutathione (GSH), arylesterase (ARE), ceruloplasmin, malondialdehyde, cholesterol, triglyceride, LDL, VLDL, HDL, atherogenic index)in serum blood patients compared with control group, the result demonstration is a significant increase in the activity of TPO enzyme(112.63± 69.5 Iu/ml), (273.9±235.1 Iu/ml) in hyperthyroidisum and hypothyroidisum patient respectively compared with activity in control group was( 33.9 ±18.99 Iu/ml), also the results showed the significant increase in the concentration of (HDL), significant decrease in (GSH, ARE enzymes, cholestero, LDL, atherogenic index) and while a non significant increase in (ceruloplasmin,malondialdehyde), non significant decrease in(triglyceride, VLDL) in hyperthyroidism, also the results had been shown a significant increase in (malondialdehyde, triglyceride, VLDL), and a significant decrease in (GSH, ARE enzymes) while a non significant increase in (ceruloplasmin, cholesterol, LDL, atherogenic index) and a non significant decrease in (HDL) in hypothyroidism, Correlation coefficient of TPO enzyme with these clinical parameters showed a positive significant correlation with (GSH enzyme)in control group and with (HDL) in hyperthyroidism while the results showed that there is no significant correlation between TPO enzyme with the rest of boichemical parameters (GSH enzyme).

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