Evaluating the haematological and inflammatory markers in predicting the clinical outcome of COVID-19 patients admitted in a tertiary care hospital of Northern India
Keywords:
SARS-CoV-2, COVID-19, coagulopathy, markers of infection and inflammation, correlationAbstract
Infection with the SARS-CoV-2 virus induces coagulation and stimulates the innate immune system. In ICU patients with COVID-19, nothing is known regarding coagulopathy and the response of inflammation and infection. The effects of SARS-CoV-2 infection on coagulation, infection, and inflammatory indicators, as well as their relationships, were studied. The study took place in Naraina Medical College and Research Centre, a dedicated COVID-19 referral hospital in Northern India, from April to August 2021. This study only included COVID-19 positive hospitalised cases with RT-PCR confirmation. All blood samples were examined for haematological, coagulation, and inflammatory indicators, and mean results were compared between the three patient groups. All patients had elevated d-dimer and FDP levels, notably non-survivors, who had prolonged PT, APTT, INR, and TT, as well as lower PTA and AT, as compared to survivors. Non-survivors were more likely to develop SIC and DIC. All patients' CRP, ESR, serum ferritin, IL-8, and IL-2R levels increased.
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References
Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patientswith pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733.
Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan,China,ofnovelcoronavirus-infectedpneumonia.NEnglJMed.2020;382(13):1199–1207.
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of criticallyill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered,retrospective,observationalstudy.LancetRespirMed.2020;8(5):475–481.
TangN,BaiH,ChenX,GongJ,LiD,SunZ.Anticoagulanttreatment is associated with decreased mortality in severe coronavirusdisease 2019 patients with coagulopathy. J Thrombosis Haemostasis.2020.
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters areassociated with poor prognosis in patients with novel coronaviruspneumonia.JThrombosisHaemostasis.2020;18:844–847.
HeroldT,Jurinovic V,ArnreichC,et al.LevelofIL-6 predictsrespiratory failure in hospitalized symptomatic COVID-19 patients.medRxiv.2020;2020.04.01.20047381.
Qin C, Zhou L, Hu Z, et al. Dysregulation of immune response inpatientswithCOVID-19inWuhan,China.ClinInfectDis.2020.
Liu J, Li S, Liu J, et al. Longitudinal characteristics of lymphocyteresponses and cytokine profiles in the peripheral blood of SARS-CoV-2infectedpatients.medRxiv.2020.
LeviM,vanderPollT.Coagulationandsepsis.ThrombRes.2017;149:38–44.
Patel P, Walborn A, Rondina M, Fareed J, Hoppensteadt D. Markersof inflammation and infection in sepsis and disseminated intravascu-larcoagulation.ClinApplThrombosisHemostasis.2019;25:107.
Lippi G. Sepsis biomarkers: past, present and future. Clin Chem LabMed.2019;57:1281–1283.
ZhouF,YuT,DuR,etal.Clinicalcourseandriskfactorsformortality of adult inpatients with COVID-19 in Wuhan, China: aretrospectivecohortstudy.Lancet.2020;395:1054–1062.
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