Transmission features of Mycobacterium leprae throughout the decline of leprosy incidence
A systematic review
Keywords:
transmission, mycobacterium, leprae, leprosy, incidenceAbstract
Background: Mycobacterium leprae causes leprosy, an infectious disease. As the incidence of the disease declines, the characteristics of new cases begin to diverge from those seen in highly endemic locations, offering potentially valuable insights into ongoing transmission sources. We wanted to see if undiagnosed and untreated new leprosy cases in the community drive transmission more than incompletely treated or relapsing cases. Principle findings/methodology: In January of 2020, a literature search of major electronic databases yielded 134 articles out of 4318 total entries found (PROSPERO ID: CRD42020178923). We presented quantitative data from leprosy case records, along with supporting evidence, to describe the drop in incidence in a variety of settings. The major measures used by countries that achieved a significant reduction in incidence included BCG vaccination, active case detection, adherence to combination therapy, and continuous surveillance after treatment. In a study of 3950 leprosy case data from 22 low-endemic nations, 48.3% were thought to be imported, beginning from transmission outside the country. With 122 cases of suspected relapse from earlier leprosy treatment, the majority of cases (64.4%) were multibacillary and frequently verified with skin biopsy.
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References
World Health Organization. Weekly epidemiological record. Global leprosy update, 2019. 2020; Avail- able from:
Smith CS, Noordeen SK, Richardus JH, Sansarricq H, Cole ST, Baruaf S, et al. A strategy to halt lep- rosy transmission. Lancet Infect Dis. 2014; 14:96–98. https://doi.org/10.1016/S1473-3099(13)70365- 7 PMID: 24457165
Han XY, Seo YH, Sizer KC, Schoberle T, May GS, Spencer JS, et al. A new Mycobacterium species causing diffuse lepromatous leprosy. Am J Clin Pathol. 2008; 130:856–864. https://doi.org/10.1309/ AJCPP72FJZZRRVMM PMID: 19019760
Bratschi MW, Steinmann P, Wickenden A, Gillis TP. Current knowledge on Mycobacterium leprae transmission: a systematic literature review. Lepr Rev. 2015; 86:142–155. PMID: 26502685
Tio´-Coma M, Sprong H, Kik M, van Dissel JT, Han X, Pieters T, et al. Lack of evidence for the pres- ence of leprosy bacilli in red squirrels from North-West Europe. Transbound Emerg Dis. 2020; 67:1032–1034. https://doi.org/10.1111/tbed.13423 PMID: 31733134
Ploemacher T, Faber WR, Menke H, Rutten V, Pieters T. Reservoirs and transmission routes of lep- rosy; A systematic review. PLoS Negl Trop Dis. 2020; 14:1–27. https://doi.org/10.1371/journal.pntd. 0008276 PMID: 32339201
Hockings KJ, Mubemba B, Avanzi C, Pleh K, Dux A, Bersacola E, et al. Leprosy in wild chimpanzees. BioRxiv [Preprint]. 2020 bioRxiv 374371 [posted 2020 Nov 11]. Available from: https://www.biorxiv. org/content/10.1101/2020.11.10.374371v1.full
Smith W. C., van Brakel W., Gillis T., Saunderson P., & Richardus J. H. (2015). The missing millions: a threat to the elimination of leprosy. PLoS Negl Trop Dis, 9(4), e0003658. https://doi.org/10.1371/ journal.pntd.0003658 PMID: 25905706
Meima A, Richardus JH, Habbema JDF. Trends in leprosy case detection worldwide since 1985. LeprRev. 2004; 75:19–33. PMID: 15072123
Richardus JH, Ignotti E, Smith WCS. 18 September 2016, posting date. Epidemiology of leprosy,Chapter 1.1. In Scollard DM, Gillis TP (ed), International textbook of leprosy. www. internationaltextbookofleprosy.org.
Irgens LM. Leprosy in Norway. An epidemiological study based on a national patient registry. LEPRREV. 1980; 51. PMID: 7432082
Irgens L. M., Melo F. C., & Lechat MF. Leprosy in Portugal 1946–80: epidemiologic patterns observed during declining incidence rates. Leprosy review. Lepr Rev. 1990; 32–49. https://doi.org/10.5935/ 0305-7518.19900005 PMID: 2319900
Huan-Ying L, Yu-Lin P, Yang W. Leprosy control in Shandong Province, China, 1955– 1983; some epi- demiological features. INT J LEPR. 1985; 53:79–85. PMID: 3998564
Sales AM, De Leon AP, Du¨ ppre NC, Hacker MA, Nery JA, Sarno EN, et al. Leprosy among patient contacts: a multilevel study of risk factors. PLoS Negl Trop Dis. 2011 Mar 15; 5(3):e1013. https://doi. org/10.1371/journal.pntd.0001013 PMID: 21423643
Moet FJ, Pahan D, Schuring RP, Oskam L, Richardus JH. Physical distance, genetic relationship, age, and leprosy classification are independent risk factors for leprosy in contacts of patients with lep- rosy. J Infect Dis. 2006; 193:346–353. https://doi.org/10.1086/499278 PMID: 16388481
Vijayakumaran P, Jesudasan K, Mozhi NM, Samuel JDR. Does MDT arrest transmission
of leprosy to household contacts? Int J Lepr other Mycobact Dis. 1998; 66:125. PMID: 9728444
PRISMA [Internet]. Available from: http://www.prisma-statement.org/
Kumar B, Uprety S, Dogra S. 9 February 2017, posting date. Clinical diagnosis of leprosy, Chapter
In Scollard DM, Gillis TP (ed), International textbook of leprosy. www. internationaltextbookofleprosy.org.
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