Evaluation of anti-diabetic activity of aqueous and alcoholic extract citrullus colocynthis and trigonella foenum graceum in STZ induced diabetes in rats

Mahesh Kumar Sharma; Pankaj Kumar Sharma; Jaya Sharma

doi:10.53730/ijhs.v6nS3.6584

Authors

Mahesh Kumar Sharma PhD. Research Scholar, School of Pharmacy, Apex University, Jaipur
Pankaj Kumar Sharma Professor, and Dean, School of Pharmacy, Apex University, Jaipur
Jaya Sharma Professor, School of Pharmacy, Apex University, Jaipur

Keywords:

diabetes mellitus, streptozotocin, citrullus colocynthis, trigonella foenum graceum, hypoglycemic effect

Abstract

The aim of this study was to assess the effects of Aqueous and Alcoholic Extract Citrullus Colocynthis and Trigonella Foenum Graceum in different ratio through biochemical factors and histopathological changes in streptozotocin-induced diabetic rats. The current experimental study was performed on 48 male rats, which became diabetic with 60 mg/kg body weight intraperitoneal injection of streptozotocin (STZ). The animals were divided into eight groups: untreated diabetic and diabetic treated with alcoholic and aqueous extract, respectively. The animals were treated with different ratio (i.e. 25:75, 50:50, 75:25) of both alcoholic and aqueous extract of Citrullus Colocynthis and Trigonella Foenum Graceum orally for 14 days. The results indicated that blood sugar, OGTT level shows significantly decrease in alcoholic extract of Citrullus Colocynthis and Trigonella Foenum Graceum (50:50) in diabetic rats treated with the extract compared to the other groups. Histopathological findings showed STZ-induced diabetic complications in the pancreas were improved following treatment with aqueous and alcoholic extract of C. colocynthis and Trigonella Foenum Graceum.

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