Developing new treatment modalities from poorly dissolvable antihypertensive
Courtesy delivery system design &niche technologies
Keywords:
poor solubility, ternary dispersion, amorphization, nano-suspension, nano-particles, antihypertensive, SEDDS, SNEDDS, spinAbstract
Most antihypertensive drugs have impaired dissolution rate and result from poorly aqueous solubility, polymorphic modifications, structure-based H-bond donor or acceptor anamolies. These physical attributes would have detrimental effects and may cause an entity out of the race from efficacious candidates. Nevertheless, compliance with the dissolution rate must be fulfilled under the regulatory mandate and serve as an assessment tool for product performance. The present reviews the niche technologies like electrospinning, spraying, or mesoporous methods that led to the generation of more dissolvable antihypertensives. Several drug delivery systems design allows the incorporation of surfactants, microenvironment dissolution rate modifiers, acidifiers that could improve the dissolution rate of antihypertensives are reviewed.
Downloads
References
Ahuja, B. K., Jena, S. K., Paidi, S. K., Bagri, S., & Suresh, S. (2015). Formulation, optimization and in vitro–in vivo evaluation of febuxostat nanosuspension. International journal of pharmaceutics, 478(2), 540-552.
Alhasani, K. F., Kazi, M., Ibrahim, M. A., Shahba, A. A., & Alanazi, F. K. (2019). Self-nano emulsifying ramipril tablets: A novel delivery system for the enhancement of drug dissolution and stability. International journal of nanomedicine, 14, 5435.
Amarjargal, A., Brunelli, M., Fortunato, G., Spano, F., Kim, C. S., & Rossi, R. M. (2019). On-demand drug release from tailored blended electrospun nanofibers. Journal of Drug Delivery Science and Technology, 52, 8-14.
Amidon, G. L., Lennernäs, H., Shah, V. P., & Crison, J. R. (1995). A theoretical basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmaceutical Research, 12(3), 413-420.
Arafa, M. F., El-Gizawy, S. A., Osman, M. A., & El Maghraby, G. M. (2018). Xylitol as a potential co-crystal co-former for enhancing dissolution rate of felodipine: preparation and evaluation of sublingual tablets. Pharmaceutical development and technology, 23(5), 454-463.
Arun, J. K., Vodeti, R., Shrivastava, B., & Bakshi, V. (2020). Integrated Quality by Design Approach for Developing Nanolipidic Drug Delivery Systems of Olmesartan Medoxomil with Enhanced Antihypertensive Action. Advanced pharmaceutical bulletin, 10(3), 379.
Attari, Z., Bhandari, A., Jagadish, P. C., & Lewis, S. (2016). Enhanced ex vivo intestinal absorption of olmesartan medoxomil nanosuspension: Preparation by combinative technology. Saudi pharmaceutical journal, 24(1), 57-63.
Beg, S., Rahman, M., Panda, S. K., Alharbi, K. S., Alruwaili, N. K., Singh, P. K., ... & Singh, B. (2021). Nasal mucoadhesive microspheres of lercanidipine with improved systemic bioavailability and antihypertensive activity. Journal of Pharmaceutical Innovation, 16(2), 237-246.
Beg, S., Swain, S., Singh, H. P., Patra, C. N., & Rao, M. B. (2012). Development, optimization, and characterization of solid self-nanoemulsifying drug delivery systems of valsartan using porous carriers. Aaps Pharmscitech, 13(4), 1416-1427.
Benet, L. Z., Broccatelli, F., & Oprea, T. I. (2011). BDDCS applied to over 900 drugs. The AAPS Journal, 13(4), 519-547.
Biswas, N. (2017). Modified mesoporous silica nanoparticles for enhancing oral bioavailability and antihypertensive activity of poorly water soluble valsartan. European Journal of Pharmaceutical Sciences, 99, 152-160.
Bolourchian, N., Talamkhani, Z., & Nokhodchi, A. (2019). Preparation and physicochemical characterization of binary and ternary ground mixtures of carvedilol with PVP and SLS aimed to improve the drug dissolution. Pharmaceutical development and technology, 24(9), 1115-1124.
Borba, P. A. A., Pinotti, M., de Campos, C. E. M., Pezzini, B. R., & Stulzer, H. K. (2016). Sodium alginate as a potential carrier in solid dispersion formulations to enhance dissolution rate and apparent water solubility of BCS II drugs. Carbohydrate polymers, 137, 350-359.
Boyd, B. J., Bergström, C. A., Vinarov, Z., Kuentz, M., Brouwers, J., Augustijns, P., ... & Jannin, V. (2019). Successful oral delivery of poorly water-soluble drugs both depends on the intraluminal behavior of drugs and of appropriate advanced drug delivery systems. European Journal of Pharmaceutical Sciences, 137, 104967.
Chai, R., Gao, H., Ma, Z., Guo, M., Fu, Q., Liu, H., & He, Z. (2019). In Vitro and In Vivo Evaluation of Olmesartan Medoxomil Microcrystals and Nanocrystals: Preparation, Characterization, and Pharmacokinetic Comparison in Beagle Dogs. Current drug delivery, 16(6), 500-510.
Chen, H., Wan, J., Wang, Y., Mou, D., Liu, H., Xu, H., & Yang, X. (2008). A facile nano aggregation strategy for oral delivery of hydrophobic drugs by utilizing acid–base neutralization reactions. Nanotechnology, 19(37), 375104.
Chen, Y., Li, L., Yao, J., Ma, Y. Y., Chen, J. M., & Lu, T. B. (2016). Improving the solubility and bioavailability of apixaban via apixaban–oxalic acid cocrystal. Crystal Growth & Design, 16(5), 2923-2930.
Chung, P., Heller, J. A., Etemadi, M., Ottoson, P. E., Liu, J. A., Rand, L., & Roy, S. (2014). Rapid and low-cost prototyping of medical devices using 3D printed molds for liquid injection molding. Journal of visualized experiments: JoVE, (88).
Contreras-Cáceres, R., Cabeza, L., Perazzoli, G., Díaz, A., López-Romero, J. M., Melguizo, C., & Prados, J. (2019). Electrospun nanofibers: Recent applications in drug delivery and cancer therapy. Nanomaterials, 9(4), 656.
Dai, X. L., Li, S., Chen, J. M., & Lu, T. B. (2016). Improving the membrane permeability of 5-fluorouracil via cocrystallization. Crystal Growth & Design, 16(8), 4430-4438.
Detroja, C., Chavhan, S., & Sawant, K. (2011). Enhanced antihypertensive activity of candesartan cilexetil nanosuspension: formulation, characterization and pharmacodynamic study. Scientia pharmaceutica, 79(3), 635-652.
Dinnebier, R. E., Sieger, P., Nar, H., Shankland, K., & David, W. I. (2000). Structural characterization of three crystalline modifications of telmisartan by single crystal and high‐resolution X‐ray powder diffraction. Journal of pharmaceutical sciences, 89(11), 1465-1479.
Ditzinger, F., Scherer, U., Schönenberger, M., Holm, R., & Kuentz, M. (2018). Modified polymer matrix in pharmaceutical hot melt extrusion by molecular interactions with a carboxylic coformer. Molecular pharmaceutics, 16(1), 141-150.
Duggirala, N. K., Perry, M. L., Almarsson, Ö., & Zaworotko, M. J. (2016). Pharmaceutical cocrystals: along the path to improved medicines. Chemical communications, 52(4), 640-655.
Dzenis, Y. (2004). Spinning continuous fibers for nanotechnology. Science, 304(5679), 1917-1919.
Fares, A. R., ElMeshad, A. N., & Kassem, M. A. (2018). Enhancement of dissolution and oral bioavailability of lacidipine via pluronic P123/F127 mixed polymeric micelles: formulation, optimization using central composite design and in vivo bioavailability study. Drug delivery, 25(1), 132-142.
Farkas, B., Balogh, A., Farkas, A., Marosi, G., & Nagy, Z. K. (2020). Frequency and waveform dependence of alternating current electrospinning and their uses for drug dissolution enhancement. International Journal of Pharmaceutics, 586, 119593.
Franca, M. T., Pereira, R. N., Riekes, M. K., Pinto, J. M. O., & Stulzer, H. K. (2018). Investigation of novel supersaturating drug delivery systems of chlorthalidone: The use of polymer-surfactant complex as an effective carrier in solid dispersions. European Journal of Pharmaceutical Sciences, 111, 142-152.
Gao, L., Zhang, D., & Chen, M. (2008). Drug nanocrystals for the formulation of poorly soluble drugs and its application as a potential drug delivery system. Journal of Nanoparticle Research, 10(5), 845-862.
Giri, B. R., Kwon, J., Vo, A. Q., Bhagurkar, A. M., Bandari, S., & Kim, D. W. (2021). Hot-Melt Extruded Amorphous Solid Dispersion for Solubility, Stability, and Bioavailability Enhancement of Telmisartan. Pharmaceuticals, 14(1), 73.
Gora, S., Mustafa, G., Sahni, J. K., Ali, J., & Baboota, S. (2016). Nanosizing of valsartan by high pressure homogenization to produce dissolution enhanced nanosuspension: pharmacokinetics and pharmacodyanamic study. Drug delivery, 23(3), 930-940.
Guan, J., Huan, X., Liu, Q., Jin, L., Wu, H., Zhang, X., & Mao, S. (2019). Synergetic effect of nucleation and crystal growth inhibitor on in vitro-in vivo performance of supersaturable lacidipine solid dispersion. International journal of pharmaceutics, 566, 594-603.
Guan, J., Jin, L., Liu, Q., Xu, H., Wu, H., Zhang, X., & Mao, S. (2019). Exploration of supersaturable lacidipine ternary amorphous solid dispersion for enhanced dissolution and in vivo absorption. European Journal of Pharmaceutical Sciences, 139, 105043.
Halder, S., Ogino, M., Seto, Y., Sato, H., & Onoue, S. (2018). Improved biopharmaceutical properties of carvedilol employing α-tocopheryl polyethylene glycol 1000 succinate-based self-emulsifying drug delivery system. Drug development and industrial pharmacy, 44(11), 1838-1844.
Han, D., Serra, R., Gorelick, N., Fatima, U., Eberhart, C. G., Brem, H., ... & Steckl, A. J. (2019). Multi-layered core-sheath fiber membranes for controlled drug release in the local treatment of brain tumor. Scientific reports, 9(1), 1-12.
Haneef, J., Arora, P., & Chadha, R. (2020). Implication of Coformer Structural Diversity on Cocrystallization Outcomes of Telmisartan with Improved Biopharmaceutical Performance. AAPS PharmSciTech, 21(1), 1-11.
Hate, S. S., Reutzel-Edens, S. M., & Taylor, L. S. (2018). Insight into amorphous solid dispersion performance by coupled dissolution and membrane mass transfer measurements. Molecular pharmaceutics, 16(1), 448-461.
Hisada, N., Takano, R., Takata, N., Shiraki, K., Ueto, T., Tanida, S., ... & Yamashita, S. (2016). Characterizing the dissolution profiles of supersaturable salts, cocrystals, and solvates to enhance in vivo oral absorption. European Journal of Pharmaceutics and Biopharmaceutics, 103, 192-199.
Ho, H., & Lee, J. (2011). PEG/PLA core/shell particles from coaxial electrohydrodynamic spray drying. Macromolecular Research, 19(8), 815-821.
Holm, R. (2019). Bridging the gaps between academic research and industrial product developments of lipid-based formulations. Advanced drug delivery reviews, 142, 118-127.
Hörmann, T. R., Jäger, N., Funke, A., Mürb, R. K., Khinast, J. G., & Paudel, A. (2018). Formulation performance and processability window for manufacturing a dual-polymer amorphous solid dispersion via hot-melt extrusion and strand pelletization. International journal of pharmaceutics, 553(1-2), 408-421.
Huang, Y., Zhang, Q., Wang, J. R., Lin, K. L., & Mei, X. (2017). Amino acids as co-amorphous excipients for tackling the poor aqueous solubility of valsartan. Pharmaceutical development and technology, 22(1), 69-76.
Isaac, J., Ganguly, S., & Ghosh, A. (2016). Co-milling of telmisartan with poly (vinyl alcohol)–an alkalinizer free green approach to ensure its bioavailability. European Journal of Pharmaceutics and Biopharmaceutics, 101, 43-52.
Jacobsen, A. C., Elvang, P. A., Bauer-Brandl, A., & Brandl, M. (2019). A dynamic in vitro permeation study on solid mono-and diacyl-phospholipid dispersions of celecoxib. European Journal of Pharmaceutical Sciences, 127, 199-207.
Jing, B., Wang, Z., Yang, R., Zheng, X., Zhao, J., Tang, S., & He, Z. (2016). Enhanced oral bioavailability of felodipine by novel solid self-microemulsifying tablets. Drug development and industrial pharmacy, 42(3), 506-512.
Kajdič, S., Vrečer, F., & Kocbek, P. (2018). Preparation of poloxamer-based nanofibers for enhanced dissolution of carvedilol. European Journal of Pharmaceutical Sciences, 117, 331-340.
Karemore, M. N., & Avari, J. G. (2019). Formulation, optimization, and in vivo evaluation of gastroretentive drug delivery system of nifedipine for the treatment of preeclampsia. AAPS PharmSciTech, 20(5), 1-16.
Keemink, J., Mårtensson, E., & Bergström, C. A. (2019). Lipolysis-permeation setup for simultaneous study of digestion and absorption in vitro. Molecular pharmaceutics, 16(3), 921-930.
Kenawy, E. R., Bowlin, G. L., Mansfield, K., Layman, J., Simpson, D. G., Sanders, E. H., & Wnek, G. E. (2002). Release of tetracycline hydrochloride from electrospun poly (ethylene-co-vinylacetate), poly (lactic acid), and a blend. Journal of controlled release, 81(1-2), 57-64.
Kivikero, N., Murtomaa, M., Ingelbeen, B., Antikainen, O., Räsänen, E., Mannermaa, J. P., & Juppo, A. M. (2009). Microscale granulation in a fluid bed powder processor using electrostatic atomisation. European Journal of Pharmaceutics and Biopharmaceutics, 71(1), 130-137.
Kumar, S. (2018). Pharmaceutical cocrystals: an overview. Indian Journal of Pharmaceutical Sciences, 79(6), 858-871.
Lahamage, S. R., Darekar, A. B., & Saudagar, R. B. (2016). Pharmaceutical Co-Crystallization. Asian Journal of Research in Pharmaceutical Science, 6(1), 51-58.
Leuner, C., & Dressman, J. (2000). Improving drug solubility for oral delivery using solid dispersions. European journal of Pharmaceutics and Biopharmaceutics, 50(1), 47-60.
Li, H., Li, H., Wei, C., Ke, J., Li, J., Xu, L., ... & Yang, M. (2018). Biomimetic synthesis and evaluation of histidine-derivative templated chiral mesoporous silica for improved oral delivery of the poorly water-soluble drug, nimodipine. European Journal of Pharmaceutical Sciences, 117, 321-330.
Li, J., Fu, Q., Liu, X., Li, M., & Wang, Y. (2016). Formulation of nimodipine nanocrystals for oral administration. Archives of pharmacal research, 39(2), 202-212.
Li, J., Li, L. B., Nessah, N., Huang, Y., Hidalgo, C., Owen, A., & Hidalgo, I. J. (2019). Simultaneous analysis of dissolution and permeation profiles of nanosized and microsized formulations of indomethacin using the in vitro dissolution absorption system 2. Journal of pharmaceutical sciences, 108(7), 2334-2340.
Li, J., Pan, H., Ye, Q., Shi, C., Zhang, X., & Pan, W. (2020). Carvedilol-loaded polyvinylpyrrolidone electrospun nanofiber film for sublingual delivery. Journal of Drug Delivery Science and Technology, 58, 101726.
Li, T., Geng, T., Md, A., Banerjee, P., & Wang, B. (2019). Novel scheme for rapid synthesis of hollow mesoporous silica nanoparticles (HMSNs) and their application as an efficient delivery carrier for oral bioavailability improvement of poorly water-soluble BCS type II drugs. Colloids and Surfaces B: Biointerfaces, 176, 185-193.
Li, Z., Zhang, W., Gao, Y., Xiang, R., Liu, Y., Hu, M., ... & Sun, J. (2017). Development of self-nanoemulsifying drug delivery system for oral bioavailability enhancement of valsartan in beagle dogs. Drug delivery and translational research, 7(1), 100-110.
Liapis, A. I., & Bruttini, R. (2020). Freeze drying. In Handbook of industrial drying (pp. 309-343). CRC press.
Lodagekar, A., Chavan, R. B., Mannava, M. C., Yadav, B., Chella, N., Nangia, A. K., & Shastri, N. R. (2019). Co amorphous valsartan nifedipine system: Preparation, characterization, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences, 139, 105048.
Luo, D., Kim, J. H., Park, C., Oh, E., Park, J. B., Cui, J. H., ... & Lee, B. J. (2017). Design of fixed dose combination and physicochemical characterization of enteric-coated bilayer tablet with circadian rhythmic variations containing telmisartan and pravastatin sodium. International journal of pharmaceutics, 523(1), 343-356.
M Shaikh, S., & M Avachat, A. (2011). Enhancement of solubility and permeability of candesartan cilexetil by using different pharmaceutical interventions. Current drug delivery, 8(4), 346-353.
Ma, K., Rozet, S., Tamada, Y., Yao, J., & Ni, Q. Q. (2019). Multi-layer nanofibrous tubes with dual drug-release profiles for vascular graft engineering. Journal of Drug Delivery Science and Technology, 53, 100900.
Medarević, D., Cvijić, S., Dobričić, V., Mitrić, M., Djuriš, J., & Ibrić, S. (2018). Assessing the potential of solid dispersions to improve dissolution rate and bioavailability of valsartan: In vitro-in silico approach. European Journal of Pharmaceutical Sciences, 124, 188-198.
Meng, J., Li, S., Yao, Q., Zhang, L., Weng, Y., Cai, C., ... & Tang, X. (2014). In vitro/in vivo evaluation of felodipine micropowders prepared by the wet-milling process combined with different solidification methods. Drug development and industrial pharmacy, 40(7), 929-936.
Meruva, S., Thool, P., Karki, S., Bowen, W., Ghosh, I., & Kumar, S. (2019). Downstream processing of irbesartan nanocrystalline suspension and mini-tablet development–Part II. International journal of pharmaceutics, 568, 118509.
Meruva, S., Thool, P., Shah, S., Karki, S., Bowen, W., Ghosh, I., & Kumar, S. (2019). Formulation and performance of Irbesartan nanocrystalline suspension and granulated or bead-layered dried powders–Part I. International journal of pharmaceutics, 568, 118189.
Mishra, J., Bohr, A., Rades, T., Grohganz, H., & Löbmann, K. (2019). Whey proteins as stabilizers in amorphous solid dispersions. European Journal of Pharmaceutical Sciences, 128, 144-151.
Moinuddin, S. M., Ruan, S., Huang, Y., Gao, Q., Shi, Q., Cai, B., & Cai, T. (2017). Facile formation of co-amorphous atenolol and hydrochlorothiazide mixtures via cryogenic-milling: enhanced physical stability, dissolution and pharmacokinetic profile. International journal of pharmaceutics, 532(1), 393-400.
Mu, H., Holm, R., & Müllertz, A. (2013). Lipid-based formulations for oral administration of poorly water-soluble drugs. International journal of pharmaceutics, 453(1), 215-224.
Mura, P., Valleri, M., Fabianelli, E., Maestrelli, F., & Cirri, M. (2019). Characterization and evaluation of different mesoporous silica kinds as carriers for the development of effective oral dosage forms of glibenclamide. International journal of pharmaceutics, 563, 43-52.
Narayana, L., Chella, N., Kumar, D., & Shastri, N. R. (2015). Design of a novel type IV lipid-based delivery system for improved delivery of drugs with low partition coefficient. Journal of liposome research, 25(4), 325-333.
Nguyen, D. N., Clasen, C., & Van den Mooter, G. (2016). Pharmaceutical applications of electrospraying. Journal of pharmaceutical sciences, 105(9), 2601-2620.
Palazi, E., Karavas, E., Barmpalexis, P., Kostoglou, M., Nanaki, S., Christodoulou, E., & Bikiaris, D. N. (2018). Melt extrusion process for adjusting drug release of poorly water soluble drug felodipine using different polymer matrices. European Journal of Pharmaceutical Sciences, 114, 332-345.
Paluch, K. J., Tajber, L., McCabe, T., O’Brien, J. E., Corrigan, O. I., & Healy, A. M. (2010). Preparation and solid state characterisation of chlorothiazide sodium intermolecular self-assembly suprastructure. European journal of pharmaceutical sciences, 41(5), 603-611.
Paluch, K. J., Tajber, L., McCabe, T., O’Brien, J. E., Corrigan, O. I., & Healy, A. M. (2011). Preparation and characterisation of novel chlorothiazide potassium solid-state salt forms: Intermolecular self assembly suprastructures. European Journal of Pharmaceutical Sciences, 42(3), 220-229.
Pandya, P. A., Shah, P. A., & Shrivastav, P. S. (2020). Facile separation of four co-formulated ternary antihypertensive drug combinations with a customized elution protocol using supercritical fluid chromatography. Microchemical Journal, 159, 105594.
Pandya, R. B., Mehta, T. A., & Gohel, M. C. (2015). Solid dispersion adsorbate-a novel technique for dissolution enhancement of febuxostat. International Journal of Pharmaceutical Sciences and Research, 6(10), 4236.
Pardeike, J., Strohmeier, D. M., Schrödl, N., Voura, C., Gruber, M., Khinast, J. G., & Zimmer, A. (2011). Nanosuspensions as advanced printing ink for accurate dosing of poorly soluble drugs in personalized medicines. International journal of pharmaceutics, 420(1), 93-100.
Paudel, A., Worku, Z. A., Meeus, J., Guns, S., & Van den Mooter, G. (2013). Manufacturing of solid dispersions of poorly water soluble drugs by spray drying: formulation and process considerations. International journal of pharmaceutics, 453(1), 253-284.
Porwal, A., Dwivedi, H., & Pathak, K. (2017). Decades of research in drug targeting using gastroretentive drug delivery systems for antihypertensive therapy. Brazilian Journal of Pharmaceutical Sciences, 53.
Poudel, S., & Kim, D. W. (2021). Developing pH-Modulated Spray Dried Amorphous Solid Dispersion of Candesartan Cilexetil with Enhanced In Vitro and In Vivo Performance. Pharmaceutics, 13(4), 497.
Pouton, C. W. (2006). Formulation of poorly water-soluble drugs for oral administration: physicochemical and physiological issues and the lipid formulation classification system. European journal of pharmaceutical sciences, 29(3-4), 278-287.
Prajapati, P. B., Patel, A., & Shah, S. A. (2021). DoE-Based Analytical-FMCEA for Enhanced AQbD Approach to MEER-RP-HPLC Method for Synchronous Estimation of Fifteen Antihypertensive Pharmaceutical Dosage Forms. Journal of AOAC International.
Pui, Y., Chen, Y., Chen, H., Wang, S., Liu, C., Tonnis, W., ... & Qian, F. (2018). Maintaining supersaturation of nimodipine by PVP with or without the presence of sodium lauryl sulfate and sodium taurocholate. Molecular pharmaceutics, 15(7), 2754-2763.
Rabinow, B. E. (2004). Nanosuspensions in drug delivery. Nature reviews Drug discovery, 3(9), 785-796.
Ross, S. A., Lamprou, D. A., & Douroumis, D. (2016). Engineering and manufacturing of pharmaceutical co-crystals: a review of solvent-free manufacturing technologies. Chemical Communications, 52(57), 8772-8786.
Shi, X., Xu, T., Huang, W., Fan, B., & Sheng, X. (2019). Stability and bioavailability enhancement of telmisartan ternary solid dispersions: the synergistic effect of polymers and drug-polymer (s) interactions. AAPS PharmSciTech, 20(4), 1-13.
Shitole, M. M., Dugam, S. S., Desai, N. D., Tade, R. S., & Nangare, S. N. (2020). Pharmaceutical applications of electrospun nanofibers: a state-of-the-art review. Asian Journal of Pharmacy and Technology, 10(3), 187-201.
Singh, A., & Van den Mooter, G. (2016). Spray drying formulation of amorphous solid dispersions. Advanced drug delivery reviews, 100, 27-50.
Singh, A., Worku, Z. A., & Van den Mooter, G. (2011). Oral formulation strategies to improve solubility of poorly water-soluble drugs. Expert opinion on drug delivery, 8(10), 1361-1378.
Singh, B., Singh, R., Bandyopadhyay, S., Kapil, R., & Garg, B. (2013). Optimized nanoemulsifying systems with enhanced bioavailability of carvedilol. Colloids and Surfaces B: Biointerfaces, 101, 465-474.
Smeets, A., Re, I. L., Clasen, C., & Van den Mooter, G. (2020). Fixed dose combinations for cardiovascular treatment via coaxial electrospraying: Coated amorphous solid dispersion particles. International journal of pharmaceutics, 577, 118949.
Smirnova, I., Suttiruengwong, S., Seiler, M., & Arlt, W. (2005). Dissolution rate enhancement by adsorption of poorly soluble drugs on hydrophilic silica aerogels. Pharmaceutical development and technology, 9(4), 443-452.
Sodeifian, G., Ardestani, N. S., Razmimanesh, F., & Sajadian, S. A. (2020). Experimental and thermodynamic analyses of supercritical CO2-Solubility of minoxidil as an antihypertensive drug. Fluid Phase Equilibria, 522, 112745.
Son, H. Y., Chae, B. R., Choi, J. Y., Shin, D. J., Goo, Y. T., Lee, E. S., ... & Choi, Y. W. (2018). Optimization of self-microemulsifying drug delivery system for phospholipid complex of telmisartan using D-optimal mixture design. Plos one, 13(12), e0208339.
Sorrenti, M., Catenacci, L., Cruickshank, D. L., & Caira, M. R. (2013). Lisinopril dihydrate: Single-crystal X-ray structure and physicochemical characterization of derived solid forms. Journal of pharmaceutical sciences, 102(10), 3596-3603.
Šrámková, I. H., Carbonell-Rozas, L., Horstkotte, B., Háková, M., Erben, J., Chvojka, J., ... & Šatínský, D. (2019). Screening of extraction properties of nanofibers in a sequential injection analysis system using a 3D printed device. Talanta, 197, 517-521.
Srivastava, D., Fatima, Z., Kaur, C. D., Tulsankar, S. L., Nashik, S. S., & Rizvi, D. A. (2019). Pharmaceutical cocrystal: a novel approach to tailor the biopharmaceutical properties of a poorly water soluble drug. Recent patents on drug delivery & formulation, 13(1), 62-69.
Subramanian, N., Sharavanan, S. P., Chandrasekar, P., Balakumar, A., & Moulik, S. P. (2016). Lacidipine self-nanoemulsifying drug delivery system for the enhancement of oral bioavailability. Archives of pharmacal research, 39(4), 481-491.
Sun, M., Li, B., Li, Y., Liu, Y., Liu, Q., Jiang, H., ... & Sun, J. (2017). Experimental observations and dissipative particle dynamic simulations on microstructures of pH-sensitive polymer containing amorphous solid dispersions. International journal of pharmaceutics, 517(1-2), 185-195.
Tanhaei, A., Mohammadi, M., Hamishehkar, H., & Hamblin, M. R. (2020). Electrospraying as a novel method of particle engineering for drug delivery vehicles. Journal of Controlled Release.
Torres-Martínez, E. J., Cornejo Bravo, J. M., Serrano Medina, A., Pérez González, G. L., & Villarreal Gómez, L. J. (2018). A summary of electrospun nanofibers as drug delivery system: Drugs loaded and biopolymers used as matrices. Current drug delivery, 15(10), 1360-1374.
Tran, T. H., Park, C., Kang, T., Park, Y. J., Oh, E., & Lee, B. J. (2015). Micromeritic properties and instrumental analysis of physical mixtures and solid dispersions with adsorbent containing losartan: comparison of dissolution-differentiating factors. Powder Technology, 272, 269-275.
Vadlamudi, H. C., Yalavarthi, P. R., MV, B. R., & Rasheed, A. (2017). In vitro characterization studies of self-microemulsified bosentan systems. Drug development and industrial pharmacy, 43(6), 989-995.
Van den Mooter, G. (2012). The use of amorphous solid dispersions: A formulation strategy to overcome poor solubility and dissolution rate. Drug Discovery Today: Technologies, 9(2), e79-e85.
Van Hoogevest, P., Liu, X., & Fahr, A. (2011). Drug delivery strategies for poorly water-soluble drugs: the industrial perspective. Expert opinion on drug delivery, 8(11), 1481-1500.
Verma, R., & Kaushik, D. (2020). Design and optimization of candesartan loaded self-nanoemulsifying drug delivery system for improving its dissolution rate and pharmacodynamic potential. Drug delivery, 27(1), 756-771.
Vithani, K., Goyanes, A., Jannin, V., Basit, A. W., Gaisford, S., & Boyd, B. J. (2019). An overview of 3D printing technologies for soft materials and potential opportunities for lipid-based drug delivery systems. Pharmaceutical research, 36(1), 1-20.
Vithani, K., Hawley, A., Jannin, V., Pouton, C., & Boyd, B. J. (2018). Solubilisation behaviour of poorly water-soluble drugs during digestion of solid SMEDDS. European Journal of Pharmaceutics and Biopharmaceutics, 130, 236-246.
Vo, A. Q., Feng, X., Pimparade, M., Ye, X., Kim, D. W., Martin, S. T., & Repka, M. A. (2017). Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion. European Journal of Pharmaceutical Sciences, 102, 71-84.
Wang, K., Wen, H. F., Yu, D. G., Yang, Y., & Zhang, D. F. (2018). Electrosprayed hydrophilic nanocomposites coated with shellac for colon-specific delayed drug delivery. Materials & Design, 143, 248-255.
Warren, D. B., McPhee, E., Birru, W. A., Benameur, H., Chalmers, D. K., & Pouton, C. W. (2019). Location of solvated probe molecules within nonionic surfactant micelles using molecular dynamics. Journal of pharmaceutical sciences, 108(1), 205-213.
Water, J. J., Bohr, A., Boetker, J., Aho, J., Sandler, N., Nielsen, H. M., & Rantanen, J. (2015). Three-dimensional printing of drug-eluting implants: preparation of an antimicrobial polylactide feedstock material. Journal of pharmaceutical sciences, 104(3), 1099-1107.
Wei, A. F., Wang, J., Wang, X. Q., Wei, Q. F., & Hou, D. Y. (2011). Biodegradable electrospun fibers containing the compound antihypertensive drugs. In Advanced Materials Research (Vol. 332, pp. 1218-1222). Trans Tech Publications Ltd.
Wolkers, W. F., & Oldenhof, H. (Eds.). (2015). Cryopreservation and freeze-drying protocols. Humana Press.
Xi, L., Song, H., Wang, Y., Gao, H., & Fu, Q. (2018). Lacidipine amorphous solid dispersion based on hot melt extrusion: good miscibility, enhanced dissolution, and favorable stability. AAPS PharmSciTech, 19(7), 3076-3084.
Xiang, T. X., & Anderson, B. D. (2019). Effects of molecular interactions on miscibility and mobility of ibuprofen in amorphous solid dispersions with various polymers. Journal of pharmaceutical sciences, 108(1), 178-186.
Xiong, X., Zhang, M., Hou, Q., Tang, P., Suo, Z., Zhu, Y., & Li, H. (2019). Solid dispersions of telaprevir with improved solubility prepared by co-milling: formulation, physicochemical characterization, and cytotoxicity evaluation. Materials Science and Engineering: C, 105, 110012.
Yang, J., Wang, K., Yu, D. G., Yang, Y., Bligh, S. W. A., & Williams, G. R. (2020). Electrospun Janus nanofibers loaded with a drug and inorganic nanoparticles as an effective antibacterial wound dressing. Materials Science and Engineering: C, 111, 110805.
Yang, Y., Zhu, T., Liu, Z., Luo, M., Yu, D. G., & Bligh, S. A. (2019). The key role of straight fluid jet in predicting the drug dissolution from electrospun nanofibers. International journal of pharmaceutics, 569, 118634.
Yasser, M., Teaima, M., El-Nabarawi, M., & El-Monem, R. A. (2019). Cubosomal based oral tablet for controlled drug delivery of telmisartan: formulation, in-vitro evaluation and in-vivo comparative pharmacokinetic study in rabbits. Drug development and industrial pharmacy, 45(6), 981-994.
Yeom, D. W., Chae, B. R., Son, H. Y., Kim, J. H., Chae, J. S., Song, S. H., ... & Choi, Y. W. (2017). Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system. International journal of nanomedicine, 12, 3533.
Yin, X., Pan, H., & Liu, H. (2019). A Novel Micron-Size Particulate Formulation of Felodipine with Improved Release and Enhanced Oral Bioavailability Fabricated by Coaxial Electrospray. AAPS PharmSciTech, 20(7), 1-8.
Yu, D. G., Li, J. J., Williams, G. R., & Zhao, M. (2018). Electrospun amorphous solid dispersions of poorly water-soluble drugs: A review. Journal of Controlled Release, 292, 91-110.
Yu, D. G., Wang, M., Li, X., Liu, X., Zhu, L. M., & Annie Bligh, S. W. (2020). Multifluid electrospinning for the generation of complex nanostructures. Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 12(3), e1601.
Yu, L. X., Amidon, G. L., Polli, J. E., Zhao, H., Mehta, M. U., Conner, D. P., ... & Hussain, A. S. (2002). Biopharmaceutics classification system: the scientific basis for biowaiver extensions. Pharmaceutical research, 19(7), 921-925.
Zhao, J., Luo, L., Fu, Q., Guo, B., Li, Y., Geng, Y., ... & Zhang, T. (2016). Improved Oral Bioavailability of Lacidipine Using Nanosuspension Technology: Inferior in vitro Dissolution and Superior in vivo Drug Absorption versus Lacipil®. Current drug delivery, 13(5), 764-773.
Zhao, K., Yuan, Y., Wang, H., Li, P., Bao, Z., & Li, Y. (2016). Preparation and evaluation of valsartan by a novel semi-solid self-microemulsifying delivery system using Gelucire 44/14. Drug development and industrial pharmacy, 42(10), 1545-1552.
Zhong, L., Zhu, X., Luo, X., & Su, W. (2013). Dissolution properties and physical characterization of telmisartan–chitosan solid dispersions prepared by mechanochemical activation. AAPS PharmSciTech, 14(2), 541-550.
Zhou, M., Ao, J., Liu, S., Wu, C., Lai, A., Gao, H., & Zhang, G. (2017). A new polymorphic form of metoprolol succinate. Pharmaceutical development and technology, 22(1), 58-62.
Zhu, Q., Toth, S. J., Simpson, G. J., Hsu, H. Y., Taylor, L. S., & Harris, M. T. (2013). Crystallization and dissolution behavior of naproxen/polyethylene glycol solid dispersions. The journal of physical chemistry B, 117(5), 1494-1500.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
