Development and characterisation of methylphenidate hydrochloride loaded nanoparticles

Anju Singh; Ajay Kumar

doi:10.53730/ijhs.v6nS1.6724

Authors

Anju Singh Department of Biotechnology, Faculty of Engineering and Technology, Rama University, G.T. Road, Kanpur - 209217, India
Ajay Kumar
ajaymtech@gmail.com
Department of Biotechnology, Faculty of Engineering and Technology, Rama University, G.T. Road, Kanpur - 209217, India

Keywords:

Synthesis, Nanoparticles, Eudragit RL 100, Methylphenidate Hydrochloride

Abstract

Preparation of Methylphenidate Hydrochloride nanoparticles was the goal of this study, which aimed to minimise the dosage frequency. Polymeric nanoparticles are gaining in popularity due to their inertness, solubility in non-toxic solvents, and ability to be used to create sustained-release dosage forms, among other characteristics. Melphenidate hydrochloride, a diuretic, is used to treat congestive heart failure, edoema, and renal failure among other conditions. Polymeric nanoparticles are one of the most effective platforms for long-term release because of their high stability. To put it another way, because its half-life (2.4 hours for children and 2.1 for adults) is short, methylphenidate hydrochloride is only effective for an extremely short period of time. This study's major focus is on nanoparticles. Eudragit RL 100 can be used as a release retardant. Formulation of Methylphenidate Hydrochloride and Eudragit RL 100 nanoparticles in order to provide long-term activity and hence boost bioavailability. The steady release of Methylphenidate Hydrochloride from nanoparticles increases therapeutic efficacy by maintaining a constant drug plasma concentration. The new formulation of methylphenidate hydrochloride sustained release proved successful in alleviating the problems associated with the old one.

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