Solvent evaporation method of preparation of nanoparticle and in-vitro drug release study of Methylphenidate Hydrochloride
Keywords:
nanoparticles, methylphenidate hydrochloride, in vitro drug release studyAbstract
The purpose of this work was to develop Methylphenidate Hydrochloride nanoparticles, which would reduce dose frequency. Since they are non-toxic and may be utilised to construct long-acting dosage forms, polymeric nanoparticles have gained a lot of attention in recent years. Congestive heart failure, edoema, and renal failure are among the disorders for which the diuretic melphenidate hydrochloride is prescribed. Because of their exceptional stability, polymeric nanoparticles are an excellent substrate for long-term release. In other words, the half-life of methylphenidate hydrochloride (2.4 hours for children, and 2.1 hours for adults) is so short that it is only effective for a very short duration. Nanoparticles are the primary subject of this investigation. Using Eudragit RL 100 as a release retardant is possible. Therapeutic effectiveness is increased by maintaining a consistent plasma concentration of Methylphenidate Hydrochloride from nanoparticles. The new methylphenidate hydrochloride sustained release formulation proved to be a success in reducing the issues associated with the previous one.
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