Design, synthesis and biological activity of 4-amino-5-(Benzimidazole-1-yl) triazole
Keywords:
Benzimidazole, Anticancer, QSAR, Characterization, Pharmacologoical activityAbstract
Triazoles are an important class of nitrogen containing heterocycles, because many of them exhibit interesting biological activities, such as anti-inflammatory, antidepressant, antifungal, anticancer,anti-TB, analgesic and hypoglycemic. Sulfur-linked 1,2,4-triazoles represent an important group in lead compound discovery. Many bioactive sulfur-linked 1,2,4-triazole have been reported, such as antibacterial activity, antitumor activity, anti-HIV activity, anti-TMV (tobacco mosaic virus) activity, and so on. We report Synthesis and Biological activity of 4-amino-5-(Benzimidazole-1-yl) Triazole.
Downloads
References
J.A. Joule, G. F. Smith, Heterocyclic Chemistry, Van Nostrand Reinhold Co., 2nd Ed., London (1978).
T. L. Gilchrist, Heterocyclic Chemistry, Pitman London, (1985), p.189.
D. Sriram, P. Yogeeswari, K. Madhu, Bioorg. Med. Chem. Lett., (2005), 15, 4502.
X. Y. Yu, J. M. Hill, G. Yu, W. Wang, A. F. Kluge, P. Wendler, P. Gallant, Bioorg. Med. Chem. Lett., (1999), 9, 375.
B. Narayana, K. K. Vijaya Raj, B. Ashalatha, N. SuchethaKumari, Arch. Pharm., (2005), 338, 373.
M. S. Joseph, R. S. Totagi, L. D. Basanagoudar, Indian J. Chem., (2004), 43B, 964.
C. J. Dinsmore, D. C. Beshore, Tetrahedron, (2002), 58, 3297.
A. T. Balaban, D. C. Oniciu, A. R. Katritzky, Chem. Rev., (2004), 104, 2777.
A. F. Pozharskii, A. T. Soldatenkov, A. R. Katritzky, Heterocycles in Life and Society, John Wiley-VCH, New York, (1997), p. 301.
C. M. Coleman, J. M. D. MacElroy, J. F. Gallagher, D. F. J. O. Shea, J. Comb. Chem., (2002), 4, 87.
A. R. Kartritzky, Hand Book of Heterocyclic Chemistry, 1st Ed. Pergamon Press Oxford. (1985), 87.
O. R. Gautun, P. H. J. Carlsen. ActaChem Scand., (1992), 46, 469.
B. I. Buzykin, E. V. Mironova, V. N. Nabiullin, A. Gubaidullin, I. A. Litvinov, Russ. J. Gen. Chem., (2006), 76, 1471.
A. V. Dolzhenko, G. K. Tan, L. L. Koh, A. V. Dolzhenko, W. K. Chui, ActaCryst., (2009), E65, 126.
A. R. Katritzky, J.M. Lagowski, Adv. Heterocycli. Chem., (1963), 18, 27.
G. L. Almajan, S.F. Barbucenau, E. R. Almajan, C. Draghici, G. Saramet. Eur. J. Med. Chem., (2009), 44, 3083.
H. Bektas, N. Karaali, D. Sahin, A. Demirbas, S. A. Karaoglu, N. Demirbas, Molecules, (2010), 15, 2427.
S. Bahceci, H. Yuksek, Z. Ocak, C. M. Koksal, Ozdemir, ActaChimSlov., (2002), 49, 783.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
