Study of the effect of fluoxetine on liver enzymes in the blood serum of pregnant albino rats

Mustafa Naeem Abdulwhid Al-Zubaidi; Alaa Hussein Al-Safy

doi:10.53730/ijhs.v6nS3.7485

Authors

Mustafa Naeem Abdulwhid Al-Zubaidi
mustafa.n@s.uokerbala.edu.iq
Department of Biology, College of Education for Pure Sciences, University of Kerbala, Karbala, Iraq
Alaa Hussein Al-Safy Department of Biology, College of Education for Pure Sciences, University of Kerbala, Karbala, Iraq

Keywords:

fluoxetine, liver enzyme, pregnancy

Abstract

The current study examined the effect of fluoxetine on liver enzymes in pregnant female rats. 42 rats, including ten males, were used for inoculation only, while the number of females was 32 rats. Female rats were divided into two groups, the control group consisted of 8 rats. The fluoxetine-treated group of 24 females was divided into three groups. The first group included 8 pregnant female rats injected with fluoxetine at a concentration of 20 mg/kg of body weight from day 0 of gestation until day 7 or 18, and the second group also included 8 pregnant females injected with fluoxetine at a concentration of 40 mg/kg. of body weight from day day 0 of gestation until day 7 or 18, and the third group included 8 pregnant females injected with fluoxetine at a concentration of 60 mg/kg of body weight from day 0 of gestation until day 7 or 18, blood samples were collected on the 7 or 18 days From pregnancy from all animal groups to measure the following parameters: ALT, alkaline phosphatase, ALP, and aspartate aminotransferase (AST).

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