Study the possibility of the effect of fluoxetine on the process of implantation of the blastocyst in the uterus of pregnant albino rats?

Mustafa Naeem Abdulwhid Al-Zubaidi; Alaa Hussein Al-Safy

doi:10.53730/ijhs.v6nS3.7486

Authors

Mustafa Naeem Abdulwhid Al-Zubaidi
mustafa.n@s.uokerbala.edu.iq
Department of Biology, College of Education for Pure Sciences, University of Kerbala, Karbala, Iraq
Alaa Hussein Al-Safy Department of Biology, College of Education for Pure Sciences, University of Kerbala, Karbala, Iraq

Keywords:

blastocyst, fluoxetine, implantation, pregnant, albino rats

Abstract

The current study dealt with knowing the effect of fluoxetine on the process of implantation of the blastocyst in the uterus of pregnant rats, which occurs in the rat on the sixth day of pregnancy because the implantation of the blastocyst is a very critical period of pregnancy. 26 females and male rats were used. Female rats were divided into two groups, the control group, and included 4 rats injected with the physiological solution inside the peritoneal cavity from day zero of pregnancy. The treatment group of 12 females was divided into two groups, the first included 4 females who were injected from day 0 of pregnancy with fluoxetine 20 mg/kg of body weight, and the second also included 4 females who were injected from day 0 of pregnancy with 40 mg/kg of body weight, and the third also included 4 females. From day 0 of pregnancy, she was injected with fluoxetine 60 mg/kg body weight. The histological technique was applied to uterine sections on the 7th day of pregnancy, and samples were stained with hematoxylin-eosin stain.

Downloads

Download data is not yet available.

References

Gao, S.-Y., Wu, Q.-J., Zhang, T.-N., Shen, Z.-Q., Liu, C.-X., Xu, X., … Zhao, Y.-H. (2017). Fluoxetine and congenital malformations: a systematic review and meta-analysis of cohort studies. British Journal of Clinical Pharmacology, 83(10), 2134–2147.

Barakat, A., Hamdy, M. M., & Elbadr, M. M. (2018). Uses of fluoxetine in nociceptive pain management: A literature overview. European journal of pharmacology, 829, 12-25.‏

Cao, B., Zhu, J., Zuckerman, H., Rosenblat, J. D., Brietzke, E., Pan, Z., & McIntyre, R. S. (2019). Pharmacological interventions targeting anhedonia in patients with major depressive disorder: a systematic review. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 92, 109-117.‏

Raveendran, A. V., & Agarwal, A. (2021). Premature ejaculation-current concepts in the management: A narrative review. International Journal of Reproductive BioMedicine, 19(1), 5.‏

Crow, S. J. (2019). Pharmacologic treatment of eating disorders. Psychiatric Clinics, 42(2), 253-262.‏

Locher, C., Koechlin, H., Zion, S. R., Werner, C., Pine, D. S., Kirsch, I., ... & Kossowsky, J. (2017). Efficacy and safety of selective serotonin reuptake inhibitors, serotonin-norepinephrine reuptake inhibitors, and placebo for common psychiatric disorders among children and adolescents: a systematic review and meta-analysis. JAMA psychiatry, 74(10), 1011-1020.‏

Graham, R. M., Jiang, L., McCorkle, G., Bellando, B. J., Sorensen, S. T., Glasier, C. M., ... & Ou, X. (2020). Maternal anxiety and depression during late pregnancy and newborn brain white matter development. American Journal of Neuroradiology, 41(10), 1908-1915.

Walsh, K., McCormack, C. A., Webster, R., Pinto, A., Lee, S., Feng, T., ... & Monk, C. (2019). Maternal prenatal stress phenotypes associate with fetal neurodevelopment and birth outcomes. Proceedings of the National Academy of Sciences, 116(48), 23996-24005.

Achache, H. and Revel, A.( 2006). Endometrial receptivity markers, the journey to successful embryo implantation. Hum Reprod Update;12:731–746.

Mori, M.; Kitazume, M.; Ose, R.; Kurokawa, J.; Koga, K.; Osuga, Y.; Arai, S. and Miyazaki, T.(2011). Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. J. Clin. Invest. ;121:318–327.

Ochoa-Bernal, M. A., & Fazleabas, A. T. (2020). Physiologic events of embryo implantation and decidualization in human and non-human primates. International journal of molecular sciences, 21(6), 1973.‏

Chambers, C. D., Johnson, K. A., Dick, L. M., Felix, R. J., & Jones, K. L. (1996). Birth outcomes in pregnant women taking fluoxetine. New England Journal of Medicine, 335(14), 1010-1015.‏

Riggin, L., Frankel, Z., Moretti, M., Pupco, A., & Koren, G. (2013). MOTHERISK ROUNDS: The Fetal Safety of Fluoxetine: A Systematic Review and Meta-Analysis. Journal of Obstetrics and Gynaecology Canada, 35(4), 362-369.‏

Cha, J. ; Sun, X and Dey, S.K. (2012) Mechanisms of implantation: strategies for successful pregnancy . Nature. Med. 18, 1754–1767.

Herington, J. L., & Bany, B. M. (2009). Do molecular signals from the conceptus influence endometrium decidualization in rodents?. Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, 312(8), 797-816.‏

Das, S.K.(2010). Regional Development of Uterine Decidualization: Molecular Signaling by Hoxa-10. Mol. Reprod. Dev. ; 77(5): 387–396.

Sroga, J.M.; Ma, X.; and Das, S. K. (2012). Developmental regulation of decidual cell polyploidy at the site of implantation. Front Biosci (Schol Ed).; 4: 1475–1486.

Wooding, F. B. P. and Burton, G .(2008).Comparative Placentation: Structures, Functions and Evolution. Springer .47-81.

AL-Safy, A. H. and Yasear, A. Y. (2018). Does dexamethasone interfere with process of blastocyst implantation in the pregnant rat uterus?. journal of kerbala university, 14(1), 271-278.‏

Kelly, R.W.; King, A.E. and Critchley, H.O. (2001). Cytokine control in human endometrium. Rep. 121:3-19.

Afshar, Y.; Stanculescu, A.; Miele, L. and Fazleabas, A. T. (2007). The role of chorionic gonadotropin and Notch1 in implantation. J. Assist. Reprod. Genet. 24: 296-302.

Michael, A. E. and Papageorghiou, A. T. (2008).Potential significance of physiological and pharmacological glucocorticoids in early pregnancy . Human Reproduction Update, 14(5) : 497–517.

AL-Safy, A. H., and Yasear, A. Y.(2018). EFFECT OF DEXAMETHASONE ON THE DISTRIBUTION OF COLLAGEN FIBERS IN THE PREGNANT RAT’S UTERUS: A HISTOLOGICAL STUDY. Biochem. Cell. Arch. 18( 1): 605-610.