The spectrum of magnetic resonance imaging (MRI) patterns in hospitalised hypoxic ischemic encephalopathy babies in a tertiary care hospital of Odisha

https://doi.org/10.53730/ijhs.v6nS2.7872

Authors

  • Rajesh Kumar Rout Senior Resident, Department of Pediatrics, MKCG Medical College Berhampur. Odisha, India
  • B Maheswar Rao Associate Professor, Department of Pediatrics, Bhima Bhoi Medical College, Balangir, Odisha, India
  • Saroj Shekhar Rath Assistant Professor, Department of Pediatrics, MKCG Medical College Berhampur. Odisha, India
  • Swapna Mahapatra Assistant Professor, Department of Pharmacology, MKCG Medical College Berhampur. Odisha, India
  • Shantisena Mishra Professor and HOD, Department of Pediatrics, Bhima Bhoi Medical College, Balangir, Odisha, India

Keywords:

HIE, MRI, perinatal asphyxia

Abstract

Background: Hypoxic ischemic encephalopathy (HIE) refers to the CNS dysfunction associated with Perinatal Asphyxia (PA) which is an important causes of permanent damage to CNS tissue. MRI imaging methods attributes to better understanding of pathological events and disease progression that may provide decision regarding intervention.  MRI has a higher sensitivity and is extremely valuable in assessing the extent of hypoxic-ischemic brain damage during the early postnatal period and later infancy. It is also more specific which clearly differentiates fluid filled cavities, oedema, gliosis and hemorrhage. On this background this study was undertaken to evaluate the MRI changes of all grades of HIE patients. They were also followed up at different time intervals for upto 1 year to correlate the MRI changes and neurodevelopmental outcome. Objectives: To find out different MRI findings in hypoxic ischemic encephalopathy babies. Assesment of severity of HIE from MR imaging and correlate these findings with clinical & neurodevelopmental outcome. Methods: All hemodynamically stable HIE babies irrespective of their severity were subjected to MRI between day 7 and day 21 of life and their findings were interpreted. 

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References

WHO perinatal mortality: a listing of available information. FRH/ MSM.96.7 Geneva, WHO, 1996.

Ramesh Agarwal, Ashok Deorari, Vinod Paul, M J Sankar, Anu Sachdeva. AIIMS Protocols in Neonatology 2019; vol-1:p-56.

Liu L, Johnson HL, Cousens S et al. Global, regional, and national causes of child mortality: an updated systemic analysis for 2010 with time trends since 2000. Lancet 2012; 379:2151-61.

Lawn JE, Blencowe H, Oza S et al; Lancet Every Newborn study group. Every newborn: progress,priorities, and potential beyond survival. Lancet 2014;384:189-205.

Report of the National neonatal Perinatal database (NNPD) National Neonatal Forum, India 2003.

Hill A, Volpe JJ. Hypoxic ischemic cerebral injury in the newborn. In: Swaiman KF edn. Pediatric Neurology- Principles and Practice. 2nd edn., Missouri: Mosby Publishers, 1994;489-508.

Deirdre M. Murray, Geraldine B. Boylan, Cornelius A. Ryan et al. Early EEG findings in hypoxic ischemic encephalopathy predict outcomes at 2 years. Pediatrics 2009124(3) 459-467.

Castello AM de L, Hamilton et al. prediction of neurodevelopmental impairment at 4 years from brain USG appearance of very preterm infants. Dev. Med. Child. Neurol-1988;30:711-722.

Fawer CL, Diebold P et al. Periventricular leucomalacia and neurodevelopmental outcome in preterm infants. Archives of Disease in childhood1987 62(1), 30-36.

Siegal M, Shackelford G et al. Hypoxic ischemic encephalopathy in term infants diagnosis and prognosis evaluation by USG. Radiology 1984;152:395-9.

De Vries LS, Dubowitz L MS et al. Pediatrics value of cranial USG a reappraisal Lancet 1985;11:137-40.

Brenner DJ et al. Estimating cause risk from Pediatric CT: going from the qualitative to quantitative. Pediatr Radiol, 2002 Apr 36(4):228-1.

Barkovich AJ et al. The encephalopathic neonate; choosing the proper imaging technique. AJNR American journal of Neuroradiol 1997 Nov-Dec; 18(10):1816-20

Barkovich AJ. MR and CT evaluation of profound neonatal and infantile asphyxia. Am the Neuroradiol 1992;13:959-72.

Keeney S, Adcock EW et al. prospective observation of 100 high-risk neonates by high field MRI of the central nervous system. Pediatircs 1991;87:431-8.

Barkovich AJ et al. Normal maturation of neonatal and infant brain: MR imaging at 1.5TI. Radiology 1988;166:173-80.

Stinlin M et al MRI following sever perinatal asphyxia: Preliminary experience. Pediatr Neuro 1991;7:164-70.

Schouman-Claeys E et al. Periventricular leukomalacia: Correlation between MR imaging and autopsy finding during the first 2 month of life. Radiology 1993;189: 59-64.

Northington FJ, Ferriero DM, Flock DL, Martin LJ. Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J Neurosci Mar 15;2001 21(6):1931–1938. [PubMed:11245678]

Nair MKC, George B, Philip E, MA Lekshmi MA, Haran JC, Sathy N. Trivandrum developmental screening chart. Indian pediatr. 1991;28:869-7.

Alderliesten T, de Vries L S, Benders M J N L et al. MR imaging and outcome of Term Neonates with perinatal asphyxia. Radiology;volume 261:number 1-oct 2011.

Sanjay Khaladkar, Aditi M, Gujarathi, Vigyat Kamal, Rajesh Kuber.MRI Brain in Perinatal Hypoxia – A Case Series.July 2016.IOSR Journal of Dental and Medical Sciences 15(07):100-114.

Cheong J L Y, Coleman L et al. Prognostic utility of Magnetic Resonance Imaging in Neonatal Hypoxic – ischemic Encephalopathy. Arch Pediatr Adolesc Med. 2012;166(7): 634-640.

Tivedi S B, Vesoulis Z A, Rao R et al. A validated clinical MRI injury scoring system in neonatal hypoxic –ischemic encephalopathy. Pediatr radiol. 2017 oct; 47(11):1491-1499.

Agut T, Leon M, Rebollo M et al. Early identification of brain injury in infants with hypoxic ischemic encephaliopathy at high risk for sever impairments.BMC pediatrics 2014,14: 177.

Miller S P, Ramaswamy V, Michelson D et al.Patterns of brain injury in term neonatal encephalopathy. J Pediatr 2005;146: 453-60.

Miller S P, Weiss J, Barnwell A et al. Seizure associated with brain injury in term newborns with perinatal asphyxia. Neurology 58(4), 542-548, 2002.

Published

25-05-2022

How to Cite

Rout, R. K., Rao, B. M., Rath, S. S., Mahapatra, S., & Mishra, S. (2022). The spectrum of magnetic resonance imaging (MRI) patterns in hospitalised hypoxic ischemic encephalopathy babies in a tertiary care hospital of Odisha. International Journal of Health Sciences, 6(S2), 10711–10718. https://doi.org/10.53730/ijhs.v6nS2.7872

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