Nootropic activity of ethanolic extract of Triticum aestivum in acute and chronic stress induced Wistar albino rats
Keywords:
stress, triticum aestivum, transfer latency, ulcer indexAbstract
Objectives- The present study was designed to evaluate the nootropic activity of ethanolic extract of Triticum aestivum (TAE) on stressed wistar albino rats. Materials and methods- Effect of TAE was studied on acute restraint stress and chronic unpredictable stress induced rats. Chronic unpredictable stress was given for 10days. The reference standard drug (Piracetam-200mg/kg) and the test drug, TAE at doses of 150mg/kg and 200mg/kg b.w. were given to rats for 14 days. Learning and memory was assessed by using Elevated plus maze test. Animals sacrificed at the end of this experiment, the body weight adrenal and spleen weight, ulcer index as well as various biochemical parameters like malondialdehyde (MDA) and superoxide dismutase (SOD) were assessed. Results- Both acute as well as chronic stress induced a significant prolongation of learning time, whereas only with chronic unpredictable stress the memory or retention time was longer than that of the non-stressed control rats. Piracetam and TAE treated rats showed a significant reduction in acquisition and retention time in stress induced rats. Also, the stress induced ulcer scores were significantly reduced. The effects were comparable to normal control rats.
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References
McEwen.The neurobiology of stress: from serendipity to clinical relevance. Brain Research. 2000: 172-89.
M.Krishnamoorthy. Antioxidant activities of bark extract from mangroves, Brugiera cylindrica Blume and Ceriops decandra Perr. Indian journal of pharmacology. 2011(43):557.
Ketan Shah, Devang Sheth, Pravin Tirgar.Anti ulcer activity of Triticum aestivum on ethanol induced mucosal damage (cyto-protective activity) in wistar rats. Pharmacologyonline 2011; (2):929-35.
Mates MJ, Jimenez S, Fransisca M. Role of reactive oxygen species in apoptosis: implication for cancer therapy. The International Journal of Biochemistry and Cell Biology 2000; 32(2):157-70.
Nenonen MT, Helve TA, Rauma AL, Hanninen OO. Uncooked,Lactobacilli-rich, Vegan Food and Rheumatoid Arthritis. British Journal of Rheumatology 1998 (37):274-81
I.Prusty. Effect of triticum aestivum grass powder on different models of type-2 diabetes mellitus on wistar albino rats.2011.
Jung-Hee Jang, Chang-Yul Kim, Sun Ha Lim. Neuroprotective effects of Triticum aestivum L. against β-Amyloid-induced cell death and memory impairments. Phytotherapy Research. 2010 (24):74-86.
P.J. Mitchell, P.H. Redfern. Animal Models of Depressive Illness.Current Pharmaceutical Design 2005;11:171-203:
Leslie Matuszewich ,Jared J.Karney ,Samantha R.Carter ,Steven Johanna L.O’Brien & Ross D. Friedman.The delyed effect of chronic unpredictable stress on anxiety measures.Physiol Behav.March 2007;(4):674-81.
N Venkata Rao, Basavaraj Pujar. Nootropic activity of tuber extract of Pueraria tuberosa (roxb) . Indian Journal of Experimental Biology. 2008; 46: 591-98.
S.K. Kulkarni .Handbook of experimental pharmacology 3rd ed.1996.p-55.
Imrana Tabassum, Zeba N Siddiqui, Shamim J Rizvi.Effect of Ocimum sanctum and Camellia on stress induced anxiety and depression in male albino Rattus norvegicus Indian journal of pharmacology 2010 ;42(5) :283-88.
P. Mahendra, S. Bisht. Antianxiety activity of Coriandrum sativum assessed using different experimental anxiety models. Indian journal of pharmacology 2011(43):574-77.
S.K Bhattacharyaa, A.V Muruganandam .Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress Pharmacology Biochemistry and Behavior. 2003 (75): 547–55.
R.A Patil, S. C. Jagdale. Antihyperglycaemic, antistress and nootropic activity of root of Rubia cordifolia .Indian journal of experimental biology 2006; 44: 987-92.
Vandana S. Nade, Laxman A.Adaptogenic effect of Morus alba on chronic footshock-induced stress in rats. Indian journal of pharmacology.2009 (41): 246-51.
Moynihan JA, Alder R.Psychoneuroimmunology: Animal models of Disease.Psychosomatic Medicine,American Psychosomatic Society.1996; 58: 546-58
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