Comparison of leptin levels in thin and obese type 2 diabetes mellitus patients with non diabetics in relation to basal metabolic rate

J Sowndharya; R Menaha; B Poonguzhali; G Jeyachandran; K Suganya

doi:10.53730/ijhs.v6nS2.8042

Authors

Sowndharya. J
sowndaryaj27@gmail.com
Senior Assistant Professor, Department of Biochemistry, Government Karur Medical College & Hospital, Karu, Tamilnadu, India
Menaha. R Tutor, Department of Biochemistry, Government Karur Medical College & Hospital, Karur, Tamilnadu, India
Poonguzhali. B Senior Assistant Professor, Department of Biochemistry, Government Karur Medical College & Hospital, Karur, Tamilnadu, India
Jeyachandran. G Professor & Head, Department of Biochemistry, PSG Institute of medical Sciences & Research, Coimbatore, Tamilnadu, India
Suganya. K Assistant professor, Department of Physiology, SRMC & RI, SRIHER, Porur, Chennai, Tamilnadu, India

Keywords:

diabetes mellitus, patients, leptin, body mass index

Abstract

Background: Leptin is considered to have a role in regulation of body weight and energy metabolism. Increased level of serum Leptin is considered as a component of metabolic syndrome. Also resistance to Leptin in β-cells results in hyperinsulinemia due to the absence of inhibitory effect of Leptin on insulin secretion. This may lead to the exhaustion of β-cells in the pancreas leading to the progression of Type 2 DM. Our study was put forward to identify the Leptin levels among diabetic and non-diabetic individuals and its correlation with body mass index. Materials & Methods: In each group 40 subjects were recruited. Their samples were collected and Leptin was assayed using ELISA kit. Other parameters like Fasting and Post Prandial Glucose, HbA1c, Cholesterol, Triglycerides, High Density Lipoprotein and Low Density Lipoprotein were also analyzed as a supportive measure. Result & Conclusion: There was no significant difference in Leptin levels in both obese diabetic and obese control groups. Leptin level was confined to the lower side in thin groups. There is a significant positive correlation between Leptin and body mass index. Female subjects have got increased Leptin value than male subjects.

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