Synthesis and spectroscopic study of new ligand 3-(acetylthioureido)propanoic acid with their metal complexes
Keywords:
beta alanine, acetyl isothiocyanate, metal complexesAbstract
A new ligand 3-(3-acetylthioureido)propanoic acid (ATA) was prepared through the reaction of acetyl chloride, ammonium thiocyanate and b- alanine. For this study the following methods were used: FT-IR, 1H-NMR 13C-NMR spectra and the Elemental analysis. complexesis of M+2=Mn,Cu,Ni,Co,Zn,Cd and Hg derived from3-(3-acetylthioureido) propanoic acid have been synthesized and characterized by elemental analyses, molar conductance, magnetic suscpility, FT-IR, UV Vis spectra, The results have shown complexation with b-alanine derivative with metal ion in a 1:2 ratio. The spectral characterization confirms the formation of ligand and complexes. The evidences from the above results suggest the ligand to be abi dentate ion.
Downloads
References
Anusevičius, K., Jonuškienė, I., & Mickevičius, V. (2013). Synthesis and antimicrobial activity of N-(4-chlorophenyl)-β-alanine derivatives with an azole moiety. Monatshefte für Chemie-Chemical Monthly, 144(12), 1883-1891.
Mickevicˇius V, Mickevicˇius M, Vaickelioniene R, Jakien _ e E _ (2008) Chem Technol 48:70
Kuffler, S.W., Edwards, C., J. Neurophysiol. 1958, 21, 589 – 610. Wilson, C. Y., Velayudham, S., Manickam, S., & 4-Deivanayagam, E. (2015). [Beta]-Tolyl Alanine Derived Schiff Base Complexes-Synthesis Characterization and Antimicrobial Assessment. Journal of Pharmaceutical Sciences and Research, 7(1), 25.
Zheng, C., Shi, R., Jin, X., Dong, L., & Li, H. (2015). β-Alanine Zn (II) and Cd (II) coordination complexes with diamondoid frameworks possessing second-order nonlinear optics properties. Inorganic Chemistry Communications, 58, 74-78.
Medvidović-Kosanović, M., Stanković, A., Drulak, M., & Sak-Bosnar, M. (2018). Potentiometric, electrochemical and UV/VIS investigation of a copper (II) complex with β-alanyl-L-histidine. Int. J. Electrochem. Sci, 13, 5323-5332.
SangeethaGowda, K.R., BhojyaNaik, H.S., Vinay Kumar, B., Sudhamani, C, N., Sudeep, H.V., Ravikumar Naik, T.R., Krinamurthy, G., Spectrochim. Acta Part A 2013, 105, 861 – 868.
Jonusˇkiene I, Kuusien _ e S, Mickevic _ ˇius V (2008) Chem Technol 49:53
Laila. H. Abdel-Rahman, Rafat M. El-Khatib, Lobna .A.E.Nassr, Ahmed M. Abu-Dief, J. Mol. Str. 2013, 1040, 9 – 18.
Kabbani, A.T., Ramadan, H., Hammuud, H.H. and Hanuom, A.M.G.2005. “Synthesis of some metal complexes of N-[(benzoyl amino)-thioxomethyl] amino acid (HL)”, J. of the uni. of chem. tech. and meta., 40 (4): 339-344.
Garey, F.A. 2005. “Organic chemistry”,6th Ed,the M.C. Graw-Hill companies, Inc.,New York
Silverstein, Bassler RMGC, Movrll TC (1981) "Spectroscopic Identification of organic compound", 4th Ed, Wiley, New York
Nakamoto K, K left J (1967) "Infrared spectra of some platinum (ΙΙ) glycine complexes "J. Inor. Nucl. Chem., 29: 2561-2567.
B.M sarhan and R.M Rumeza and M.A Ali,(2015),Ibn Al-Haitham Journal for pureand applicd science;vol(28),NO(1),pp;142-156.
Ghani, H. A., & Sarhan, B. M. SYNTHESIS AND SPECTROSCOPIC STUDY OF N-(METHYLCARBAMOTHIOYL) ACETAMIDE WITH THEIR METAL COMPLEXES.
Dyer RG (1965) "Application of absorption spectroscopy of organic compounds" prentice Hall. Inc. Engl. Wood Cliffs, N.J. London
Al-Hashimi, S. M., Sarhan, B.M. and Jarad, A.J. 2011. “Synthesis and characterization complexes of 2-thiotolyurea with metal salts”, J. of Edu.,6: 543-553.
Bushra K .Al-salami, Raghed A.Gata and Kahtan A.Asker, synthesis spectral, Thermal stability and Bacterial Activity of Schiff bases derived from selective amino acid and their complexes , Advances in Applied science Research , 2017,8(3);4-12
Taher, T. A., Mahdi, W. K., & Musa, F. H. (2017). Synthesis and Characterization of some Metal Complexes with (3Z, 5Z, 8Z)-2-azido-8-[azido (3Z, 5Z)-2-azido-2, 6bis (azidocarbonyl)-8, 9-dihydro-2H-1, 7-dioxa-3, 4, 5triazonine-9-yl] methyl]-9-[(1-azido-1-hydroxy) methyl]-2H1, 7-dioxa-3, 4, 5-triazonine –2, 6 –dica. Ibn AL-Haitham Journal For Pure and Applied Sciences, 30(3), 77-90.
Deepak,M., Road, F. and Gunter,H. 2004. “Highly efficient stero conserrativeamidation and deamidion of amino acid”, Org. Lett., (6): 3675-3678.
Álvarez-Miguel, L., Álvarez-Miguel, I., Martín-Álvarez, J. M., Álvarez, C. M., Rogez, G., García-Rodríguez, R., & Miguel, D. (2019). Copper complexes for the promotion of iminopyridine ligands derived from β-alanine and self-aldol additions: relaxivity and cytotoxic properties. Dalton Transactions, 48(47), 17544-17555.
El-ajaily M M and Maihub A A (2010) Synthesis and SpectroscopicCharacter ization of Mn (II)-Benzoin Complex. Int. J. Chem.Tech. Res. 2(3), 1579-1580.
Sarhan B M, Al-Karboly M A and Zaidan D H (2016) Synthesis andcharacterization of some new metals Complexes of [N-(4-Nitrobenzoyl AminoThioxomethyl] phenylalane. Baghdad Sci. J.13(1), 113-121.
Sarhan M. and B. Fyadh, (2017), synthesis and spectroscopic studies of some Divalcant metal Ion complexes of [3-(3(2-chloro acetyl thiourido)pyrazine-2-carboxylic acid)], Al-Qadisiyha Journal of pure sciences,Vol. 22(2), (10-19).
Arjmamd F, Parveen S, Mohapatra DK (2012) Synthesis, characterization of Cu(11) and Zn (II) complexes of proline-glycine and proline-leucinetetrapeptides: In vitro DNA binding and cleavage studies. In Org. Chem. Acta, 388(15): 1-10
Devi, V., Kumari, N., & Awasthi, P. (2022). Synthesis, characterization and insect growth regulating study of beta-alanine substituted sulfonamide derivatives as juvenile hormone mimics. Phosphorus, Sulfur, and Silicon and the Related Elements, 1-11.
Wang, L., Mao, Y., Wang, Z., Ma, H., & Chen, T. (2021). Advances in biotechnological production of β-alanine. World Journal of Microbiology and Biotechnology, 37(5), 1-11.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
