A hormonal study of the effect of sesame oil in female albino rats whose ovaries had been removed
Keywords:
ovariectomy, sesame oil, hormones, ratsAbstract
This study was conducted to investigate the physiological effect of sesame seed oil (Sesamum indicum) in the case of oral treatment on post-menopause and the occurrence of surgical menopause as a result of the removal of the ovaries, by studying the changes in some hormones in the blood serum of adult female albino rats (Albino Rats). as 15 adult rats about three months old, with weights ranging from 160-180 g were used. The animals were randomly divided into three groups with five animals for each group. The first group represented the negative control, which was normal without removal of the ovaries, and the second represented the positive control that was removed The ovaries were completely removed, and the third group completely removed the ovaries and treated them orally with sesame oil at a concentration of 4 ml/ kg of body weight per day for 30 days. The results of laboratory tests for serum samples of the completely removed ovaries group compared to the negative control group showed a significant decrease (P<0.05) in the levels of estrogen and progesterone, while an insignificant increase )P (0.05<in prolactin levels was observed, and significant (P<0.05) for follicle-stimulating hormone (FSH) and luteal stimulating hormone (LH).
Downloads
References
Surh, Y.J. (2003). Cancer chemoprevention with dietary phytochemicals Nat. Rev. Cancer, 3:768-780.
Jayaraj, Premkumar & Aluganti, Chandrakala & Rajagopalan, Sanjay & Parthasarathy, Sampath & Desikan, Rajagopal. (2020). Sesamol: A powerful functional food ingredient from sesame oil for cardioprotection. Food & Function. 11(2): 1198-1210.
Morales, A. ; Vicente, C. ; Santiag, J. ; Egido, J. ; Mayoral, P. ; Arevalo, M. ; Fernandez, M. ; Lopez-Novoa, J. and Perez, F. (2006). Protective effect of quercetin on experimental chronic cadmium nephrotoxicity in rats is based on its antioxidant properties. Food and Chemical Toxicology. 44: 2092-2100.
Moazzami, A. and Kamal-Eldin, A. (2009). 8-Sesame seed oil. In: Moreau, R.A., Kamal- Eldin, A. (Eds.), Gourmet and Health-Promoting Specialty Oils. AOCS Press, pp. 267-282.
Bah kali, A. ; Hussain, M. and Basahy, A. (1998). Protein and oil composition of sesame seeds (Sesamum indicum, L.) grown in the Gizan area of Saudi Arabia. Inter. J. of Food Sci. and Nut., 49: 409-414.
Morris, J.B. (2002). Food, Industrial, Nutraceutical and pharmaceutical Uses of Sesame genetic resources. In J. Janick and A. Whipkey (eds). Trends in new Crops and new uses. ASHS Press, Alexandria,V.A.P: 153-156.
Amoo, S.O. ; Okorogbona, A.O.M. ; Du Plooy, C.P. and Venter, S.L. (2017). Sesamum indicum. In: Medicinal Spices and Vegetables from Africa. pp. 549-579.
Fuller, D.Q. (2003). Further evidence on the prehistory of sesame. Asian Agri-Hist. 7, 127-137.
Yavari, M. ; Rouholamin, S. ; Tansaz, M. and Esmaeili, S. (2016). Herbal Treatment of Oligomenorrhea with Sesamum indicum L.: A Randomized Controlled Trial. Galen Medical Journal, 5(3): 114-121.
Prasad, N.M. ; Sanjay, K.R. ; Deepika, S.P. ; Neha, V. ; Ruchika, K. and Nanjunda, S.S. (2012). A Review on Nutritional and Nutraceutical Properties of Sesame. Nutraceutical properties of sesame. Journal of Nutrition and Food Science, 2(127): 996-1000.
Mahabadi, A.J. ; Hassani, B.H. ; Nikzad, H. ; Taherian, A. ; Eskandarinasab, M. and Shaheir, M. (2012). Effect of a sesame seed regimen on the adult rat testicular structure. FEYZ; 16(4): 304-10.
Shittu, L.A. ; Shittu, R.K. and Ogundipe, O. (2009). Hypoglycaemia andimproved testicular parameters in Sesamum radiatum treated normo-glycaemic adult male Sprague Dawley rats. African J. of Biotechnol., 8(12): 2878-2886.
Hegde, D.M. (2012). Sesame. In: HandBook of Herbs and Spices. pp. 449-486.
Khan, A.V. ; Ahmed, Q.U. ; Khan, M.W. and Khan, A.A. (2014). Herbal cure for poisons and poisonous bites from Western Uttar Pradesh, India. Asian Pac. J. Trop. Dis. 4, S116-S120.
Kapoor, L. (2017). HandBook of Ayurvedic Medicinal Plants: Herbal Reference Library. Routledge.
AOAC (2005). Official methods of analysis (16th Ed.). Washington, DC: Association of Official Analytical Chemists.
Aref Salehzadeh ; Roghaye Abbasalipourkabir ; Behrooz Shisheian ; Ali Rafaat ; Ali Nikkhah and Tahereh Rezaii (2018). The alleviating effects of sesame oil on diazinon-induced toxicity in male wistar rats, Drug and Chemical Toxicology. DOI: 10.1080/01480545.2018.1449852.
Albozachri, J.M.K. ; Hameed, F.M. ; AL-Tomah, H.M. and Muhammid, H.A. (2017). Evaluation of tow general anesthetic regimeby use xylazine and ketamine with atropine and diazepam in rabbits. J. university of kerbala, 15: 21-30 .
Parhizkar, S. ; Ibrahim, R. and Abdul Latiff, L. (2008). Incision choice in laparatomy :A comparison of two incision techniques in ovariectomy of rats .World Appl. Sci. J., 4(4): 537-540.
Al-Rawi, humbled Mahmoud and Khalaf Allah, Abdul Aziz Muhammad (2000). Design and analysis of agricultural experiments, Ministry of Higher Education and Scientific Research. House of books for printing and publishing. University of Al Mosul. Second Edition. page 488.
Brijesh, K. (2013). Histology: Text & Atias (Female reproductive system), LiPpincott Williams & Wilkins: 284-288.
Berry, S.D. ; Jobst, P.M. ; Eillis, S.E. ; Howard, R . ; Capuco, A.V. and Akers, R.M. (2003). Mammary epithelial proliferation and estrogen receptor alpha expression in prepubertal Heifers: Effects of ovariectomy and growth hormone .J. Dairy Sci., 86(6): 2098-2105.
Parker, W. ; Jacoby, V. ; Shoupe, D. and Rocca, W. (2009). Effect of bilateral oophorectomy on women,s long-term health. Womens health (Lond Engl). (5): 565-76.
Hamed, G.M. ; Bahat, N.M. ; El-Agate, S.M.; Soliman, G.ZA. and Emara, M.M. (2010). Effect of asoy bean protein diet on Ovarectomised females albino rats subjected to myocardial Infarction. Singrpore. Med. J. 51(10): 781-789.
Yart, L. ; Dessauge, F. ; Finot, L. ; Barbey, S. ; Marnet, P.G. and Lollivier, V. (2012). Ovariectomy improves lactation persistency in dairy cows, J Dairy Sci. 95: 3794-3802.
Hadi, Humam Ali (2014). A biochemical, histological and genetic study on the effect of removing the ovaries on the brain and spinal cord of local female rabbits. Master Thesis. College of Education for Pure Sciences. Karbala University.
Al-Jubouri, Wafaa Issa (2006). Secondary amenorrhea and its relationship to the physiological and hormonal status of women. Master Thesis. College of Education, University of Tikrit: 28-30.
Kharode, Y.P. ; Sharp, M.C. and Bodine, P.V.N. (2008). Ovariectomized rat as a model for human osteoporosis in drug discovery. Meth. in Mol. Bio., 455: 111-124.
Al-Saadi, Reem Abdel Rahim Mardan (2012). Effect of ovaries removal and iron overload on some physiological and genetic parameters in adult female rabbits. Master Thesis. College of Education for Pure Sciences. Karbala University.
Schwatz ,P. (1992).The role of prophylactic oophorctomy in the avoidance of ovarian cancer. Int. J. Gynaecol .Obster. ; 39(3): 175-84.
Simpson, ER. (2000). Role of aromatase in sex steroid action. J Mol Endocrinol 25 (2): 149-156 .
Asuncion, M. ; Calvo, R.M. and San Millan, J.L. (2000). A prospective study of the prevalence of the polycystic ovary syndrome in unselected Caucasian women from Spain., J. Clin. Endocrinol. Metab., 85 (7): 2434-8.
Lane, D.E. (2006). Polycystic ovary syndrome and its differential diagnosis. Obstet. Gynecol. Surv. ; 61(2): 125-35.
Novais, S. ; Benetti-Pinto, C. and Garmes, H. (2015). Polycystic ovary syndrome and chronic autoimmune thyroiditis. Gynecol Endocrinal. Jan ; 31(1): 48-51.
Johnson, M.L. ; Redmer, D.A. and Reynolds, L.P. (1997). Effects of ovarian steroids on uterine growth , morphology and cell proliferation in ovariectomized, steroid-treated. Biol. Reprod. 57: 588-596.
Warren, M.P. and Stiehl, A.L. (1999). Exercise and female adolescents: effects on the reproductive and skeletal systems. Journal of the American Medical Women’s Association. 54(3): 115-120.
Montgomery Rice, V. ; Limback, SD. ; Roby, KF. and Terranova, PF. (2003). Differential responses of granulosa cells from small and large follicles to follicle stimulating hormone (FSH) during the menstrual cycle and acyclicity: effects of tumour necrosis factor- J., Hum Reprod. 13: 1285.
Lin, M. ; Wang, N. ; Yao, B. ; Zhong, Y. ; Lin, Y. ; and You, T. (2018). Quercetin
improves postpartum hypogalactia in milk-deficient mice via stimulating prolactin production in pituitary gland. Phytotherapy.
Tušimová, E. ; Packová, D. ; Kováčik, A. ; Ondruška, Ľ. ; Jurčík, R. and Kolesárová, A. (2017). Possible stimulatory effect of quercetin on secretion of selected pituitary hormones. Scientific Papers Animal Science and Biotechnologies, 50(1): 135-139.
Agiang, M. ; Olajumoke, J. ; Atangwho Item, J. and Ebong Patrick, E. (2015). Effect of some traditional edible oils on sex hormones of albino Wistar rats. African Journal of Biochemistry Research, 9: 40-46.
Gardner, D.G. and Shoback, D.M. (2018). Greenspan's Basic and Clinical Endocrinology, Tenth Edition (Greenspan's Basic and Clinical Endocrinology). 10th Edition. 92: 869.
RM, J. ; Anupama, S. and Aswathy, R.M. (2011). In Silico Techniques for the
Identification of Novel Natural Compounds for Secreting Human Breast
Milk. Web med Central BIOINFORMATICS, 2(8): WMC002131.
Martin, F. ; Stein, T. and Howlin, J. (2017). Mammary Gland Development : Methods and Protocols Springer New York.
Anagnostis, A. and Papadopoulos, A.I. (2009). Effects of a diet rich in sesame (Sesamum indicum) pericarp on the expression of oestrogen receptor alpha and oestrogen receptor beta in rat prostate and uterus. The British Journal of Nutrition, 102(5): 703-708.
Norman, A.W. and Henry, H.L. (2014). Hormones. 3rd Edition. Chennail, India.
Stanfield, L.C. (2013). Human Physiology (15th Ed.): 660-666.
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
