General neuropharmacological studies of piper betel leaves on mice
Keywords:
Piper betel, HPTLC, Acute ToxicityAbstract
The Piper betelplant is an evergreen and perennial creeper which is used in several traditional medicines to cure various diseases. The liquid extract of the plant has been used traditionally in curing inflammationand infection of the respiratory tract, cough, dyspnoea, indigestion,diphtheria, hysteria as well as general and sexual debility. The Indian traditional system ofmedicine has identified the Piper betelleaves with digestive and pancreatic lipasestimulant activities. In the present study, 14-day subacute toxicity assays were carried out.The crude extract did not produce toxic symptoms in mice in dose up to 2000mg/kg. This was also contirmed by hematological and histopathology examination.Piper betelshowed hypotensive, cardiac, and respiratory depressant effectssmooth and skeletal muscles relaxant actions, antimicrobial, fungicidal,and nematocidal activity.Piper betel leaves extract contains large number of bioactive molecule like polyphenol, alkaloids, steroids, saponin, and tannin.Alkaloid is the main constituent which is present in the extract has been detected by the Rf. values which were found from the TLC chromatography (HPTLC) has been performed.HPTLC also has been performed.
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