Iron oxide nanoparticles approaching to eradicate her2-positive breast cancer
A review
Keywords:
iron oxide nanoparticles, breast cancer, hyperthermia, photothermal therapy, MRI contrast agent, theranosticsAbstract
Background: Breast cancer is the second foremostreason for death in femalesuniversal. The enormously fast level of metastasis and capability to growconfrontationmethods to all the unoriginalmedications make them self-sameproblematic to indulgence which the reasons for in elevation morbidity and mortality are of breast melanoma patients. Expertsall through the world have been directing on the firstdiscovery of breast lump so that conduct can be started at the very primary stage. Furthermore, conventional treatment methods such as chemotherapy, radiotherapy, and local surgical treatmentsmart from innumerablerestrictions including toxicity, genetic mutation of normal cells, and spreading of cancer cells to healthy tissues. Therefore, new treatment schedules with low toxicity to usual cells need to be immediatelyadvanced. Methods: Iron oxide nanoparticles have remainedextensively used for targeting hyperthermia and imaging of breast growth cells. They can be conjugated with drugs, proteins, enzymes, antibodies, or nucleotides to bring them to target organs, tissues, or tumors using an external magnetic field. Results: Iron oxide nanoparticles have remainedpositively used as theranosticscauses for breast malignancy both in vitro and in vivo. Besides, their functions with medications or functional biomolecules increase their drug delivery efficiency and decrease the systemic noxiousness of drugs.
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