Prevalence of sickle cell disease among children in India
A systematic review and meta-analysis
Keywords:
sickle cell disease, children, systematic review, meta-analysis hematological disordersAbstract
Sickle Cell Anemia is a common hematological disorder affecting children, mostly from indigenous tribal populations in Africa and India. There is no synthesized evidence to inform policy on its prevalence and distribution across India. Therefore, this systematic review and meta-analysis aims to estimate and summarize the prevalence of Sickle Cell Disease (SCD) and Sickle Cell Trait (SCT) among children aged < 18 years in India. Following standardized methods of systematic reviews, a comprehensive search of all major medical databases was performed. Through independent stepwise screening, ten eligible studies were included in the study. Original peer-reviewed studies reporting the prevalence of either SCD or SCT among Indian children below 18 years of age were included for subsequent methodological quality assessment and data extraction using predefined standardized tools. Random and fixed effects models for meta-analysis were used to arrive at summary estimates for prevalence with 95% confidence intervals. Subgroup analysis was performed among tribal and non-tribal children. The included studies used data from around 2 million participants in total. The pooled prevalence of SCD among children in India is 0.8% (95% CI: 0.6-1.0%) and that of SCT was 9.2% (95% CI: 8.5-10.0%).
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