Association of the genetic variants of XRCC1 DNA repair gene as genetic factors for breast cancer in Iraqi patients
Keywords:
breast cancer, XRCC 1 Arg194Trp, polymorphism, IraqAbstract
Breast cancer (BC) is the second leading cause of cancer deaths worldwide and the most common type of cancer among women. This study was included blood of 75 Iraqi women with confirmed breast cancer and 25 samples with normal breast tissues were considered as control group. The restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) technique was performed the detection and genotyping for polymorphisms of X-Ray Repair Cross Complementing 1 (XRCC 1) gene Arg194Trp. The genotype distribution of the XRCC 1 Arg194Trp showed significant difference (p<0.05) between controls (Arg/Arg: n= 25, 100%; Arg/Trp and Trp/Trp n=0) and breast cancer patients (Arg/Arg: n= 47, 62.67%; Arg/Trp: n=2, 2.67%; Trp /Trp: n=26, 34.67%). The result showed an increased in Trp/Trp genotype and Trp allele of the XRCC1 Arg194Trp in breast cancer patients than control.
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