Study of association of C-reactive protein and alkaline phosphatase in type 2 diabetes mellitus patients

Dhone G. Pravin; Rathore Rajkumari; Gupta Vikas; Mohd Mubeen Faheem

doi:10.53730/ijhs.v6nS3.8844

Authors

Dhone Pravin G. Professor & Head, Department of Pharmacology, RSDKS GMC, Ambikapur
Rathore Rajkumari Associate Professor, Department of Biochemistry Bhima Bhoi Medical College Balangir
Gupta Vikas Critical Care Physician, Aureus Hospital, Nagpur
Mohd Mubeen Faheem Associate Professor, Department of Pharmacology, Ayaan Institute Of Medical Science Hyderabad

Keywords:

diabetes mellitus, inflammation, alkaline phosphates, strokes

Abstract

The prevalence and incidence of type 2 diabetes are rising rapidly worldwide, especially in Asia. Diabetes has been linked to a shorter life expectancy mainly because of its complications, including heart disease, strokes, eye disease, inflammation and bone disease. The aim of the study was to examine the relationship between high sensitive C reactive protein (hsCRP) and alkaline phosphatase (ALP) in type 2 diabetes patients. Furthermore, we investigated correlation between serum hsCRP and ALP level with glycaemic triad (FBS, PPBS, HbA1c) in case and control group. A cross sectional study consists of 200 patients out of which 100 normal healthy control (Group I), case - 100 patients having type 2 DM (Group II). FBS, PPBS, HbA1c, hsCRP and ALP were measured. Mean serum hsCRP and ALP level were statistically significantly higher in case group compared to control group. Moreover, significant positive correlation was observed between hsCRP and ALP level as well as both with FBS, PPBS and HbA1c. Oxidative stress and inflammation appears to be a key component and also associated with poor glycaemic control and further pathogenesis of diabetes and its complications.

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