Determination of cefdinir in pharmaceutical preparations by oxidative conjugation method
Keywords:
cefdinir, spectrophotometry, p-Aminobanzoicacid, 2,4-Dipyridin, N-Bromo SuccinimidAbstract
In order to detect of Cefidinir (CEF) in its pure form and in its pharmaceuticals have been devised the proposed methods were: (I) oxidative conjugation in an alkaline medium between (CEF) and regent "p-Aminobanzoicacid" to produce an intense yellow colored product, (II) oxidative conjugation between (CEF) and 2,4-Dipyridin in an alkaline medium to generate a bright golden yellow colored product. Absorption of the reagent p-Aminobanzoicacid is 0.589 in 467nm, and highest absorption of the reagent 2,4-Dipyridin is 0.851 in724 nm, with molar absorptivity of 4.99×104 Lmol.cm, and 9.25×104 Lmol.cm. The limits of detection (LOD) for p-Aminobanzoicacid" and 2,4-Dipyridin were found to be 0.033 g/ml, and 0.007 respectively. In both its pure form and pharmaceutical forms, the proposed approach was successful in estimating "This drug.."
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