Spectrophotometric determination of cefdinir in the pharmaceutical preparations
Keywords:
4-Chlorobanzaldehayde, Orthophenylenediamime, Cefdinir, SpectrophotometryAbstract
Two simple, quick, and sensitive techniques for spectrophotometric determination of Cefdinir (Cef) in its pure form and pharmaceutical formulations have been devised. The proposed methods were: (I) synthesis of a Schiff's base between Cefdinir and 4-Chlorobanzaldehayde reagent in an alkaline medium to produce a yellow-colored product, (II) diazotization and coupling between (Cef) and Orthophenylenediamime in an alkaline medium to produce an intense yellow colored product. The highest absorptions were measured at 0.568 with the reagent 4-Chlorobanzaldehayde and 0.871 with the reagent Orthophenylenediamime. Beer's Law holds true for 4-Chlorobanzaldehayde and Orthophenylenediamime at concentrations of (10-200g/ml), (10-135g/ml), respectively, with molar absorptivity of 105×1.35 Lmol.cm and 1.66×105 Lmol.cm. The limits of detection (LOD) for 4-Chlorobanzaldehayde and Orthophenylenediamime were found to be0.021 g/ml and 0.022 g/ml, respectively. The proposed method proved successful in estimating "This medication" in both its pure form and in pharmaceutical formulations.
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