Preparation, characterization and polymerization of some new compounds for esters derived from cephalosporins and some drugs, the study of some physical applications and evaluation of their biological activity

An'am Khalif Athab Al-Azzawi; Nabil Jamal Ayed, AlAsli

doi:10.53730/ijhs.v6nS1.8900

Authors

An'am Khalif Athab Al-Azzawi Chemistry Department - College of Education for Pure Sciences - Tikrit University. Salah Al-Din – Iraq
Nabil Jamal Ayed, AlAsli Chemistry Department - College of Education for Pure Sciences - Tikrit University. Salah Al-Din – Iraq

Keywords:

Cephalosporins, Esters, Enterococcus Faecalis, Staphylococcus Aureus, Klebsiella Pneumonia, Pseudomonas Putida

Abstract

In this research, esters and polymers were prepared and loaded from the reaction of cephalosporins with carboxylic acids and their interaction with polyvinyl alcohol by the sublimation method. During spectroscopic measurements, including Uv, FTIR, ¹H-NMR, ¹³C-NMR, mass spectrometry, elemental microanalysis, scanning electron microscopy (S.E.M.) analysis, and microanalysis for the elements (C.H.N.), the electrical conductivity and the biological activity of some prepared compounds and on four types of pathogenic bacteria were studied, two of them were Gram-positive, and two were negative. (Gram-negative), which are (Staphylococcus aureus, Enterococcus faecalis, Klebsiella pneumonia, and Pseudomonas putida), and the use of the Acker Muller-Hinton culture medium (Molar Huntin Agar) Aqueous solutions of the two compounds [DM26, DM18] with concentrations (0.01,0.001,0.0001,0.00001) mg/ml were also prepared using a dimethyl solvent. Sulfoxide (DMSO) The sensitivity test of bacterial isolates used in the study was conducted by diffusion method, and the antibiotics Cefixime, Ceftriaxone, and Ampicillin were used as a control sample.

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References

Adams, P., & Baron, F. A. (1965). Esters of carbamic acid. Chemical Reviews, 65(5), 567-602.‏

Fang, T., & Shimp, D. A. (1995). Polycyanate esters: science and applications. Progress in Polymer Science, 20(1), 61-118.‏

Wang, Y., Noble, A., Myers, E. L., & Aggarwal, V. K. (2016). Enantiospecific alkynylation of alkylboronic esters. Angewandte Chemie, 128(13), 4342-4346.‏

Gao, B., Li, Y., Huang, G., & Yu, L. (2019). Fatty acid esters of 3-monochloropropanediol: a review. Annual review of food science and technology, 10, 259-284.‏

Murarka, S. (2018). N‐(acyloxy) phthalimides as redox‐active esters in cross‐coupling reactions. Advanced Synthesis & Catalysis, 360(9), 1735-1753.‏

Pantelaki, I., & Voutsa, D. (2020). Occurrence, analysis and risk assessment of organophosphate esters (OPEs) in biota: a review. Marine Pollution Bulletin, 160, 111547.‏

Lu, B., Cheng, Y., Chen, L. Y., Chen, J. R., & Xiao, W. J. (2019). Photoinduced copper-catalyzed radical aminocarbonylation of cycloketone oxime esters. ACS Catalysis, 9(9), 8159-8164.‏

Abd, I. Q., Ibrahim, H. I., Jirjes, H. M., & Dalaf, A. H. (2020). Synthesis and Identification of new compounds have Antioxidant activity Beta-carotene, from Natural Auxin Phenyl Acetic Acid. Research Journal of Pharmacy and Technology, 13(1): 40-46.‏

Jabar, S. A., Hussein, A. L., Dalaf, A. H., & Aboud, H. S. (2020). Synthesis and Characterization of Azetidine and Oxazepine Compounds Using Ethyl-4-((4-Bromo Benzylidene) Amino) Benzoate as Precursor and Evalution of Their Biological Activity. Journal of Education and Scientific Studies, 5(16).‏

Dalaf, A. H. (2018). Synthesis and Characterization of Some Quartet and Quinary Hetero cyclic Rings Compounds by Traditional Method and Microwave Routes Method and Evaluation of Their Biological Activity. M.Sc. Thesis, Tikrit University, Tikrit, Iraq: 1-94 pp.

Dalaf, A. H., & Jumaa, F. H. (2018). Synthesis, Characterization of some 1,3-Oxazepane -4,7-Dione by Traditional and Microwave routes method and evaluation of their biological activity. Al-utroha for Pure Science. (8): 93-108.

Dalaf, A. H., Jumaa, F. H., & Jabbar, S. A. S. (2018). Synthesis and Characterization of some 2, 3-dihydroquinozoline and evaluation of their biological activity. Tikrit Journal of Pure Science, 23(8): 66-67.‏

Salwa, A. J., Ali, L. H., Adil, H. D., Hossam, S. A. (2020). Synthesis and Characterization of Azetidine and Oxazepine Compounds Using Ethyl-4-((4-Bromo Benzylidene) Amino) Benzoate as Precursor and Evalution of Their Biological Activity. Journal of Education and Scientific Studies, ISSN: 24134732. 16(5): 39-52.

Dalaf, A. H., & Jumaa, F. H. (2020). Synthesis, Identification and Assess the Biological and Laser Efficacy of New Compounds of Azetidine Derived from Benzidine. Muthanna Journal of Pure Science (MJPS), 7(2):12-25.

Saleh, R. H., Rashid, W. M., Dalaf, A. H., Al-Badrany, K. A., & Mohammed, O. A. (2020). Synthesis of Some New Thiazolidinone Compounds Derived from Schiff Bases Compounds and Evaluation of Their Laser and Biological Efficacy. Ann Trop & Public Health, 23(7): 1012-1031.‏

Yass, I. A., Aftan, M. M., Dalaf, A. H., & Jumaa, F. H. (Nov. 2020). Synthesis and Identification of New Derivatives of Bis-1,3-Oxazepene and 1,3-Diazepine and Assess the Biological and Laser Efficacy for Them. The Second International & The Fourth Scientific Conference of College of Science – Tikrit University. (P4): 77-87.

Salih, B. D., Dalaf, A. H., Alheety, M. A., Rashed, W. M., & Abdullah, I. Q. (2021). Biological activity and laser efficacy of new Co (II), Ni (II), Cu (II), Mn (II) and Zn (II) complexes with phthalic anhydride. Materials Today: Proceedings, 43, 869-874.

Aftan, M. M., Jabbar, M. Q., Dalaf, A. H., & Salih, H. K. (2021). Application of biological activity of oxazepine and 2-azetidinone compounds and study of their liquid crystalline behavior. Materials Today: Proceedings, 43, 2040-2050.‏

Aftan, M. M., Talloh, A. A., Dalaf, A. H., & Salih, H. K. (2021). Impact para position on rho value and rate constant and study of liquid crystalline behavior of azo compounds. Materials Today: Proceedings.‏

Nyandra, M., Kartiko, B.H., Susanto, P.C., Supriyati, A., Suryasa, W. (2018). Education and training improve quality of life and decrease depression score in elderly population. Eurasian Journal of Analytical Chemistry, 13(2), 371-377.

Aftan, M. M., Toma, M. A., Dalaf, A. H., Abdullah, E. Q., & Salih, H. K. (2021). Synthesis and Characterization of New Azo Dyes Based on Thiazole and Assess the Biological and Laser Efficacy for Them and Study their Dyeing Application. Egyptian Journal of Chemistry, 64(6), 2903-2911.‏

Nyandra, M., Kartiko, B.H., Susanto, P.C., Supriyati, A., Suryasa, W. (2018). Education and training improve quality of life and decrease depression score in elderly population. Eurasian Journal of Analytical Chemistry, 13(2), 371-377.

Khalaf, S. D., Ahmed, N. A. A. S., & Dalaf, A. H. (2021). Synthesis, characterization and biological evaluation (antifungal and antibacterial) of new derivatives of indole, benzotriazole and thioacetyl chloride. Materials Today: Proceedings.‏ 47(17), 6201-6210.

Dalaf, A. H., Jumaa, F. H., & Salih, H. K. (2021). Preparation, Characterization, Biological Evaluation and Assess Laser Efficacy for New Derivatives of Imidazolidin-4-one. International Research Journal of Multidisciplinary Technovation, 3(4), 41-51.‏

Dalaf, A. H., Jumaa, F. H., & Salih, H. K. (2021). MULTIDISCIPLINARY TECHNOVATION. Red, 15(A2), C44H36N10O8.‏

Dalaf, A. H., Jumaa, F. H., Aftana, M. M., Salih, H. K., & Abd, I. Q. (2022). Synthesis, Characterization, Biological Evaluation, and Assessment Laser Efficacy for New Derivatives of Tetrazole. In Key Engineering Materials (Vol. 911, pp. 33-39). Trans Tech Publications Ltd.‏