Immunological, bacteriological and genetic factors may modulate the risk of gallbladder disease among Iraqi patients
Keywords:
cholecystitis, gallstone, IL-1α, visfatinAbstract
Background:. Gallstone disease(GSD) is a prevalent illness worldwide. Patients and methods: During a duration of 3 months October/2020 to December /2021, samples were collected from160 patients diagnosed with gallstone disease by Ultrasound method, and 60 healthy individuals, who were attended Safer Al-Hussein Surgical Hospital /Karbala and Imam Al-Hussein Medical –City /Karbala. The specimens were collected from bile and an inner surface of the gallbladder with aseptically. The specimens were treated immediately after they reach to the laboratory following the standard laboratory procedures. The patient were examined by the surgery specialist. Results: resulting data shows a considerable variance (P < 0.05) between the condensation for IL_1 α in the blood of patients and healthy people, and there is a non-considerable difference (P > 0.05) in the concentration from VP in sera of subjects tested. Conclusion: elevation in IL-1α-level and a non-considerable difference in VP condensation.
Downloads
References
Huffman, J.L. and S. Schenker, Acute acalculous cholecystitis: a review. Clinical Gastroenterology and Hepatology, 2010. 8(1): p. 15-22.
Strasberg, S.M., Acute calculous cholecystitis. New England Journal of Medicine, 2008. 358(26): p. 2804-2811.
Ali, R.A., H.R. Khudhur, and A.A. Hasan, Microbiology and histological study of gallbladder among acute and chronic cholecystitis in Babylon City, Iraq. Reviews in Medical Microbiology, 2021. 32(2): p. 95-101.
Mills, J., T. Stappenbeck, and N. Bunnett, Gastrointestinal disease. Pathophysiology of Disease: An Introduction to Clinical Medicine. 6th ed. New York, NY: McGraw-Hill Medical, 2010.
Mahdi, B.M., Immunogenetic basis of cholecystitis, in Updates in Gallbladder Diseases. 2017, IntechOpen.
Chuang, S.-C., E. Hsi, and K.-T. Lee, Genetics of gallstone disease. Advances in clinical chemistry, 2013. 60: p. 143-185.
Wang, H.H., P. Portincasa, and D.Q. Wang, Molecular pathophysiology and physical chemistry of cholesterol gallstones. Frontiers in Bioscience-Landmark, 2008. 13(2): p. 401-423.
Srivastava, A., et al., Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India. Journal of gastroenterology and hepatology, 2010. 25(11): p. 1758-1762.
Abayli, B., et al., Helicobacter pylori in the etiology of cholesterol gallstones. Journal of clinical gastroenterology, 2005. 39(2): p. 134-137.
Huan, P., et al., TLR4 expression in normal gallbladder, chronic cholecystitis and gallbladder carcinoma. Hepato-gastroenterology, 2012. 59(113): p. 42-46.
Dinarello, C.A., Interleukin 1 and interleukin 18 as mediators of inflammation and the aging process. The American journal of clinical nutrition, 2006. 83(2): p. 447S-455S.
Rege, R.V., Inflammatory cytokines alter human gallbladder epithelial cell absorption/secretion. Journal of Gastrointestinal Surgery, 2000. 4(2): p. 185-192.
Kasprzak, A., et al., Analysis of immunohistochemical expression of proinflammatory cytokines (IL-1α, IL-6, and TNF-α) in gallbladder mucosa: comparative study in acute and chronic calculous cholecystitis. Folia morphologica, 2015. 74(1): p. 65-72.
Kishimoto, T., IL-6: from its discovery to clinical applications. International immunology, 2010. 22(5): p. 347-352.
Issa, A.H. and M. Muthena, Serum levels of several types of cytokines associated with Chronic Cholecystitis in Basrah/south of Iraq. Basrah J. Sci, 2014. 32: p. 248-280.
Zhong, G., et al., Clinical acupuncture therapy for chronic cholecystitis: A protocol for systematic review and meta-analysis. Medicine, 2021. 100(10).
Park, J.W., et al., Serum level of visfatin can reflect the severity of inflammation in patients with acute cholecystitis. Annals of Surgical Treatment and Research, 2020. 99(1): p. 26.
Xie, K.-G., et al., Elevated plasma visfatin levels correlate with conversion of laparoscopic cholecystectomy to open surgery in acute cholecystitis. Peptides, 2014. 60: p. 8-12.
Pérez-Moreno, P., et al., Environmental and Lifestyle Risk Factors in the Carcinogenesis of Gallbladder Cancer. Journal of Personalized Medicine, 2022. 12(2): p. 234.
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). The COVID-19 pandemic. International Journal of Health Sciences, 5(2), vi-ix. https://doi.org/10.53730/ijhs.v5n2.2937
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
