Study of some immunological parameters in hematological malignancies patients
Keywords:
immunological parameters, hematological malignancies, patientsAbstract
This study aimed to verify the number of differentiation aggregates that include HLA-DR, CD5 and CD7 In patients with hematological malignancies and comparing them with the healthy group, where the levels of these subgroups were detected in the peripheral blood of 40 males and females, Where samples were collected by 20 samples from patients with malignant hematomas, Plus 20 people from the healthy group.All blood samples and available data were collected from patients with hematological malignancies, from the Center for Oncology and Hematology,in partnership with the laboratories of medical centers and Al-Jawadeen National Laboratory, for the period from November 2021 to May 2022.The immunophenotypes of HLA-DR, CD5 and CD7 were studied in the samples using the flow cytometry technique,where the rate of differentiation aggregates in patients with leukemia was much higher than in healthy people, where the results showed significant differences with statistical significance at the level of P≤ 0.05 in the proportion of CD5, CD7 and HLA-DR in samples of patients with hematological malignant diseases, and a slight increase in the level of CD5 and HLA-DR was found in males than in females, and a slight decrease in the level of CD7 was observed in males than in females.
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