Association between zinc deficiency and obesity among a sample of adult in Al-Najaf city, Iraq

https://doi.org/10.53730/ijhs.v6nS5.9491

Authors

  • Sabreen Ali Hassouni M.sc, Student Department of Community Health Techniques, Al Najaf Health Directorate, Iraq
  • Jabbar Taresh Ahmed PhD. Assistant Professor, Southern Technical University/College of Health & Medical Technology, Basra, Iraq
  • Salam Jasim Mohammed PhD. Professor, College of Medicine, University of Kufa, Najaf, Iraq
  • Ahmed A. Mohammed Alshamarti M.sc, Student Department of Community Health Techniques, Al Najaf Health Directorate, Iraq

Keywords:

Obesity, serum zinc, BMI and case-control study

Abstract

Background: Obesity has become a major health problem, defined as an abnormal or excessive accumulation of fat in adipose tissue and is diagnosed with a BMI ≥30 kg/m2. The study aimed to find the correlation between zinc deficiency and obesity, also, to study the association between obesity and different socio-demographic factors. Material and Methods: A case-control study was conducted to achieve the aims of the study that has been conducted from the beginning of December 2021 until June 2022. The size of the sample comprises 140 participants who were equally divided into two groups, obese group (body mass index (BMI) ≥ 30 kg/m2) and the control group, (BMI18.5 - 24.9 kg/m2). All participants were taken randomly from adult peoples ages ranged between (18-65) years in Al-Najaf Governorate. Results: The association between serum zinc and obesity was significant (p-value = 0.041, O. ratio (95%CI) = 2.01(1.02-3.97)). The correlation between serum zinc level with both BMI and waist hip ratio (WHR) was negatively correlation (r = -0.241, r = -0.033, respectively). The association between obesity and socio-demographics characteristics was only significant with gender and marital status (P-value =0.002, 0.016, respectively), while the other characteristics were not significant (p-value = >0.05).

Downloads

Download data is not yet available.

References

Blüher M. Obesity: global epidemiology and pathogenesis. Nat Rev Endocrinol. 2019;15(5):288–98.

Rizzuto D, Fratiglioni L. Lifestyle factors related to mortality and survival: a mini-review. Gerontology. 2014;60(4):327–35.

(WHO) WHO. Obesity and Overweight. 9 June 2021. URL https//www who int/en/news-room/fact-sheets/detail/obesity-and-overweight (дата обращения 0209 2021). 2021;

Amin MN, Siddiqui SA, Uddin MG, Ibrahim MD, Uddin SMN, Adnan MT, et al. Increased oxidative stress, altered trace elements, and macro-minerals are associated with female obesity. Biol Trace Elem Res. 2020;197(2):384–93.

Shabu SA. Prevalence of overweight/obesity and associated factors in adults in Erbil, Iraq: A household survey. Zanco J Med Sci (Zanco J Med Sci). 2019;23(1):128–34.

Mansour AA, Al-Maliky AA, Salih M. Population overweight and obesity trends of eight years in Basrah, Iraq. Epidemiol. 2012;2(110):1165–2161.

Jasim HM, Hussein HMA, Al-Kaseer EA. Obesity among females in Al-Sader city Baghdad, Iraq, 2017. J Fac Med Baghdad. 2018;60(2):105–7.

Chasapis CT, Ntoupa P-SA, Spiliopoulou CA, Stefanidou ME. Recent aspects of the effects of zinc on human health. Arch Toxicol. 2020;94(5).

McClung JP. Iron, zinc, and physical performance. Biol Trace Elem Res. 2019;188(1):135–9.

King JC, Brown KH, Gibson RS, Krebs NF, Lowe NM, Siekmann JH, et al. Biomarkers of Nutrition for Development (BOND)—zinc review. J Nutr. 2015;146(4):858S-885S.

Grüngreiff K, Gottstein T, Reinhold D. Zinc Deficiency—An Independent Risk Factor in the Pathogenesis of Haemorrhagic Stroke? Nutrients. 2020;12(11):3548.

Warthon-Medina M, Moran VH, Stammers AL, Dillon S, Qualter P, Nissensohn M, et al. Zinc intake, status and indices of cognitive function in adults and children: a systematic review and meta-analysis. Eur J Clin Nutr. 2015;69(6):649–61.

White JVJ. V, Guenter PP, Jensen GG, Malone AA, Schofield MM. Consens statement Acad Nutr Diet Am Soc Parenter Enter Nutr Charact Recomm Identif Doc adult malnutrition (undernutrition) JPEN J Parenter Enter Nutr. 2012;36:275–83.

Wessels I, Rink L. Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D. J Nutr Biochem. 2020;77:108240.

Maxfield L, Crane JS. Zinc deficiency. StatPearls [Internet]. 2020;

Nasiri-Babadi P, Sadeghian M, Sadeghi O, Siassi F, Dorosty A, Esmaillzadeh A, et al. The association of serum levels of zinc and vitamin D with wasting among Iranian pre-school children. Eat Weight Disord Anorexia, Bulim Obes. 2021;26(1):211–8.

World Health Organization. Obesity and overweight [Internet]. 2022 [cited 2022 Jan 2]. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

Boon NA. Davidson’s principles and practice of medicine. Churchill Livingstone; 2006.

Hotz C, Peerson JM, Brown KH. Suggested lower cutoffs of serum zinc concentrations for assessing zinc status: reanalysis of the second National Health and Nutrition Examination Survey data (1976–1980). Am J Clin Nutr. 2003;78(4):756–64.

Makino T. A sensitive, direct colorimetric assay of serum zinc using nitro-PAPS and microwell plates. Clin Chim acta. 1991;197(3):209–20.

Pengpid S, Peltzer K. Overweight and obesity among adults in Iraq: prevalence and correlates from a National Survey in 2015. Int J Environ Res Public Health. 2021;18(8):4198.

Okati-Aliabad H, Ansari-Moghaddam A, Kargar S, Jabbari N. Prevalence of Obesity and Overweight among Adults in the Middle East Countries from 2000 to 2020: A Systematic Review and Meta-Analysis. J Obes. 2022;2022.

Ustu Y, Ugurlu M, Aslan O, Aksoy YM, Kasim I, Egici MT, et al. High prevalence of obesity in Tokat, a northern province of Turkey. JPMA. 2012;62(435).

Arrar AA, Shamkh SS, Hussein HA. Correlation Between Obesity and Dietary Habit of the Adult Client at Out-Patient Clinic in Qalat Saleh City/Iraq. Bahrain Med Bull. 2021;43(4).

Thamrin SA, Arsyad DS, Kuswanto H, Lawi A, Nasir S. Predicting Obesity in Adults Using Machine Learning Techniques: An Analysis of Indonesian Basic Health Research 2018. Front Nutr. 2021;8.

Abdullah SR, Saleh KK, Khudhir KM, Mahmood KA, Hamarashid BR. Prevalence of obesity-associated with health issues among Koya Technical Institutes Staff in Kurdistan Region, Iraq. Zanco J Pure Appl Sci. 2021;33(1):113–9.

Tittlbach SA, Hoffmann SW, Bennie JA. Association of meeting both muscle strengthening and aerobic exercise guidelines with prevalent overweight and obesity classes-results from a nationally representative sample of German adults. Eur J Sport Sci. 2022;22(3):436–46.

Shephard RJ. The efficacy of exercise in the treatment of established obesity. Heal Fit J Canada. 2019;12(3):93–165.

Rios-Lugo MJ, Madrigal-Arellano C, Gaytán-Hernández D, Hernández-Mendoza H, Romero-Guzmán ET. Association of serum zinc levels in overweight and obesity. Biol Trace Elem Res. 2020;198(1):51–7.

Chen M-D, Lin PY, Lin WH, Cheng V. Zinc in hair and serum of obese individuals in Taiwan. Am J Clin Nutr. 1988;48(5):1307–9.

García OP, Ronquillo D, Caamaño M del C, Camacho M, Long KZ, Rosado JL. Zinc, vitamin A, and vitamin C status are associated with leptin concentrations and obesity in Mexican women: results from a cross-sectional study. Nutr Metab (Lond). 2012;9(1):1–9.

Azab SFA, Saleh SH, Elsaeed WF, Elshafie MA, Sherief LM, Esh AMH. Serum trace elements in obese Egyptian children: a case–control study. Ital J Pediatr. 2014;40(1):1–7.

Crujeiras AB, Carreira MC, Cabia B, Andrade S, Amil M, Casanueva FF. Leptin resistance in obesity: An epigenetic landscape. Life Sci. 2015;140:57–63.

Jung CH, Kim M-S. Molecular mechanisms of central leptin resistance in obesity. Arch Pharm Res. 2013;36(2):201–7.

Myers Jr MG, Leibel RL, Seeley RJ, Schwartz MW. Obesity and leptin resistance: distinguishing cause from effect. Trends Endocrinol Metab. 2010;21(11):643–51.

Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, et al. Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes. 2001;50(2):227–32.

Habib SA, Saad EA, Elsharkawy AA, Attia ZR. Pro-inflammatory adipocytokines, oxidative stress, insulin, Zn and Cu: Interrelations with obesity in Egyptian non-diabetic obese children and adolescents. Adv Med Sci. 2015;60(2):179–85.

Iuliano L. Pathways of cholesterol oxidation via non-enzymatic mechanisms. Chem Phys Lipids. 2011;164(6):457–68.

Zavala G, Long KZ, García OP, del Carmen Caamaño M, Aguilar T, Salgado LM, et al. Specific micronutrient concentrations are associated with inflammatory cytokines in a rural population of Mexican women with a high prevalence of obesity. Br J Nutr. 2013;109(4):686–94.

Cayir Y, Cayir A, Turan MI, Kurt N, Kara M, Laloglu E, et al. Antioxidant status in blood of obese children: the relation between trace elements, paraoxonase, and arylesterase values. Biol Trace Elem Res. 2014;160(2):155–60.

Gu K, Xiang W, Zhang Y, Sun K, Jiang X. The association between serum zinc level and overweight/obesity: a meta-analysis. Eur J Nutr. 2019;58(8):2971–82.

Marreiro D do N, Geloneze B, Tambascia MA, Lerário AC, Halpern A, Cozzolino SMF. Effect of zinc supplementation on serum leptin levels and insulin resistance of obese women. Biol Trace Elem Res. 2006;112(2):109–18.

Konukoglu D, Turhan MS, Ercan M, Serin O. Relationship between plasma leptin and zinc levels and the effect of insulin and oxidative stress on leptin levels in obese diabetic patients. J Nutr Biochem. 2004;15(12):757–60.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Tascilar ME, Ozgen IT, Abaci A, Serdar M, Aykut O. Trace elements in obese Turkish children. Biol Trace Elem Res. 2011;143(1):188–95.

Weiderpass E, Botteri E, Longenecker JC, Alkandari A, Al-Wotayan R, Al Duwairi Q, et al. The prevalence of overweight and obesity in an adult Kuwaiti population in 2014. Front Endocrinol (Lausanne). 2019;449.

Wido, A., Bajamal, A. H., Apriawan, T., Parenrengi, M. A., & Al Fauzi, A. (2022). Deep vein thrombosis prophylaxis use in traumatic brain injury patients in tropical climate. International Journal of Health & Medical Sciences, 5(1), 67-74. https://doi.org/10.21744/ijhms.v5n1.1840

Lima Y de MM, Martins FA, Ramalho AA. Factors Associated with Overweight and Obesity in Adults from Rio Branco, Acre in the Western Brazilian Amazon. Nutrients. 2022;14(5):1079.

Published

22-06-2022

How to Cite

Hassouni, S. A., Ahmed, J. T., Mohammed, S. J., & Alshamarti, A. A. M. (2022). Association between zinc deficiency and obesity among a sample of adult in Al-Najaf city, Iraq. International Journal of Health Sciences, 6(S5), 3940–3951. https://doi.org/10.53730/ijhs.v6nS5.9491

Issue

Section

Peer Review Articles