Assessment of cytokine profile in rheumatoid arthritis patients
Keywords:
Rheumatoid arthritis, IL-6, TNF-α, CRP, ESR, anti-ccpAbstract
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that primarily affects small joints, characterized by inflammation and cellular proliferation in the synovial lining of joints that can ultimately result in cartilage and bone destruction. This study aims to detect the IL-6 and TNF –α in addition to assess some diagnostic parameters in105 Rheumatoid arthritis patients and compared with healthy individuals as control. The mean level of ESR and CRP in RA patients were increase significantly (P<0.05) in (81.25±14.35 and 224 ± mg/dl), respectively than control. The mean IL-6 and TNF-α serum level were significantly higher (p ≤0.05) in RA patients (197 & 308) pg/ml, respectively compared to the control (5 & 57) pg./ml. There was no significant correlation between anti-CCP with RF, IL-6, TNF-α (p≥0.05) and only significant with RA33.
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