Analysis of copper and zinc levels in the mucosal tissue and serum of oral submucous fibrosis patients

Dushyantsinh Vala; Mimansha Patel; Krishana Gopal; Kartikay Saxena; Preeti Dhir; Uday N. Patel

doi:10.53730/ijhs.v6nS6.10121

Authors

Dushyantsinh Vala Tutor, Dept. of Oral & Maxillofacial Pathology and Oral Microbiology, Government Dental College & Hospital, Jamnagar, Gujarat, India
Mimansha Patel Professor, Department of Oral Pathology and Microbiology, Triveni Dental College, Bodri, Bilaspur, Chhattisgarh, India
Krishana Gopal Associate Professor, Department of Biochemistry, LLRM Medical College, Meerut, U.P, India
Kartikay Saxena Professor, Dept of Oral Pathology and Microbiology,New Horizon Dental College and Research Institute, Sakri, Bilaspur Chhattisgarh, India
Preeti Dhir Professor, Dept of Oral Medicine and Radiology, Dasmesh Institute of Research and Dental Sciences, Faridkot, Punjab, India
Uday N. Patel Professor & HOD, Department of Oral & Maxillofacial Pathology, Goenka Research Institute of Dental Science, Gandhinagar, Gujarat, India

Keywords:

copper, zinc, oral submucous fibrosis, trace elements

Abstract

Background and Objectives:Although the pathogenesis of oral submucous fibrosis (OSMF) has been studied, it remains unclear whether or not this illness might progress to malignancy. The pathogenesis of the illness may be better understood by measuring copper and zinc levels in tissue and serum from these people. Because of the widespread cultural and social usage of areca nuts in India, a research was conducted to investigate their concentrations in this population. Methods:Twenty people with OSMF and twenty people without it were studied in a case-control fashion. Copper and zinc concentrations were measured in the 40 patients' tissues and blood using colorimetry. Compared to the zinc concentration of 25.18 4.92 g/gm found in OSMF group tissues, copper concentration was 4.31 1.13 g/gm. Zinc levels were 0.92 0.18 g/ml and serum copper levels were 1.00 0.20 g/ml on average in the OSMF group. Interpretation and conclusion:OSMF group tissue zinc levels were substantially different from control group levels (p = 0.009), as were OSMF group tissue copper levels (p = 0.001). There was no statistically significant difference in serum copper (p = 0.35) or zinc (p = 0.08) between the experimental and control groups.

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