Study of biochemical parameters with insulin resistance type 2 diabetes mellitus subjects

https://doi.org/10.53730/ijhs.v6nS5.10631

Authors

  • Krishana Gopal Associate Professor, Department of Biochemistry LLRM Medical College, Meerut U.P (250004)
  • Pushpraj Singh Senior Resident, Department of Dentistry, Govt. Medical College, Shahdol. (MP)
  • Akhilesh Singh Parate Senior Resident, Department of Dentistry Govt. Medical College, Shahdol
  • Divya Shukla Tutor, Department of Biochemistry, LLRM Medical College, Meerut U.P 250004
  • Neha Agrawal Reader, Department of Conservative Dentistry and Endodontics, New Horizon Dental College Reserach institute, Sakri, Bilaspur, Chhattisgarh
  • Padmaksha Laskar PG student, Department of Prosthodontics and crown and bridge and oral implantology, New Horizon Dental College and Research institute, Sakri, Bilaspur, Chhattisgarh

Keywords:

biochemical, insulin resistance, type 2 diabetes mellitus

Abstract

Introduction: Diabetes results from hyperglycemia and improper glucose, lipid, and protein metabolism. The elderly population will quadruple in 10 years. LMICs have the highest type 2 DM patients. Insulin resistance and beta cell abnormalities cause T2DM. This study compared HbA1c, FPG, and lipids to controls. Materials and methods: The study was carried out in the Department of Biochemistry L.LRM Medical College, Meerut. The study was done on 250 individuals, who included 100 uncontrolled type-2 diabetic (Group III), 100 controlled type-2 diabetic (Group II) and 50 healthy individuals (Group I). Blood biochemistry and immunology for various parameters such as Fasting Blood Sugar (FBS), Glycosylated haemoglobin (HbA1c), Total Cholesterol (TC), Triglyceride (TG), High density-lipoprotein cholesterol (HDL-c), Low density lipoprotein cholesterol (LDL-c), Very low density lipoprotein cholesterol (VLDL-c), Urea, Creatinine were carried out for all three groups. SPSS16.0 was used to analyse the results. Results: In our study we found highly significant increase (P< 0.001) of fasting blood sugar and glycosylated hemoglobin levels in group II and group III as compared to group I. In the present study, the patterns of lipid profile parameters in type-2 diabetic subjects were also studied.

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References

Abdul Fatai B .Olokoba .Divison Of Gastroenterology Department Of Medicine.

American Diabetes Association ;Standards Of Medical Care For Patients With Diabetes Mellitus (Position Statement ) Diabetes Care 26 (Suppl.1) 533-5-49 2003

American Diabetes Association 2008 Base Jb . Department Of Medicine American .

Anabela P, Rolo Carlos M, Palmeira ,Diabetes And Mitochondrial Function ;Role Of Hyperglycemia And Oxidative Stress . Toxicologly And Applied Pharmacology 2006, 212;167-178

Astrid Kolder And Birger Svinus Faculty Of Public Health ,Hedmark University College P.O Box 400 2418elvervm Norway ,Norwegian University Of Life Scinces. P.O Box 5003 1432 Aas Norway

Bhanu Kumar Muthiah , Adarsh L.S Naveen Krishna Peddi , Vineetha Bharathan Mrnon Department Of Internal Medicine ,Jss Medical College Mysore India .

Bloomgarden Zt. Cardiovascular Diseases And Diabetes And Diabetes Care 2003;26;2302

Cornelius P ,Marlowe M , Lee Md Pekala Ph .The Growth Factor ,Like Effect Of Tumar Necrosis Factor –Alpha . Stimulation Of Glucose Transport Activity And Induction Of Glucose Transporter And Immediate Early Gene Expression In 3t –L1 Preadipocytes ,J Bio 1 Chem. 1991; 265;20506-20516.

Deepthi B , Sowjanya K , Lidiya B , Bhargavi Rs And Babu Ps Department Of Pharmacology ,Vignann Pharmacy College Vadalmudi , India .

Henegar Jr , Bigler Sa Henegar Lk Tygi Sc , Hall Je . Functional And Structural Changes In The Kidney In The Early Stages Of Obesity .Journal Of American Society Of Nephrology .2001

J.L Patel ,Amsuthar, Vb Ddalsaniya, Ap Parikh, Nnsutharr ,Kl Patez . Third Report Of National Cholesterol Education Program (Ncep) Expert Panel On Detection Evaluation And Treatment Of High Blood Cholesterol In Adult (Adults Treatment Panel ) Executive Summary Publication No 01-3670 Bethesda National Institutus Of Healt ,2001

King Gl, Role Of Inflammatory Cytokines In Diabetes, J Periodontal. 2008; 79:1527-1534.

Laura M.C Welschen ,Msc Coster S , Gulliford Mc ,Seed Pt , Powrie Jk Swaminathan .R ;Monitoring Blood Glucose Control In Diabetes Mellitus ; A Systematic Review .Health Technology Asses. 4;1-4 1-932000.

Marti Alamos .Jimenez Sorriano Y. Sarrrrion Perez M.G Dental Considerations For The Patient With Diabetes .J Clin Exp Dent 2011;E25-30 Http//Www.Medicinaoral.Com/Odo/Volumenes/V3i/P25 Pdf .

Opera E.C Oxidative Stress ,Micronutrients Diabetes Mellitus And Its Complication; Jr Soc Heath . 20022;122 ;28-34.

Ram Vinod Mahato, Prajwal Gyawali Pramod. Psd. Raut Prashant Regmi Khelanand Psd.Singh Dipendra Raj Pandeya, Prabin Gyawali. Association Between Glycemic Control And Serum Lipid Profile In Type -2 Diabetic Patients Glycated Haemoglobin As A Dual Biomarker .Biomedical Research 2011,22(3)375-380

Saraswati, P. A. I. ., Gunawan, I. M. K., & Budiyasa, D. G. A. (2021). Overview of glomerulus filtration in type 2 of diabetes mellitus at Sanjiwani Gianyar hospital year of 2018-2019. International Journal of Health & Medical Sciences, 4(1), 50-55. https://doi.org/10.31295/ijhms.v4n1.726

Sharma K ,Eltayeb Bo,Mc Gown Ta ,Dunn Sr,Alzahabi B , Rohde R ,Ziyadeh Fn,Lewis Ej Captopril-Induced Reduction Of Serum Levels Of Transforming Growth Factor –Beta 1 Correlates With Long –Term Renoprotection In Insulin Dependent Diabetic Patients .American Journal Of Kidney Disease 1999.34;818-823.

Silvia Marti Alamo ,Yoland Jimenez Sarrion Perez Assistant Professor Doctor, Department Of Stomatology ,Medicine And Dentistry Faculty Valencia University

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864

Urszula J Lopuszanska ‘Katarzynadzlduszko, Krystyna Luda –Zatwarnleka Marta Makera-Studzlnska Department Of Applied Psychology ,Medical University Lubin Poland

Zubin Punthakee ,Et Al (2018) Diabetes Canada Clinical Practice Guidelines Expert Committee Zubin Punthakee Md ,M.Sc Frcpc Ronald Goldenberg Md Frcpc Face Pamela Kartz Md.

Published

14-08-2022

How to Cite

Gopal, K. ., Singh, P., Parate, A. S., Shukla, D., Agrawal, N., & Laskar, P. (2022). Study of biochemical parameters with insulin resistance type 2 diabetes mellitus subjects. International Journal of Health Sciences, 6(S5), 8550–8558. https://doi.org/10.53730/ijhs.v6nS5.10631

Issue

Vol. 6 No. S5 (2022)

Section

Peer Review Articles
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