Sensitivity and specificity of rapid antibody diagnostic test for diagnosis COVID 19 in pediatric patients

Rifah Zafarani Soumena; Retno Asih Setyoningrum

doi:10.53730/ijhs.v6nS6.10573

Authors

Rifah Zafarani Soumena
rifahzafarani@gmail.com
Department of Child Health, Dr. Soetomo Hospital, Airlangga University, Surabaya, East Java, Indonesia
Retno Asih Setyoningrum Department of Child Health, Dr. Soetomo Hospital, Airlangga University, Surabaya, East Java, Indonesia

Keywords:

COVID-19, SARS-CoV2 infection, SARS-CoV-2 testing, COVID-19 antibody testing, COVID-19 serological testing

Abstract

Objective: Aim of this observational is to evaluate the sensitivity and specificity a rapid diagnostic test for COVID-19 for screening COVID-19 pediatric patients. Study Design: 179 Patients under 18 years old with a history of COVID-19 symptoms, and who underwent PCR and/or reference antibody testing for COVID-19. Results: The sampel of this study consisted of 179 patient who 100 sunject with reactive in rapid antibody diagnostic test COVID 19 which consisting of 40 subject positive SARS-CoV2 PCR swab examination and 60 subject negative SARS-CoV2 PCR swab examination. The patient with nonreactive result in rapid antibody diagnostic test COVID 19 which consisting of 19 subject positive SARS-CoV2 PCR swab examination and 60 subject negative SARS-CoV2 PCR swab examination. The sensitivity of the test was 67%. Specificity was 50%. There was substantial agreement between SARS-CoV2 PCR results and a rapid antibody diagnostic test COVID 19. Conclusion: The current evaluation of antibody-based system shows low sensitivity and low specificity result.

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References

Arnawa, I.K., Sapanca, P.L.Y., Martini, L.K.B., Udayana, I.G.B., Suryasa, W. (2019). Food security program towards community food consumption. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1198-1210.

Boulad, F., Kamboj, M., & Bouvier, N. (2020). Covid-19 in children with cancer in New York City. Jama Oncol. 6(9):145-1460.10.1001/jamaoncol.2020.2028

Fujigaki, H., Takemura, M., Osawa, M., Sakurai, A., Nakamoto, K., Setod ,K., Fujita, T., Hata, T., Akimaya, H., Doi, Y., & Saito, K. (2020). Reliability of serological tests for COVID-19: Comparison of three immunochromatography test kits for SARS-CoV-2 antibodies. Heliyon. 6(9):1-6.10.1016/j.heliyon.2020.e04929

Jia, X., Zhang, P., Tian, Y., Wang, J., Zeng, H., Wang, J., Liu, J., Cheng, Z., Zhang, L., He, H., He, K., & Liu, Y. (2021). Clinical significance of IgM and IgG test for diagnosis of highly suspected COVID-19 infection. Frontiers in Medicine. 8:1-8.10.3389/fmed.2021.569266

Lee, K. Y., Rhim, J. W., & Kang, J. H. (2020). Immunopathogenesis of COVID-19 and early immunomodulators. Korean J. Pediatr. 63(7)239-50.10.3345/cep.2020.00759

Lu, H., Stratton, C. W., & Tang, Y. W. (2020). Outbreak of pneumonia of unknown etiology in Wuhan China: the mystery and the miracle. Journal of Medical Virology. 92:401-402.10.1002/jmv.25678

Luo, L., Liu, D., Liao, X., Wu, X., Jing, Q. L., Zheng, J. Z., Liu, F. H., Yang, S. G., Bi, B., Li, Z. H., Liu, J. P., Song, W. Q., Zhu, W., Wang, Z., Zhang, X., Chen, P., Liu, H. M., Cheng, X., Cai, M. C., Huang, Q. M., Yang, P., Yang, X, F., Han, Z. G., Tang, J. L., Ma, Y., & Mao, C. (2020). Contact and risk of transmission in 3410 close contacts of patients with COVID-19 in Guangzhou, China : Prospective Cohort Study. Annals of Internal Medicine. 1-22. https://doi.org/10.7326/M20-2671

Maggi, E., Canonica, G. W., & Moretta, L. (2020). COVID-19: Unanswered questions on immune response and pathogenesis. The Journal of Allergy and Clinical Immunology. 146(1):18-22. https://doi.org/10.1016/j.jaci.2020.05.001

Miller, T. E., Beltran, W. F., Bard, A. Z., Gogakos, T., Anahtar, M. N., Astudillo, M. G., Yang, D., Thierauf, J., Fisch, A. S., Mahowald, G. K., Fitzpatrick, M. J., Nardi, V., Feldman, J., Hauser, B. M., Caradonna, T. M., Marble H. D., Ritterhouse, L. L., Turbett, S. E., & Batten, J. (2020). Clinical sensitivity and interpretation of PCR and serological COVID-19 diagnostics for patients presenting to the hospital. The Faseb Journal. 30:13877-13884. 10.1096/fj.202001700RR

Montesinos, I., Gruson, D., Kabamba, B., Dahma, H., Van Wijngaert, S., Reza, S., Carbone, O. V., Gulbis, B., Wolff, F., Villalobos, R. H. (2020). Evaluation of two automated and three rapid lateral flow immunoassays for the detection of anti-SARS-CoV-2 antibodies. Journal of Clinical Virology. 128:1-6.10.1016/j.jcv.2020.104413

Qiu, H., Wu, J., Hong, L., Luo, Y., Song, Q., & Chen, D. (2020). Clinical and epidemiological features of 36 children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study. The Lancet Infectious Disease. 20(6):689-96.10.1016/S1473-3099(20)30198-5

Shen, K., Yang, Y., Wang, T., Zhao, D., Jiang, Y., Jin, R., Zheng, Y., Xu, B., Xie, Z., Lin, L., Shang, Y., Lu, X., Shu, S., Bai, Y., Deng, J., Lu, M., Ye, L., Wang, X., Wang Y., & Gao, L. (2020). Diagnosis, treatment, and prevention of 2019 novel coronavirus infection in children: experts’ consensus statement. World Journal of Pediatrics. 16(3):1-8.10.1007/s12519-020-00343-7

Widana, I.K., Sumetri, N.W., Sutapa, I.K., Suryasa, W. (2021). Anthropometric measures for better cardiovascular and musculoskeletal health. Computer Applications in Engineering Education, 29(3), 550–561. https://doi.org/10.1002/cae.22202

Yonker, Neilan, Yannic B, Ankit B, James R, Puneeta A. (2020). Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses. The Journal of Pediatrics. 227:45-52. 10.1016/j.jpeds.2020.08.037