Curcumim in management of diabetic foot ulcer
A review
Keywords:
curcumim, demethoxy curcumin, diabetic foot ulcers, turmeric, supplementAbstract
Diabetic foot ulcers termed as DFUs or commonly known as diabetic injuries have become the significant reasons for mortality in patients who are suffering from diabetes. Curcumin, a polyphenol is the main curcuminoid present in turmeric (belonging to ginger family Zingiberaceae). It is largely utilized as a dietary, nutritional, herbal supplement, cosmetics element, shading specialist and coloring agent. Curcumin has intense calming, hostile, anti oxidant, anti-inflammatory, antimutagenic, anticancer properties and features making it a commendable possibility for wound healing and other fiery sicknesses. It has been utilized worldwide in miscellaneous forms for manifold health benefits and has gathered noteworthy consideration in the beyond couple of time in treating diabetes and its complexities. Notwithstanding, not many examinations are accessible comparable to curcumin as a diabetic injury mending specialist with the fundamental components still in obscurity. Consequently, this paper examines the potential purposes of this potent natural compound curcumin for the treatment of DFUs with the comparing systems at various points of diabetic injury recuperating. The present audit likewise sums up the different in vitro and in vivo investigations laid out/provided details pertaining to curcumin in treating DFUs. It provide a concise summary of the plethora of research regarding role of curcumin.
Downloads
References
Aggarwal, B. B., Kumar, A., & Bharti, A. C. (2003). Anticancer potential of curcumin: preclinical and clinical studies. Anticancer research, 23(1/A), 363-398. https://pubmed.ncbi.nlm.nih.gov/12680238/
Ak, T., & Gülçin, İ. (2008). Antioxidant and radical scavenging properties of curcumin. Chemico-biological interactions, 174(1), 27-37. https://doi.org/10.1016/j.cbi.2008.05.003
Akbik, D., Ghadiri, M., Chrzanowski, W., & Rohanizadeh, R. (2014). Curcumin as a wound healing agent. Life sciences, 116(1), 1-7. https://doi.org/10.1016/j.lfs.2014.08.016
Allen Jr, R. J., Soares, M. A., Haberman, I. D., Szpalski, C., Schachar, J., Lin, C. D., ... & Warren, S. M. (2014). Combination therapy accelerates diabetic wound closure. PloS one, 9(3), e92667. https://doi.org/10.1371/journal.pone.0092667
Apelqvist, J., Ragnarson-Tennvall, G., Larsson, J., & Persson, U. (1995). Long-term costs for foot ulcers in diabetic patients in a multidisciplinary setting. Foot & ankle international, 16(7), 388-394. https://doi.org/10.1177%2F107110079501600702
Balasubramanian, K. (2006). Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease. Journal of agricultural and food chemistry, 54(10), 3512-3520. https://doi.org/10.1021/jf0603533
Brem, H., Sheehan, P., & Boulton, A. J. (2004). Protocol for treatment of diabetic foot ulcers. The American journal of surgery, 187(5), S1-S10. https://doi.org/10.1016/S0002-9610(03)00299-X
Chand, D., de Lannoy, L., Tucker, R., & Lovejoy, D. A. (2013). Origin of chordate peptides by horizontal protozoan gene transfer in early metazoans and protists: evolution of the teneurin C-terminal associated peptides (TCAP). General and comparative endocrinology, 188, 144-150. https://doi.org/10.1016/j.ygcen.2013.02.006
Falanga, V. (2005). Wound healing and its impairment in the diabetic foot. The Lancet, 366(9498), 1736-1743. https://doi.org/10.1016/S0140-6736(05)67700-8
Irving, G. R., Karmokar, A., Berry, D. P., Brown, K., & Steward, W. P. (2011). Curcumin: the potential for efficacy in gastrointestinal diseases. Best practice & research Clinical gastroenterology, 25(4-5), 519-534. https://doi.org/10.1016/j.bpg.2011.09.005
Karri, V. V. S. R., Gowthamarajan, K., Satish Kumar, M., & Rajkumar, M. (2015). Multiple biological actions of curcumin in the management of diabetic foot ulcer complications: a systematic review. Trop Med Surg, 3(179), 2. http://dx.doi.org/10.4172/2329-9088.1000179
Liang, G., Yang, S., Zhou, H., Shao, L., Huang, K., Xiao, J., ... & Li, X. (2009). Synthesis, crystal structure and anti-inflammatory properties of curcumin analogues. European journal of medicinal chemistry, 44(2), 915-919. https://doi.org/10.1016/j.ejmech.2008.01.031
Mahardika, I. M. R., Suyasa, I. G. P. D., Kamaryati, N. P., & Wulandari, S. K. (2021). Health literacy is strongest determinant on self-monitoring blood glucose (SMBG) type 2 DM patients during COVID-19 pandemic at public health centre in Tabanan Regency. International Journal of Health & Medical Sciences, 4(3), 288-297. https://doi.org/10.31295/ijhms.v4n3.1752
Meng, B., Li, J., & Cao, H. (2013). Antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. Current pharmaceutical design, 19(11), 2101-2113. https://doi.org/10.2174/138161213805289318
Moura, L. I., Dias, A. M., Carvalho, E., & de Sousa, H. C. (2013). Recent advances on the development of wound dressings for diabetic foot ulcer treatment—A review. Acta biomaterialia, 9(7), 7093-7114. https://doi.org/10.1016/j.actbio.2013.03.033
Mun, S. H., Joung, D. K., Kim, Y. S., Kang, O. H., Kim, S. B., Seo, Y. S., ... & Kwon, D. Y. (2013). Synergistic antibacterial effect of curcumin against methicillin-resistant Staphylococcus aureus. Phytomedicine, 20(8-9), 714-718. https://doi.org/10.1016/j.phymed.2013.02.006
Palve, Y. P., & Nayak, P. L. (2012). Curcumin: a wonder anticancer drug. International Journal of Pharmacy and Biomedical Sciences, 3(2), 60-69. https://www.cabdirect.org/globalhealth/abstract/20133008823
Priyadarsini, K. I., Maity, D. K., Naik, G. H., Kumar, M. S., Unnikrishnan, M. K., Satav, J. G., & Mohan, H. (2003). Role of phenolic OH and methylene hydrogen on the free radical reactions and antioxidant activity of curcumin. Free Radical Biology and Medicine, 35(5), 475-484. https://doi.org/10.1016/S0891-5849(03)00325-3
Radhakrishna, K., VVS NRK, B. M., & Kuppusamy, G. (2014). Potential use of herbal medicines in the treatment of diabetic foot ulcers. History, 14(56), 34-42. http://www.discoveryjournals.org/medicalscience/current_issue/v14-15/n54-62/A6.pdf
Ratnawati, I. G. A. A., Suandayani, N. K. T., & Sutapa, G. N. (2019). The linearity of x-ray devices radiation output and its relationship with patient thickness. International Journal of Physical Sciences and Engineering, 3(3), 1–6. https://doi.org/10.29332/ijpse.v3n3.351
Singh, N., Armstrong, D. G., & Lipsky, B. A. (2005). Preventing foot ulcers in patients with diabetes. Jama, 293(2), 217-228. https://doi:10.1001/jama.293.2.217
Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Health and treatment of diabetes mellitus. International Journal of Health Sciences, 5(1), i-v. https://doi.org/10.53730/ijhs.v5n1.2864
WHO. (2014). 10 Facts about Diabetes. https://www.who.int/health-topics/diabetes#tab=tab_1
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
![Creative Commons License](http://i.creativecommons.org/l/by-nc-nd/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.