Comparative evaluation of efficacy of subgingivally delivered simvastatin and placebo gel in the treatment of stage ii periodontitis as an adjunct to scaling and root planing and its effect on porphyromonas gingivalis : A clinico-microbiological study

Vedika Halan; Sneh Agrawal; Varsha Rathod; Palak Dwivedi; Aishwarya Kubal; Anirudh Rao

doi:10.53730/ijhs.v6nS5.11365

Authors

Vedika Halan
drvedikahalan22@gmail.com
M.D.S. Periodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India
Sneh Agrawal Associate Professor, Dept. of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India
Varsha Rathod Professor & H.O.D, Dept. of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India
Palak Dwivedi M.D.S Periodontics, Dept. of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India
Aishwarya Kubal M.D.S Periodontics, Dept. of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India
Anirudh Rao PG student, Dept. of Periodontology, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, C.B.D. Belpada, Sector 7, Navi Mumbai, 400614, Maharashtra, India

Keywords:

simvastatin, placebo gel, porphyromonas gingivalis

Abstract

Aim: To evaluate the clinical efficacy of subgingivally delivered SMV and Placebo gel and compare in the treatment of stage II periodontitis when used as an adjunct to SRP and their antimicrobial effect on the Porphyromonas gingivalis bacteria. Materials & Methods: In a split mouth study design, 10 systemically healthy patients with stage II periodontitis were included in this study based on the inclusion and exclusion criteria. Two sites with deepest pockets were selected. Plaque samples were collected from these pockets at baseline followed by full mouth scaling and root planning, In Group I 1,2% SMV gel and in Group II Placebo gel was placed in the subgingival pockets. Microbiological analysis for Colony Forming Units of P.g was done at baseline after 3 months, Clinical parameters (GI, PI, PD, CAL, mSBI) were evaluated at baseline (before SRP), 1 month and 3 months. Result: Both the groups showed significant reduction in GI, PI, PD, CAL, mSBI and CFU of Pg but Group I showed more significant reduction than Group II.

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