Antibacterial activity and cytotoxic effect of bisphosphonate conjugated gold nanoparticle synthesized using cissus quadrangularis extract

https://doi.org/10.53730/ijhs.v6nS6.11561

Authors

  • Sruthi Harikrishnan Department of Orthodontics and Dentofacial Orthopaedics, Saveetha dental college and Hospital, Saveetha Institute of Medical and Technical sciences (SIMATS), Saveetha University, Chennai-77
  • Navaneethan R. Reader, Department of Orthodontics and Dentofacial Orthopaedics, Saveetha dental college and Hospital, Saveetha Institute of Medical and Technical sciences (SIMATS), Saveetha University, Chennai-77
  • Rajeshkumar S. Associate professor, Department of Pharmacology, Saveetha dental college and Hospital, Saveetha Institute of Medical and Technical sciences (SIMATS), Saveetha University, Chennai-77

Keywords:

bisphosphonate, green synthesis, gold nanoparticles

Abstract

Nanoparticles are being widely used in the field of medicine called Nanomedicine. Biological membranes in the human body are selectively permeable to Nanoparticles. The nanoparticles can be surface modified to attach a variety of ligands which enable them to be biosensors, molecular-scale fluorescent tags, imaging agents, and targeted drug delivery vehicles. Green synthesis of nanoparticles is a type of bottom-up approach in which reaction occurs with the help of reducing and stabilizing agents. Bisphosphonates are increasingly being used to treat a wide range of skeletal issues, including hereditary skeletal disorders in children, cancer-related bone metastases and osteoporosis. Cissus Quadrangularis is a green edible medicinal plant used in Ayurvedic preparations to treat osteoporosis, general inflammatory conditions, ulcers, menstrual disorders, hemorrhoids, and a variety of other ailments. It has been shown to have a variety of pharmacological properties, including antioxidant, antimicrobial, anti-inflammatory, and antiseptic properties. Bisphosphonate conjugated with gold nanoparticle have shown to produce more targeted actionThe purpose of this study was to green synthesize Bisphosphonate conjugated gold nanoparticles with Cissus quadrangularis extract and test their antimicrobial and cytotoxic activity.  

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Published

05-08-2022

How to Cite

Harikrishnan, S., Navaneethan, R., & Rajeshkumar, S. (2022). Antibacterial activity and cytotoxic effect of bisphosphonate conjugated gold nanoparticle synthesized using cissus quadrangularis extract. International Journal of Health Sciences, 6(S6), 3997–4007. https://doi.org/10.53730/ijhs.v6nS6.11561

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Section

Peer Review Articles