Antibacterial activity and cytotoxic effect of bisphosphonate conjugated gold nanoparticle synthesized using asparagus racemosus root extract
Keywords:
bisphosphonate, green synthesis, gold nanoparticlesAbstract
Nanoparticles are being widely used in the field of medicine called Nanomedicine. Biological membranes in the human body are selectively permeable to Nanoparticles. The nanoparticles can be surface modified to attach a variety of ligands which enable them to be biosensors, molecular-scale fluorescent tags, imaging agents, and targeted drug delivery vehicles. Green synthesis of nanoparticles is a type of bottom-up approach in which reaction occurs with the help of reducing and stabilizing agents. Bisphosphonates are increasingly being used to treat a wide range of skeletal issues, including hereditary skeletal disorders in children, cancer-related bone metastases and osteoporosis. Asparagus racemosus is a green edible medical plant used in Ayurvedic preparations to treat aging, vigor, immunity, longevity, and skeletal issues. It has been shown to have a variety of pharmacological properties, including antioxidant, antimicrobial, anti-inflammatory, and antiseptic properties. Bisphosphonate conjugated with gold nanoparticle have shown to produce more targeted action.The goal of this study was to green synthesise Bisphosphonate conjugated gold nanoparticles with asparagus racemosus extract and to check their antimicrobial activity and cytotoxicity. Green synthesis of Bisphosphonate conjugated gold nanoparticles using Asparagus racemosus extract was achieved and is characterized.
Downloads
References
S Rajeshkumar (2016) Green synthesis of different sized antimicrobial silver nanoparticles using different parts of plants – A Review International Journal of ChemTech Research 9 (4) 197-208
Agarwal, H., Kumar, S. V., & Rajeshkumar, S. (2017). A review on green synthesis of zinc oxide nanoparticles–an eco-friendly approach. Resource-Efficient Technologies, 3(4), 406-413. DOI: 10.1016/j.reffit.2017.03.002.
Rajeshkumar S and Bharath L V Mechanism of plant-mediated synthesis of silver nanoparticles - A review on biomolecules involved, characterisation and antibacterial activity Chemico-Biological Interactions 273 (2017) 219-227. http://dx.doi.org/10.1016/j.cbi.2017.06.019.
Santhoshkumar J, Venkat Kumar S Rajeshkumar S, Phyto-assisted synthesis, characterization and applications of gold nanoparticles – A review Biochemistry and Biophysics Reports 11 (2017) 46–57. http://dx.doi.org/10.1016/j.bbrep.2017.06.004.
Menon, S., Rajeshkumar, S., & Kumar, V. (2017). A review on biogenic synthesis of gold nanoparticles, characterization, and its applications. Resource-Efficient Technologies, 3 (4), 516-527. https://doi.org/10.1016/j.reffit.2017.08.002.
Rajeshkumar, S., and Poonam Naik. "Synthesis and biomedical applications of cerium oxide nanoparticles–a review." Biotechnology Reports 17 (2018): 1-5. https://doi.org/10.1016/j.btre.2017.11.008.
Agarwal H, Menon S, Kumar SV, Rajeshkumar S. Mechanistic study on antibacterial action of zinc oxide nanoparticles synthesized using green route. Chemico-biological interactions. (2018), 25;286:60-70. doi: 10.1016/j.cbi.2018.03.008.
Menon, Soumya, Shrudhi Devi KS, R. Santhiya, S. Rajeshkumar, and Venkat Kumar. "Selenium nanoparticles: A potent chemotherapeutic agent and an elucidation of its mechanism." Colloids and Surfaces B: Biointerfaces 170 (2018): 280-292.https://doi.org/10.1016/j.colsurfb.2018.06.006.
Rajeshkumar S, Malarkodi C, Paulkumar K, Vanaja M, Gnanajobitha G, Kannan C, Annadurai G Seaweed mediated synthesis of gold nanoparticles using Turbinaria conoides and its characterization (2013) Journal of Nanostructures in Chemistry 3 (44): 1-7.
S Rajeshkumar, S Venkat Kumar, C Malarkodi, M Vanaja, K Paulkumar, G Annadurai Optimized synthesis of gold nanoparticles using green chemical process and it’s Invitro anticancer activity against HepG2 and A549 cell lines Mechanics, Materials Science & Engineering (2017) Vol 9. doi:10.2412/mmse.95.26.479
Malarkodi C, Rajeshkumar S, Paulkumar K, Gnanajobitha G, Vanaja M, Annadurai Eco-friendly synthesis and characterization of gold nanoparticles using Klebsiella pneumoniae (2013) Journal of Nanostructure in Chemistry 2013, 3:30 doi:10.1186/2193-8865-3-30.
S Rajeshkumar (2016) Anticancer activity of eco-friendly gold nanoparticles against lung and liver cancer cells Journal of Genetic Engineering and Biotechnology (2016) 14, 195–202
Malarkodi C, S Rajeshkumar and G Annadurai Detection of environmentally hazardous pesticide in fruit and vegetable samples using Gold nanoparticles Food control (2017) 1;80:11-18. http://dx.doi.org/10.1016/j.foodcont.2017.04.023
Yasmin A, Ramesh K, Rajeshkumar S Optimization and stabilization of gold nanoparticles by using herbal plant extract with microwave heating (2014) Nanoconvergence 1 (12) 1-7.
M. Ponnanikajamideen, S. Rajeshkumar, M. Vanaja, G. Annadurai In-vivo anti-diabetic and wound healing effect of antioxidant gold nanoparticles synthesized using insulin plant (Chamaecostus cuspidatus) Canadian Journal of Diabetes (2018), 9(8):1204..https://doi.org/10.1016/j.jcjd.2018.05.006
Zhang L, Gu FX, Chan JM, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in Medicine: Therapeutic Applications and Developments [Internet]. Vol. 83, Clinical Pharmacology & Therapeutics. 2008. p. 761–9. Available from: http://dx.doi.org/10.1038/sj.clpt.6100400
States) EO of TPWDC (united, Executive Office of the President, Washington, DC (United States). Bridge to a sustainable future: National environmental technology strategy [Internet]. 1995. Available from: http://dx.doi.org/10.2172/666279
McNeil SE. Nanotechnology for the biologist [Internet]. Vol. 78, Journal of Leukocyte Biology. 2005. p. 585–94. Available from: http://dx.doi.org/10.1189/jlb.0205074
Brannon-Peppas L, Blanchette JO. Nanoparticle and targeted systems for cancer therapy [Internet]. Vol. 56, Advanced Drug Delivery Reviews. 2004. p. 1649–59. Available from: http://dx.doi.org/10.1016/j.addr.2004.02.014
Kawasaki ES, Player A. Nanotechnology, nanomedicine, and the development of new, effective therapies for cancer [Internet]. Vol. 1, Nanomedicine: Nanotechnology, Biology and Medicine. 2005. p. 101–9. Available from: http://dx.doi.org/10.1016/j.nano.2005.03.002
Zhang S. Emerging biological materials through molecular self-assembly. Biotechnol Adv. 2002 Dec;20(5-6):321–39.
Kim BYS, Rutka JT, Chan WCW. Nanomedicine [Internet]. Vol. 363, New England Journal of Medicine. 2010. p. 2434–43. Available from: http://dx.doi.org/10.1056/nejmra0912273
Longmire M, Choyke PL, Kobayashi H. Clearance properties of nano-sized particles and molecules as imaging agents: considerations and caveats. Nanomedicine . 2008 Oct;3(5):703–17.
Chatterjee DK, Fong LS, Zhang Y. Nanoparticles in photodynamic therapy: an emerging paradigm. Adv Drug Deliv Rev. 2008 Dec 14;60(15):1627–37.
Cao G, Wang Y. Nanostructures and Nanomaterials [Internet]. World Scientific Series in Nanoscience and Nanotechnology. 2011. Available from: http://dx.doi.org/10.1142/7885
Gerberich WW, Jungk JM, Mook WM. THE BOTTOM-UP APPROACH TO MATERIALS BY DESIGN [Internet]. Nano and Microstructural Design of Advanced Materials. 2003. p. 211–20. Available from: http://dx.doi.org/10.1016/b978-008044373-7/50046-2
Mohanpuria P, Rana NK, Yadav SK. Biosynthesis of nanoparticles: technological concepts and future applications [Internet]. Vol. 10, Journal of Nanoparticle Research. 2008. p. 507–17. Available from: http://dx.doi.org/10.1007/s11051-007-9275-x
Luechinger NA, Grass RN, Athanassiou EK, Stark WJ. Bottom-up Fabrication of Metal/Metal Nanocomposites from Nanoparticles of Immiscible Metals [Internet]. Vol. 22, Chemistry of Materials. 2010. p. 155–60. Available from: http://dx.doi.org/10.1021/cm902527n
Anastas PT, Warner JC. Green Chemistry: Theory and Practice. Oxford University Press, USA; 2000. 135 p.
Kharissova OV, Rasika Dias HV, Kharisov BI, Pérez BO, Jiménez Pérez VM. The greener synthesis of nanoparticles [Internet]. Vol. 31, Trends in Biotechnology. 2013. p. 240–8. Available from: http://dx.doi.org/10.1016/j.tibtech.2013.01.003
Narayanan KB, Sakthivel N. Green synthesis of biogenic metal nanoparticles by terrestrial and aquatic phototrophic and heterotrophic eukaryotes and biocompatible agents [Internet]. Vol. 169, Advances in Colloid and Interface Science. 2011. p. 59–79. Available from: http://dx.doi.org/10.1016/j.cis.2011.08.004
Fujimura, Y. et al. (2009) ‘Influence of bisphosphonates on orthodontic tooth movement in mice’, The European Journal of Orthodontics, pp. 572–577. doi: 10.1093/ejo/cjp068.
Kale, S. et al. (2004) ‘Comparison of the effects of 1,25 dihydroxycholecalciferol and prostaglandin E2 on orthodontic tooth movement’, American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 125(5), pp. 607–614.
Karras, J. C. et al. (2009) ‘Effect of alendronate on orthodontic tooth movement in rats’, American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 136(6), pp. 843–847.
Keles, A. et al. (2007) ‘Inhibition of tooth movement by osteoprotegerin vs. pamidronate under conditions of constant orthodontic force’, European journal of oral sciences, 115(2), pp. 131–136.
Kim, T. W. et al. (1999) ‘An ultrastructural study of the effects of bisphosphonate administration on osteoclastic bone resorption during relapse of experimentally moved rat molars’, American journal of orthodontics and dentofacial orthopedics: official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 115(6), pp. 645–653.
Licata, A. A. (2005) ‘Discovery, clinical development, and therapeutic uses of bisphosphonates’, The Annals of pharmacotherapy, 39(4), pp. 668–677.
Liu, L. et al. (2004) ‘Effects of local administration of clodronate on orthodontic tooth movement and root resorption in rats’, European journal of orthodontics, 26(5), pp. 469–473.
Marx, R. E. (2003) ‘Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic’, Journal of oral and maxillofacial surgery: official journal of the American Association of Oral and Maxillofacial Surgeons, 61(9), pp. 1115–1117.
Singh M, Manikandan S, Kumaraguru AK. Nanoparticles: A New Technology with Wide Applications [Internet]. Vol. 1, Research Journal of Nanoscience and Nanotechnology. 2011. p. 1–11. Available from: http://dx.doi.org/10.3923/rjnn.2011.1.11
Dykman L, Khlebtsov N. Gold Nanoparticles in Biomedical Applications. CRC Press; 2017. 332 p.
Sul O-J, Ok-Joo SUL, Jin-Chun KIM, Kyung T-W, Hye-Jin KIM, Youn-Young KIM, et al. Gold Nanoparticles Inhibited the Receptor Activator of Nuclear Factor-κB Ligand (RANKL)-Induced Osteoclast Formation by Acting as an Antioxidant [Internet]. Vol. 74, Bioscience, Biotechnology, and Biochemistry. 2010. p. 2209–13. Available from: http://dx.doi.org/10.1271/bbb.100375
Heo DN, Ko W-K, Bae MS, Lee JB, Lee D-W, Byun W, et al. Enhanced bone regeneration with a gold nanoparticle–hydrogel complex [Internet]. Vol. 2, J. Mater. Chem. B. 2014. p. 1584–93. Available from: http://dx.doi.org/10.1039/c3tb21246g
Zhang X-D, Wu, Shen, Liu, Sun, Zhang, et al. Size-dependent in vivo toxicity of PEG-coated gold nanoparticles [Internet]. International Journal of Nanomedicine. 2011. p. 2071. Available from: http://dx.doi.org/10.2147/ijn.s21657
Khanra K, Panja S, Choudhuri I, Chakraborty A, Bhattacharyya N. Bactericidal and Cytotoxic Properties of Silver Nanoparticle Synthesized from Root Extract of Asparagus Racemosus [Internet]. Vol. 8, Nano Biomedicine and Engineering. 2016. Available from: http://dx.doi.org/10.5101/nbe.v8i1.p39-46
Pallela PNVK, Pallela PNV, Ummey S, Ruddaraju LK, Kollu P, Khan S, et al. Antibacterial activity assessment and characterization of green synthesized CuO nano rods using Asparagus racemosus roots extract [Internet]. Vol. 1, SN Applied Sciences. 2019. Available from: http://dx.doi.org/10.1007/s42452-019-0449-9
Raut RW. Rapid Biosynthesis Of Platinum And Palladium Metal Nanoparticles Using Root Extract Of Asparagus Racemosus Linn [Internet]. Vol. 4, Advanced Materials Letters. 2013. p. 650–4. Available from: http://dx.doi.org/10.5185/amlett.2012.11470
Asparagus racemosus: For medicinal uses & pharmacological actions [Internet]. [cited 2021 Apr17].Availablefrom:https://paperpile.com/app/p/7a78a9a8-daa9-0c80-99f2-fdd0538b5ded
Lateef A, Adelere IA, Gueguim-Kana EB, Asafa TB, Beukes LS. Green synthesis of silver nanoparticles using keratinase obtained from a strain of Bacillus safensis LAU 13 [Internet]. Vol. 5, International Nano Letters. 2015. p. 29–35. Available from: http://dx.doi.org/10.1007/s40089-014-0133-4.
42.Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: An Emerging Discipline Evolving from Studies of Ultrafine Particles [Internet]. Vol. 113, Environmental Health Perspectives. 2005. p. 823–39. Available from: http://dx.doi.org/10.1289/ehp.7339
Arnawa, I.K., Sapanca, P.L.Y., Martini, L.K.B., Udayana, I.G.B., Suryasa, W. (2019). Food security program towards community food consumption. Journal of Advanced Research in Dynamical and Control Systems, 11(2), 1198-1210.
Widyaningrum , I. ., Wibisono, N. ., & Kusumawati, A. H. . (2020). Effect of extraction method on antimicrobial activity against staphylococcus aureus of tapak liman (elephantopus scaber l.) leaves. International Journal of Health & Medical Sciences, 3(1), 105-110. https://doi.org/10.31295/ijhms.v3n1.181
Published
How to Cite
Issue
Section
Copyright (c) 2022 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.
