Comparison of doses of paracetamol or ibuprofen to inhibit the formation of biofilms Pseudomonas aeruginosa bacteria
Keywords:
Biofilm, Paracetamol, Ibuprofen, Pseudomonas aeruginosaAbstract
Background: Some antimicrobials are not effective for bacterial therapy Multiple drug resistance and that form biofilms so strategies of looking for alternative therapies began to be developed. Paracetamol and ibuprofen as non-antibiotic drugs that have the potential to inhibit the formation of biofilms. In this study, a trial was carried out comparing exposure to doses of paracetamol and ibuprofen to inhibit the formation of biofilms of clinical isolates stored Pseudomonas aeruginosa. Method: This study is a true experimental study. Results: The results of the study obtained paracetamol and ibuprofen were able to inhibit the formation of biofilms. A dose of paracetamol 1000mg is able to inhibit the formation of Pseudomonas aeruginosa biofilm up to 68.15%. A dose of ibuprofen 800mg is able to inhibit up to 49.13%. The results of statistical tests comparing doses capable of inhibiting, paracetamol and ibuprofen showed significant differences for all doses, except ibuprofen doses of 600mg and 800mg were not obtained significantly different from p=0.422 values. Conclusion: Paracetamol and ibuprofen are able to inhibit the formation of biofilm of Pseudomonas aeruginosa bacteria with concentration-dependent activity through optical density value measurement tests using ELISA reader.
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