Understanding cell to cell communication in tumor microenvironment: Translating the present knowledge to therapeutics

Akshita Gupta; Pallavi Sati; Kirtish Acharya; Hitesh Shingadia; Anto Simon M. Joseph; Ravindran Jaganathan; Supriyo Mukherjee

doi:10.53730/ijhs.v6nS6.12539

Authors

Akshita Gupta
24akshitagupta@gmail.com
Department of Microbiology, University of Nirwan
Pallavi Sati High Altitude Plant Physiology, Research Center Hemwati Nandan,Bahuguna Garhwal University, Srinagar
Kirtish Acharya Department of Physiology, MKCG Medical College, Berhampur University
Hitesh Shingadia Department of Zoology,SVKM’S Mithibai College of Arts, Chauhan Institute of Science and Amrutben Jivanlal College of Commerce and Ecnomics,University of Mumbai
Anto Simon Joseph M. Research Scholar,Department of Biotechnology,Sri Krishna Arts and Science College, Coimbatore
Ravindran Jaganathan Microbiology Unit, Preclinical Department, Royal college of Medicine Perak, Universiti Kuala Lumpur
Supriyo Mukherjee Department of Microbiology, University of Kalyani

Keywords:

tumor microenvironment, cell-to-cell communication, cell signaling, carcinogenesis, cancer therapy

Abstract

The tumor microenvironment is an atmosphere that covers a tumor withinside the body. It consists of the extracellular matrix, immune cells, blood vessels, and different cells, like fibroblasts. Cell-to-cell communication is a vital procedure that continues the organic features and hemostasis of cells in microenvironmental, organs, and intact systems. The cell-to-cell communication complexity has been studied for many years and is now well-known because a part of the molecular mechanisms of complexity, organ disorder, and developmental biology. A tissue microenvironment of a growing tumor is constituted of the tumor stroma, proliferating tumor cells, infiltrating inflammatory cells, blood vessels, and quite a few related tissue cells. The tumor microenvironment offers all the vitamins, it desires to the tumor and also makes an area for the tumor to expand. Researchers are running to recognize its position in most cancer risk, improvement, and treatment. While therapeutically focused on the tumor microenvironment is an appealing method for the remedy of most cancers, current FDA-permitted remedies have restrained efficacy. Immune checkpoint blockade remedy changed into the primary era of antibody-primarily based cures to target immune cells withinside the microenvironment of tumor (PD1 and CTLA4).

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References

AlMusawi, S., Ahmed, M., & Nateri, A. S. (2021). Understanding cell‐cell communication and signaling in the colorectal cancer microenvironment. Clinical and Translational Medicine, 11(2), e308.

Alnagmy, A., Zaghloul, M. S., Mahmoud, M., Aboelkasem, H., Mokhtar, M. H., & Awad, A. (2022). Dosimetric comparison between intensity modulated radiotherapy and three-dimensional conformal radiotherapy in adjuvant setting after radical cystectomy in high-risk urothelial bladder cancer . International Journal of Health Sciences, 6(S6), 7366–7375. https://doi.org/10.53730/ijhs.v6nS6.11819

Ancey, P. B., Contat, C., & Meylan, E. (2018). Glucose transporters in cancer–from tumor cells to the tumor microenvironment. The FEBS journal, 285(16), 2926-2943.

Baghban, R., Roshangar, L., Jahanban-Esfahlan, R., Seidi, K., Ebrahimi-Kalan, A., Jaymand, M., & Zare, P. (2020). Tumor microenvironment complexity and therapeutic implications at a glance. Cell Communication and Signaling, 18(1), 1-19.

Barari, A. (2021). Targeted Combination Treatment in Renal Cell Carcinoma (Doctoral dissertation, Wayne State University).

Bassler, B. L. (2002). Small talk: cell-to-cell communication in bacteria. Cell, 109(4), 421-424.

Bhalla, U. S., & Iyengar, R. (1999). Emergent properties of networks of biological signaling pathways. Science, 283(5400), 381-387.

Block, K. I., Gyllenhaal, C., Lowe, L., Amedei, A., Amin, A. R., Amin, A., & Sidransky, D. (2015, December). Designing a broad-spectrum integrative approach for cancer prevention and treatment. In Seminars in cancer biology (Vol. 35, pp. S276-S304). Academic Press.

Briscoe, J., & Thérond, P. P. (2013). The mechanisms of Hedgehog signalling and its roles in development and disease. Nature reviews Molecular cell biology, 14(7), 416-429.

Brücher, B. L., & Jamall, I. S. (2014). Cell-cell communication in the tumor microenvironment, carcinogenesis, and anticancer treatment. Cellular Physiology and Biochemistry, 34(2), 213-243.

Cambi, A., de Lange, F., van Maarseveen, N. M., Nijhuis, M., Joosten, B., van Dijk, E. M., & Figdor, C. G. (2004). Microdomains of the C-type lectin DC-SIGN are portals for virus entry into dendritic cells. The Journal of cell biology, 164(1), 145-155.

Castells, M., Thibault, B., Delord, J. P., & Couderc, B. (2012). Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. International journal of molecular sciences, 13(8), 9545-9571.

Danhier, F., Feron, O., & Préat, V. (2010). To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. Journal of controlled release, 148(2), 135-146.

Davis, T. C., Williams, M. V., Marin, E., Parker, R. M., & Glass, J. (2002). Health literacy and cancer communication. CA: a cancer journal for clinicians, 52(3), 134-149.

Dominiak, A., Chełstowska, B., Olejarz, W., & Nowicka, G. (2020). Communication in the cancer microenvironment as a target for therapeutic interventions. Cancers, 12(5), 1232.

Ebbesen, P., Pettersen, E. O., Gorr, T. A., Jobst, G., Williams, K., Kieninger, J., & Scozzafava, A. (2009). Taking advantage of tumor cell adaptations to hypoxia for developing new tumor markers and treatment strategies. Journal of enzyme inhibition and medicinal chemistry, 24(sup1), 1-39.

Espinosa-Rivero, J., Bañuelos, C., & Betanzos, A. (2022). Impact of cell–cell interactions on communication and collectiveness. In Cell Movement in Health and Disease (pp. 51-65). Academic Press.

Fane, M., & Weeraratna, A. T. (2020). How the ageing microenvironment influences tumour progression. Nature Reviews Cancer, 20(2), 89-106.

Fantl, W. J., Johnson, D. E., & Williams, L. T. (1993). Signalling by receptor tyrosine kinases. Annual review of biochemistry, 62(1), 453-481.

Filomeni, G., Rotilio, G., & Ciriolo, M. R. (2002). Cell signalling and the glutathione redox system. Biochemical pharmacology, 64(5-6), 1057-1064.

Franco, P. I. R., Rodrigues, A. P., de Menezes, L. B., & Miguel, M. P. (2020). Tumor microenvironment components: Allies of cancer progression. Pathology-Research and Practice, 216(1), 152729.

Goel, S., Duda, D. G., Xu, L., Munn, L. L., Boucher, Y., Fukumura, D., & Jain, R. K. (2011). Normalization of the vasculature for treatment of cancer and other diseases. Physiological reviews, 91(3), 1071-1121.

Hanahan, D., & Coussens, L. M. (2012). Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer cell, 21(3), 309-322.

Hervé, J. C., & Derangeon, M. (2013). Gap-junction-mediated cell-to-cell communication. Cell and tissue research, 352(1), 21-31.

Jurj, A., Zanoaga, O., Braicu, C., Lazar, V., Tomuleasa, C., Irimie, A., & Berindan-Neagoe, I. (2020). A comprehensive picture of extracellular vesicles and their contents. Molecular transfer to cancer cells. Cancers, 12(2), 298.

Kim, B. S., Das, S., Jang, J., & Cho, D. W. (2020). Decellularized extracellular matrix-based bioinks for engineering tissue-and organ-specific microenvironments. Chemical Reviews, 120(19), 10608-10661.

Kirberger, M. (2011). Defining a Molecular Mechanism for Lead Toxicity via Calcium-Binding Proteins.

Li, I., & Nabet, B. Y. (2019). Exosomes in the tumor microenvironment as mediators of cancer therapy resistance. Molecular cancer, 18(1), 1-10.

Lim, W. A., & Pawson, T. (2010). Phosphotyrosine signaling: evolving a new cellular communication system. Cell, 142(5), 661-667.

Mattes, B., & Scholpp, S. (2018). Emerging role of contact-mediated cell communication in tissue development and diseases. Histochemistry and cell biology, 150(5), 431-442.

Ögmundsdóttir, H. M., Pétursdóttir, I., Gudmundsdóttir, I., Ámundadóttir, L., Rønnov-Jessen, L., & Petersen, O. W. (1993). Effects of lymphocytes and fibroblasts on the growth of human mammary carcinoma cells studied in short-term primary cultures. In Vitro Cellular & Developmental Biology-Animal, 29(12), 936-942.

Pedersen, M. H., Hood, B. L., Beck, H. C., Conrads, T. P., Ditzel, H. J., & Leth-Larsen, R. (2017). Downregulation of antigen presentation-associated pathway proteins is linked to poor outcome in triple-negative breast cancer patient tumors. Oncoimmunology, 6(5), e1305531.

Piferrer, F., Beaumont, A., Falguière, J. C., Flajšhans, M., Haffray, P., & Colombo, L. (2009). Polyploid fish and shellfish: production, biology and applications to aquaculture for performance improvement and genetic containment. Aquaculture, 293(3-4), 125-156.

Schmitz, S., & Machiels, J. P. (2016). Targeting the tumor environment in squamous cell carcinoma of the head and neck. Current treatment options in oncology, 17(7), 1-16.

Siernicka, M., Winiarska, M., Bajor, M., Firczuk, M., Muchowicz, A., Bobrowicz, M., & Zagozdzon, R. (2015). Adenanthin, a new inhibitor of thiol‐dependent antioxidant enzymes, impairs the effector functions of human natural killer cells. Immunology, 146(1), 173-183.

Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2009). Tumor‐associated macrophages (TAM) as major players of the cancer‐related inflammation. Journal of leukocyte biology, 86(5), 1065-1073.

Suryasa, I. W., Rodríguez-Gámez, M., & Koldoris, T. (2021). Get vaccinated when it is your turn and follow the local guidelines. International Journal of Health Sciences, 5(3), x-xv. https://doi.org/10.53730/ijhs.v5n3.2938

Suryatika, I. B. M., Poniman, S., Manuaba, I. B. P., Yasa, I. W. P. S., & Sutapa, G. N. (2021). The potential cancer risk on body organs as abdomen CT-scan exposure result. International Journal of Life Sciences, 5(3), 171–178. https://doi.org/10.53730/ijls.v5n3.1721

Tse, J. C., & Kalluri, R. (2007). Mechanisms of metastasis: epithelial‐to‐mesenchymal transition and contribution of tumor microenvironment. Journal of cellular biochemistry, 101(4), 816-829.

Vail, D. M., Thamm, D. H., & Liptak, J. (2019). Withrow and MacEwen's Small Animal Clinical Oncology-E-Book. Elsevier Health Sciences.

Vlodavsky, I., Bar-Shavit, R., Ishar-Michael, R., Bashkin, P., & Fuks, Z. (1991). Extracellular sequestration and release of fibroblast growth factor: a regulatory mechanism? Trends in biochemical sciences, 16, 268-271.

Weinberg, R. A. (1996). How cancer arises. Scientific American, 275(3), 62-70.

Willert, K., & Nusse, R. (2012). Wnt proteins. Cold Spring Harbor perspectives in biology, 4(9), a007864.

Zheng, D., Liwinski, T., & Elinav, E. (2020). Interaction between microbiota and immunity in health and disease. Cell research, 30(6), 492-506.

Zhou, S., Gravekamp, C., Bermudes, D., & Liu, K. (2018). Tumour-targeting bacteria engineered to fight cancer. Nature Reviews Cancer, 18(12), 727-743.