Genomics in oral cancer

A systematic review

https://doi.org/10.53730/ijhs.v6nS9.12776

Authors

  • Shrikanth Muralidharan Public Health Dentist, Pune, Maharashtra, India
  • Swapna Patankar Assistant Professor, Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune
  • Yashodhara Shah Assistant Professor, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune.
  • Prashant Rao Associate Professor, Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune
  • Prasad Karande Professor and Head of the Department, Department of Oral and Maxillofacial Pathology and Oral Microbiology, DY Patil Dental School, Charoli BK, Lohegaon, Pune

Keywords:

Genomics, Oral Cancer, Biomarkers

Abstract

Background: The genetic factors play an essential role in the cell behavior and function in areas affected with cancer, identifying them could help faster risk detection and mitigation of cases that can be easily saved without much therapeutic intervention at the primary stage itself. This review aims to develop comprehensive evidence regarding genomics in oral cancer initiation, regulation, and progress/inhibition. Material and Methods: A systematic review was carried out of all the reported literature on genomics and proteomics as biomarkers from January 2015 to December 2021 across 3 different search engines- Medline/PubMed, Google Scholar and Scopus. There were 61 articles for the genetic components of oral cancer after following the PRISMA guidelines. Results: Among the 61 articles a number of genes were identified which showed either over or under expression in presence of cancer. All of the proteins showed a rise in their levels in cancer cases compared to healthy cohorts and premalignant cases. The levels of these proteins were also raised significantly in the premalignant cases compared to the healthy patients. Conclusion: A conclusion can be drawn that not all gene markers are raised; some show low expressions.

Downloads

Download data is not yet available.

References

Shah FD, Begum R, Vajaria BN, Patel KR, Patel JB, Shukla SN, et al. A review on salivary genomics and proteomics biomarkers in oral cancer. Indian J Clin Biochem. 2011;26: 326–34.

Public Health England. A report on incidence, survival and mortality rates of oral cancer in England. 2020.

GDC. Mouth cancer cases reach record high GDC publishes 2019 fitness to practise statistics. 2021.

Macpherson LMD. Raising awareness of oral cancer from a public and health professional perspective. Br Dent J. 2018;225: 809–814.

Carvalho K, Sawant P, Dhupar A, Spadigam A. A case of oral squamous cell carcinoma in a nontobacco habitué. Int J Appl Basic Med Res. 2017;7: 278.

Irani S. New insights into oral cancer—Risk factors and prevention: A review of literature. Int J Prev Med. 2020;11: 202.

Quadri MF, Tadakamadla S, John T. Smokeless tobacco and oral cancer in the Middle East and North Africa: A systematic review and meta-analysis. Tob Induc Dis. 2019;17.

Carnielli CM, Macedo CCS, De Rossi T, Granato DC, Rivera C, Domingues RR, et al. Combining discovery and targeted proteomics reveals a prognostic signature in oral cancer. Nat Commun. 2018;9.

Cao Z-H, Cheng J-L, Zhang Y, Bo C-X, Li Y-L. MicroRNA-375 inhibits oral squamous cell carcinoma cell migration and invasion by targeting platelet-derived growth factor-A. Mol Med Rep. 2017;15: 922–928.

Lim HS, Kim CS, Kim JS, Yu SK, Go DS, Lee SA, et al. Suppression of oral carcinoma oncogenic activity by microRNA-203 via down-regulation of SEMA6A. Anticancer Res. 2017;37: 5425–5433.

Fang Z, Zhao J, Xie W, Sun Q, Wang H, Qiao B. LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. Cancer Med. 2017;6: 2897–2908.

Cai Z, Hao X-Y, Liu F-X. MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. Arch Oral Biol. 2018;89: 20–25.

Kawakubo-Yasukochi T, Morioka M, Hazekawa M, Yasukochi A, Nishinakagawa T, Ono K, et al. miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment. Mol Carcinog. 2018;57: 295–302.

Zhang B, Li Y, Hou D, Shi Q, Yang S, Li Q. MicroRNA-375 Inhibits Growth and Enhances Radiosensitivity in Oral Squamous Cell Carcinoma by Targeting Insulin Like Growth Factor 1 Receptor. Cell Physiol Biochem. 2017;42: 2105–2117.

Rastogi B, Kumar A, Raut SK, Panda NK, Rattan V, Joshi N, et al. Downregulation of miR-377 Promotes Oral Squamous Cell Carcinoma Growth and Migration by Targeting HDAC9. Cancer Invest. 2017;35: 152–162.

Zhuang Z, Hu F, Hu J, Wang C, Hou J, Yu Z, et al. MicroRNA-218 promotes cisplatin resistance in oral cancer via the PPP2R5A/Wnt signaling pathway. Oncol Rep. 2017;38: 2051–2061.

Zhuang Z, Xie N, Hu J, Yu P, Wang C, Hu X, et al. Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma. Oncotarget. 2017;8: 21954–21973.

Wang K, Jin J, Ma T, Zhai H. MiR-139-5p inhibits the tumorigenesis and progression of oral squamous carcinoma cells by targeting HOXA9. J Cell Mol Med. 2017;21: 3730–3740.

Sun X, Zhang L. MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2. Biosci Rep. 2017;37.

Moon S, Kim DK, Kim J. Apoptosis-related microRNA-145-5p enhances the effects of pheophorbide a-based photodynamic therapy in oral cancer. Oncotarget. 2017;8: 35184–35192.

Wang T, Ren Y, Liu R, Ma J, Shi Y, Zhang L, et al. miR-195-5p Suppresses the Proliferation, Migration, and Invasion of Oral Squamous Cell Carcinoma by Targeting TRIM14. Biomed Res Int. 2017;2017: 1–13.

Min S-K, Jung SY, Kang HK, Park S-A, Lee JH, Kim M-J, et al. Functional diversity of miR-146a-5p and TRAF6 in normal and oral cancer cells. Int J Oncol. 2017;51: 1541–1552.

Peng C-Y, Liao Y-W, Lu M-Y, Yu C-H, Yu C-C, Chou M-Y. Downregulation of miR-1 enhances tumorigenicity and invasiveness in oral squamous cell carcinomas. J Formos Med Assoc. 2017;116: 782–789.

He B, Lin X, Tian F, Yu W, Qiao B. MiR‐133a‐3p Inhibits Oral Squamous Cell Carcinoma (OSCC) Proliferation and Invasion by Suppressing COL1A1. J Cell Biochem. 2018;119: 338–346.

Shi Y, Bo Z, Pang G, Qu X, Bao W, Yang L, et al. MiR-99a-5p regulates proliferation, migration and invasion abilities of human oral carcinoma cells by targeting NOX4. Neoplasma. 2017;64: 666–673.

Li X, Fan Q, Li J, Song J, Gu Y. MiR-124 down-regulation is critical for cancer associated fibroblasts-enhanced tumor growth of oral carcinoma. Exp Cell Res. 2017;351: 100–108.

Shang A, Lu W-Y, Yang M, Zhou C, Zhang H, Cai Z-X, et al. miR-9 induces cell arrest and apoptosis of oral squamous cell carcinoma via CDK 4/6 pathway. Artif Cells, Nanomedicine, Biotechnol. 2017; 1–9.

Tseng H, Tseng Y, You J, Kang B, Wang T, Yang C, et al. Next-generation Sequencing for microRNA Profiling: MicroRNA-21-3p Promotes Oral Cancer Metastasis. Anticancer Res. 2017;37: 1059–1066.

Peng S-Y, Tu H-F, Yang C-C, Wu C-H, Liu C-J, Chang K-W, et al. miR-134 targets PDCD7 to reduce E-cadherin expression and enhance oral cancer progression. Int J Cancer. 2018;143: 2892–2904.

KIM H, YANG JM, AHN S-H, JEONG W-J, CHUNG J-H, PAIK JH. Potential Oncogenic Role and Prognostic Implication of MicroRNA-155-5p in Oral Squamous Cell Carcinoma. Anticancer Res. 2018;38: 5193–5200.

Li N, Nan C-C, Zhong X-Y, Weng J-Q, Fan H-D, Sun H-P, et al. miR-182-5p Promotes Growth in Oral Squamous Cell Carcinoma by Inhibiting CAMK2N1. Cell Physiol Biochem. 2018;49: 1329–1341.

Lien M-Y, Tsai H-C, Chang A-C, Tsai M-H, Hua C-H, Wang S-W, et al. Chemokine CCL4 Induces Vascular Endothelial Growth Factor C Expression and Lymphangiogenesis by miR-195-3p in Oral Squamous Cell Carcinoma. Front Immunol. 2018;9: 412.

KIM J-S, CHOI DW, KIM CS, YU S-K, KIM H-J, GO D-S, et al. MicroRNA-203 Induces Apoptosis by Targeting Bmi-1 in YD-38 Oral Cancer Cells. Anticancer Res. 2018;38: 3477–3485.

Nagai H, Hasegawa S, Uchida F, Terabe T, Ishibashi Kanno N, Kato K, et al. MicroRNA-205-5p suppresses the invasiveness of oral squamous cell carcinoma by inhibiting TIMP‑2 expression. Int J Oncol. 2018;52: 841–850.

Zheng J, Wang J, Jia Y, Liu T, Duan Y, Liang X, et al. microRNA‐211 promotes proliferation, migration, and invasion ability of oral squamous cell carcinoma cells via targeting the bridging integrator 1 protein. J Cell Biochem. 2019;120: 4644–4653.

Li TK, Yin K, Chen Z, Bao Y, Zhang SX. MiR-214 regulates oral cancer KB cell apoptosis through targeting RASSF5. Genet Mol Res. 2017;16.

Wang Z, Wang J, Chen Z, Wang K, Shi L. MicroRNA-1-3p inhibits the proliferation and migration of oral squamous cell carcinoma cells by targeting DKK1. Biochem Cell Biol. 2018;96: 355–364.

Wang X, Li G. MicroRNA‐16 functions as a tumor‐suppressor gene in oral squamous cell carcinoma by targeting AKT3 and BCL2L2. J Cell Physiol. 2018;233: 9447–9457.

Li X, He J, Shao M, Cui B, Peng F, Li J, et al. Downregulation of miR-218-5p promotes invasion of oral squamous cell carcinoma cells via activation of CD44-ROCK signaling. Biomed Pharmacother. 2018;106: 646–654.

Lv L, Wang Q, Yang Y, Ji H. MicroRNA‑495 targets Notch1 to prohibit cell proliferation and invasion in oral squamous cell carcinoma. Mol Med Rep. 2018;19: 693–702.

Yuan G, Wu H, Du Y, He F. Tumor suppressor role of microRNA‑545 in oral squamous cell carcinoma. Oncol Lett. 2018;17: 2063–2068.

Ningning S, Libo S, Chuanbin W, Haijiang S, Qing Z. MiR-650 regulates the proliferation, migration and invasion of human oral cancer by targeting growth factor independent 1 (Gfi1). Biochimie. 2019;156: 69–78.

Feng X, Luo Q, Wang H, Zhang H, Chen F. MicroRNA‐22 suppresses cell proliferation, migration and invasion in oral squamous cell carcinoma by targeting NLRP3. J Cell Physiol. 2018;233: 6705–6713. 1

Lai Y-H, Liu H, Chiang W-F, Chen T-W, Chu LJ, Yu J-S, et al. MiR-31-5p-ACOX1 Axis Enhances Tumorigenic Fitness in Oral Squamous Cell Carcinoma Via the Promigratory Prostaglandin E2. Theranostics. 2018;8: 486–504.

Wang Q, Lv L, Li Y, Ji H. MicroRNA‑655 suppresses cell proliferation and invasion in oral squamous cell carcinoma by directly targeting metadherin and regulating the PTEN/AKT pathway. Mol Med Rep. 2018;18: 3106–3114.

Lin S-S, Peng C-Y, Liao Y-W, Chou M-Y, Hsieh P-L, Yu C-C. miR-1246 Targets CCNG2 to Enhance Cancer Stemness and Chemoresistance in Oral Carcinomas. Cancers (Basel). 2018;10: 272.

Wei D, Wang W, Shen B, Zhou Y, Yang X, Lu G, et al. MicroRNA‑199a‑5p suppresses migration and invasion in oral squamous cell carcinoma through inhibiting the EMT‑related transcription factor SOX4. Int J Mol Med. 2019;44: 185–195.

Huang C, Song H, Lai L. The role and mechanism of microRNA‑18a‑5p in oral squamous cell carcinoma. Mol Med Rep. 2019;20: 1637–1644.

Mahmood N, Hanif M, Ahmed A, Jamal Q, Mushtaq S, Khan A, et al. Circulating miR-21 as a prognostic and predictive biomarker in oral squamous cell carcinoma. Pakistan J Med Sci. 2019;35: 1408–1412.

Chen Y, Song Y, Yu Y, Cheng W, Tong X. miRNA‑10a promotes cancer cell proliferation in oral squamous cell carcinoma by upregulating GLUT1 and promoting glucose metabolism. Oncol Lett. 2019.

Chen F, Qi S, Zhang X, Wu J, Yang X, Wang R. miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis. Pathol - Res Pract. 2019;215: 660–667.

Kurihara-Shimomura M, Sasahira T, Shimomura H, Nakashima C, Kirita T. The Oncogenic Activity of miR-29b-1-5p Induces the Epithelial-Mesenchymal Transition in Oral Squamous Cell Carcinoma. J Clin Med. 2019;8: 273.

Kao Y-Y, Chou C-H, Yeh L-Y, Chen Y-F, Chang K-W, Liu C-J, et al. MicroRNA miR-31 targets SIRT3 to disrupt mitochondrial activity and increase oxidative stress in oral carcinoma. Cancer Lett. 2019;456: 40–48.

Xie C, Du L-Y, Guo F, Li X, Cheng B. Exosomes derived from microRNA-101-3p-overexpressing human bone marrow mesenchymal stem cells suppress oral cancer cell proliferation, invasion, and migration. Mol Cell Biochem. 2019;458: 11–26.

Shi B, Ma C, Liu G, Guo Y. MiR-106a directly targets LIMK1 to inhibit proliferation and EMT of oral carcinoma cells. Cell Mol Biol Lett. 2019;24: 1.

Chen Y-F, Wei Y-Y, Yang C-C, Liu C-J, Yeh L-Y, Chou C-H, et al. miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. Redox Biol. 2019;22: 101140.

Wang L, Chen W, Zha J, Yan Y, Wei Y, Chen X, et al. miR‑543 acts as a novel oncogene in oral squamous cell carcinoma by targeting CYP3A5. Oncol Rep. 2019;42: 973–990.

Zeng D, Xu H, Ji N, Li J, Zhou M, Dan H, et al. In situ measurement of miR‐138 expression in oral squamous cell carcinoma tissue supports the role of this microRNA as a tumor suppressor. J Oral Pathol Med. 2019;48: 911–918.

Ieong C, Ma J, Lai W. RALBP1 regulates oral cancer cells via Akt and is a novel target of miR‐148a‐3p and miR‐148b‐3p. J Oral Pathol Med. 2019;48: 919–928.

Wu M, Duan Q, Liu X, Zhang P, Fu Y, Zhang Z, et al. MiR-155-5p promotes oral cancer progression by targeting chromatin remodeling gene ARID2. Biomed Pharmacother. 2020;122: 109696.

Jiang L, Lv L, Liu X, Jiang X, Yin Q, Hao Y, et al. MiR-223 promotes oral squamous cell carcinoma proliferation and migration by regulating FBXW7. Cancer Biomarkers. 2019;24: 325–334.

Lu M, Wang C, Chen W, Mao C, Wang J. miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling. DNA Cell Biol. 2018;37: 381–388.

Chen R, Zhang Y, Zhang X. MiR-1254 Functions as a Tumor Suppressor in Oral Squamous Cell Carcinoma by Targeting CD36. Technol Cancer Res Treat. 2019;18: 153303381985944.

Wei D, Shen B, Wang W, Zhou Y, Yang X, Lu G, et al. MicroRNA‑199a‑5p functions as a tumor suppressor in oral squamous cell carcinoma via targeting the IKKβ/NF‑κB signaling pathway. Int J Mol Med. 2019;43: 1585–1596.

Wei Z, Lyu B, Hou D, Liu X. Mir-5100 Mediates Proliferation, Migration and Invasion of Oral Squamous Cell Carcinoma Cells Via Targeting SCAI. J Investig Surg. 2021;34: 834–841.

Sun L, Xu K, Cui J, Yuan D, Zou B, Li J, et al. Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma. Oncol Rep. 2019;42: 1319–1328.

Hsing E-W, Shiah S-G, Peng H-Y, Chen Y-W, Chuu C-P, Hsiao J-R, et al. TNF-α-induced miR-450a mediates TMEM182 expression to promote oral squamous cell carcinoma motility. Ahmad A, editor. PLoS One. 2019;14: e0213463.

Chou S-T, Peng H-Y, Mo K-C, Hsu Y-M, Wu G-H, Hsiao J-R, et al. MicroRNA-486-3p functions as a tumor suppressor in oral cancer by targeting DDR1. J Exp Clin Cancer Res. 2019;38: 281.

He J, Ye W, Kou N, Chen K, Cui B, Zhang X, et al. MicroRNA‐29b‐3p suppresses oral squamous cell carcinoma cell migration and invasion via IL32/AKT signalling pathway. J Cell Mol Med. 2020;24: 841–849.

Kasradze D, Juodzbalys G, Guobis Z, Gervickas A, Cicciù M. Genetic and proteomic biomarkers of head-and-neck cancer: A systematic review. J Cancer Res Ther. 2020;16: 410.

Kondoh N, Ohkura S, Arai M, Hada A, Ishikawa T, Yamazaki Y, et al. Gene expression signatures that can discriminate oral leukoplakia subtypes and squamous cell carcinoma. Oral Oncol. 2007;43: 455–462.

Nguyen HB, Jaehne AK, Jayaprakash N, Semler MW, Hegab S, Yataco AC, et al. Early goal-directed therapy in severe sepsis and septic shock: insights and comparisons to ProCESS, ProMISe, and ARISE. Crit Care. 2016;20: 160.

Hirano C, Nagata M, Noman AA, Kitamura N, Ohnishi M, Ohyama T, et al. Tetraspanin gene expression levels as potential biomarkers for malignancy of gingival squamous cell carcinoma. Int J Cancer. 2009;124: 2911–2916.

Irimie A, Ciocan C, Gulei D, Mehterov N, Atanasov A, Dudea D, et al. Current Insights into Oral Cancer Epigenetics. Int J Mol Sci. 2018;19: 670.

Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, et al. Genetic Associations of 115 Polymorphisms with Cancers of the Upper Aerodigestive Tract across 10 European Countries: The ARCAGE Project. Cancer Res. 2009;69: 2956–2965.

KU K, WAN L, PENG H, TSAI M, TSAI C, TSAI F. Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer. Oral Oncol. 2005;41: 497–502.

Published

16-09-2022

How to Cite

Muralidharan, S., Patankar, S., Shah, Y., Rao, P., & Karande, P. (2022). Genomics in oral cancer: A systematic review. International Journal of Health Sciences, 6(S9), 2025–2037. https://doi.org/10.53730/ijhs.v6nS9.12776

Issue

Vol. 6 No. S9 (2022)

Section

Peer Review Articles
Copyright & Licensing

Copyright (c) 2022 International journal of health sciences

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.

Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.

This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.

Crossref
Scopus
Google Scholar
Europe PMC