Proteomics in oral cancer: A systematic review

Shrikanth Muralidharan; Prashant Rao; Prasad Karande; Shashank Gaikwad; Amod Patankar

doi:10.53730/ijhs.v6nS6.12935

Authors

Shrikanth Muralidharan Public Health Dentist, Pune, Maharashtra, India
Prashant Rao Associate Professor, Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune
Prasad Karande Professor and Head of the Department, Department of Oral and Maxillofacial Pathology and Oral Microbiology, DY Patil Dental School, Charoli BK, Lohegaon, Pune
Shashank Gaikwad Professor, Department of Orthodontics, Bharati Vidyapeeth Dental College and Hospital, Navi Mumbai
Amod Patankar Professor, Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed to be University Dental College and Hospital, Pune

Keywords:

biomarkers, oral cancer, proteomics

Abstract

Background: This review aims to develop comprehensive evidence regarding proteomics in oral cancer initiation, regulation, and progress/inhibition. Material and Methods: A systematic review was carried out of all the reported literature on genomics and proteomics as biomarkers from January 2015 to December 2021 across 3 different search engines- Medline/PubMed, Google Scholar and Scopus. There were 11 articles identified after full test review for protein-based studies of oral cancer after following the PRISMA guidelines. Results: Of the 10 articles maximum of them suggested the role of interleukins (IL-6, 8 and 10) along with TNF-α as salivary protein markers in oral squamous cell carcinoma. All of the proteins showed a rise in their levels in cancer cases compared to healthy cohorts and premalignant cases. The levels of these proteins were also raised significantly in the premalignant cases compared to the healthy patients. Conclusion: A conclusion can be drawn that not all markers are raised; some show low expressions and differ according to type and severity of cancer.

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