Deficiency of vitamin D in patients with chronic liver disease at department of medicine HMC Peshawar a multi center study
Keywords:
deficiency vitamin D, level vitamin D, fibrosis, chronic liver diseaseAbstract
Background: Multiple nutrients are deficient in people with chronic liver disease (CLD), but vitamin D insufficiency is more prevalent in CLD patients than in patients with other deficiencies. As a result of liver fibrosis, the liver's synthetic abilities are diminished, and this compromises activation through a decrease in vitamin D Binding Protein, which results in vitamin D insufficiency. The situation is further complicated by a decline in performance and nutritional deficiencies. The research examined the prevalence of vitamin D insufficiency in people with chronic liver disease and its relationship to the severity of the condition. Methodology: The Multi center study conducted in department of Medicine at the Hayatabad Medical Complex in Peshawar carried out this. 71 CLD patients who satisfied the criteria were included in the research. Three groups of patients were divided based on their Child-Pugh scores. The patient's vitamin D levels were examined by hospital laboratories. Serum (26,OH)D concentrations below 30 nmol/L were considered to represent [vitamin D] insufficiency levels. The data were examined using SPSS version 22. Results: 71 CLD patients were assessed. In this study the (mean age) was 52.43 ± 12.190.years. The (male-to-female ratio) was 02.04:01.
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References
Ahmad, M., Khan, A., & Khan, M. (2017). Association of vitamin D deficiency and chronic liver disease: A systematic review and meta-analysis. PloS one, 12(12), e0189642.
Fisher L, Fisher A. Vitamin D and parathyroid hormone in outpatients with non cholestatic chronic liver disease. Clin Gastroenterol Hepatol. 2007;5(4):513-20.
Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr. 2012;95(1):91-100.
Anty R, Tonohouan M, Ferrari-Panaia P, Piche T, Pariente A, Anstee QM, et al. Low Levels of 25-Hydroxy Vitamin D are Independently Associated with the Risk of Bacterial Infection in Cirrhotic Patients. Clin Transl Gastroenterol. 2014;5(5):e56.
Arteh J, Narra S, Nair S. Prevalence of vitamin D deficiency in chronic liver disease. Dig Dis Sci. 2010;55(9):2624-8.
Heuman DM, Mihas AA, Habib A, Gilles HS, Stravitz RT, Sanyal AJ, et al. MELD-XI: a rational approach to "sickest first" liver transplantation in cirrhotic patients requiring anticoagulant therapy. Liver Transplant. 2007;13(1):30-7.
Stokes CS, Volmer DA, Grünhage F, Lammert F. Vitamin D in chronic liver disease. Liver Int. 2013;33(3):338-52.
Falak S, Aftab L, Saeed M, Islam A. Prevalence of Vitamin-D deficiency is related to the severity of liver damage in Hepatitis-C patients. Pak J Med Sci. 2020;36.
Jamil Z, Arif S, Khan A, Durrani AA, Yaqoob N. Vitamin D Deficiency and Its Relationship with Child-Pugh Class in Patients with Chronic Liver Disease. J Clin Transl Hepatol. 2018;6(2):135-40.
Zhang R, Naughton DP. Vitamin D in health and disease: Current perspectives. Nutr J. 2010;9(1):65.
Konstantakis C, Tselekouni P, Kalafateli M, Triantos C. Vitamin D deficiency in patients with liver cirrhosis. Ann Gastroenterol. 2016;29(3):297-306.
Johnson LK, Hofsø D, Aasheim ET, Tanbo T, Holven KB, Andersen LF, et al. Impact of gender on vitamin D deficiency in morbidly obese patients: a cross-sectional study. Eur J ClinNutr. 2012;66(1):83-90.
Dokmeci, D., Ataseven, H., & Yilmaz, Y. (2016). Vitamin D deficiency in patients with chronic liver disease. World journal of gastroenterology, 22(7), 2414.
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