The impact of misoprostol in inducing labor in patients having intrauterine foetal death
Keywords:
misoprostol, labour, pregnancy, induction, intrauterine foetal deathAbstract
Background: The most detrimental outcome of pregnancy, intrauterine foetal death (IUFD), causes psychological suffering to the expectant mother and the entire family. Objective: The purpose of this study was to evaluate the effectiveness as well as safety of misoprostol for labour induction in IUFD. Methods: The Department of Obstetrics and Gynecology at the MTI-HMC, Peshawar, conducted this clinical research on 120 women who had IUFD from 09 September 2020 to 09 March 2021. With the patient's informed agreement, labour was induced with vaginal misoprostol pills at a dose of 50 mcg four times per day. Results: In research including 120 women, the majority of the women (n=55; 45.83%) were between the ages of 21 and 30, with a median gestational age of 37.61 ± 4.17 weeks. The majority of patients (n=83; 69.17%) did not have appointments, were from rural areas (n=79; 65.83%), and had no formal education (n=91; 75.83%). In our study, 49 women (40.83%) were primigravidas, whereas 71 women (59.17%) were multigravidas. Following misoprostol introduction, the average Bishop's score increased to 6.89 ± 2.3 from 2.32 ± 1.28 at baseline, a difference of 4.57 on average.
Downloads
References
Blanchord K, Winikoff B, Coyaji K, Ngoc NTN. Misoprostol alone – a new method of medical abortion? JAMWA 2000; 55: 189-190
Hofmeyr GJ, Alhrevic Z, Matonhodze B, Brocklehurst P, Campbell E, Nikodem VC. Tibated oral misoprostol solution for induction of labour: a multi-centre randomized trial. Br J Obstet Gynaecol 2001; 108: 952-959
HoffMann RAM, Anthony J, Fawcus S. Oral misoprostol vs. placebo in the management of prelabour rupture of membranes at term. Int J Gynaecol Obstet 2001; 72: 215-221.
Goldberg AB, Wing DA, Induction of labour: the misoprostol controversy. J Midwifery Wom Health 2003; 48: 244-248.
Garry D, Fiqueroa R, Kalish RB, Catalano CJ, Maulik D. Randomized controlled trial of vaginal misoprostol versus dinoprostone vaginal insert for labour induction. J Matern Fetal Neonatal Med 2003; 13: 254-259.
Matonhodze BB, Hofmeyr GJ, Leve J. Labour induction at term- a randomized trial comparing Foley catheter plus titrated oral misoprostol solution, titrated oral misoprostol solution alone and dinoprostone. S Afr Med J 2003; 93: 375- 379.
de Aquino MM, Cecatti JG. Misoprostol versus oxytocin for labour induction at term and postterm pregnancy: randomized controlled trial. Sao Paulo Med J 2003; 121: 102-106.
Makhlouf AM, Al-Hussaini TK, Habib DM, Makarem MH. Second trimester pregnancy termination: comparison of three different methods. J Obstet Gynecol 2003; 23: 407-411.
Nakintu N. A comparative study of vaginal misoprostol and intravenous oxytocin for induction of labour in women with intra-uterine fetal death in Malago hospital, Uganda. Afr Health Sci 2001; 1: 55-59.
Blanchard K, Winikoff B, Ellertson C. Misoprostol used alone for the termination of early pregnancy: a review of the evidence. Contraception 1999; 59: 209-217.
Abdul, M. A., Ibrahim, U. N., Yusuf, M. D., & Musa, H. (2007). Efficacy and safety of misoprostol in induction of labour in a Nigerian tertiary hospital. West African Journal of Medicine, 26(3), 213-216.
Abdul, M. A., Ibrahim, U. N., Yusuf, M. D., & Musa, H. Efficacy and Safety of Misoprostolin Induction of Labourina Nigerian Tertiary Hospital.
Abdul, M. A., Shittu, S. O., Ameh, N., & Khan, T. (2006). Effectiveness of misoprostol in the management of intra-uterine foetal death.
Fawole AO, Adekunle AO, Sotiloye OS, Arowojolu OA, Otolorin EO. Experience with intravaginal misoprostol in the management of intra-uterine fetal death. Tropical Journal of Obstetrics and Gynaecology 2001;18(suppl 1): 35.
Ezechi OC, Njokanma FO, Nwokoro CA, safety and efficacy of misoprostol in induction of labour. Tropical Journal of Obstetrics and Gynaecology 2001; 18(suppl.1): 61
Easmin S, Nahar K, Jahan MK, et al. Intra-vaginal use of misoprostol for induction of labour in intrauterine death. Mymensingh Med J 2011;20(4):566-9
El-Gharib MN, Elebyary MT. Low-dose vaginal misoprostol in the management of intrauterine fetal death. J Matern Fetal Neonate Med 2011;24(10):1239- 42.
Panda S, Jha V, Singh S. Role of combination of mifepristone and misoprostol versus misoprostol alone in induction of labour in late IUFD: a prospective study. J Family Report Health 2013;7(4):177-9.
Chaudhari P, Datta S. Mifepristone and misoprostol compared with misoprostol alone for induction of labour in intrauterine fetal death: a randomized trial. J Obstet Gynaecol Res 2015;41(12):1884-90
Nyende L, Towobola OA, Mabina MH. Comparison of vaginal and oral misoprostol, for the induction of labour in women with intra-uterine foetal death. East Afr Med J 2004;81(4):179-82.
De Heus R, Graziosi GC, Christiaens GC, et al. Medical management for termination of second and third trimester pregnancies: a comparison of strategies. Eur J Obstet Gynecol Reprod Biol 2004;116(1):16-21.
Published
How to Cite
Issue
Section
Copyright (c) 2023 International journal of health sciences
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Articles published in the International Journal of Health Sciences (IJHS) are available under Creative Commons Attribution Non-Commercial No Derivatives Licence (CC BY-NC-ND 4.0). Authors retain copyright in their work and grant IJHS right of first publication under CC BY-NC-ND 4.0. Users have the right to read, download, copy, distribute, print, search, or link to the full texts of articles in this journal, and to use them for any other lawful purpose.
Articles published in IJHS can be copied, communicated and shared in their published form for non-commercial purposes provided full attribution is given to the author and the journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
This copyright notice applies to articles published in IJHS volumes 4 onwards. Please read about the copyright notices for previous volumes under Journal History.