Keloid with intra-lesional steroid injection

Trying a new way

https://doi.org/10.53730/ijhs.v6nS9.13935

Authors

  • Sana Gul Consultant Dermatologist, Jinnah Medical and Dental College, Karachi
  • Shakila Junaid Assistant Professor of Dermatology, PNS Rahat, Karachi
  • Muhammad Kashif Consultant Anesthesiologist, South City Hospital, Karachi
  • Madiha Izhar Assistant Professor Dermatology, Fazaia Ruth Pfau Medical College/ PAF Hospital Masroor, Karachi
  • Nadia Farooq Assistant Professor, Baqai Medical University, Karachi
  • Fatima Zahoor Resident Dermatology, PNS Shifa, Karachi

Keywords:

Keloids, Intralesional steroid injections, Dental syringe

Abstract

Introduction: Keloids are the result of an overgrowth of dense fibrous tissue that usually develops after healing of a skin injury. The exact pathogenesis of Keloids is unknown and their occurrence is spontaneous. The uncontrolled overgrowth of dense fibrous tissue extends beyond the borders of original wound and does not regress. No single therapeutic modality has been proven to be most effective for treatment therefore this study is plan to use intralesional steroids injection in keloid and measure the efficacy and to see if it is a better and cost effective method and also to determine its utility for clinical practice in dermatology in future. Objective: To determine the efficacy of intralesional steroid injections in keloids with dental syringe. Settings: Dermatology department, Jinnah Medical College Hospital in outpatient department (OPD). Duration: 06 months from 14th April’2018 to 14th Oct’ 2018. Design: Cohort Study. Subject and Methods: A total of 79 patients with having keloid were included in this study. During each visit, the size of the keloid was recorded centimeter using the Vernier's calipers, in terms of length, breadth, and height Injection triamcinolone acetonide was used in strength of 40 mg/ml.

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References

Gauglitz GG, Korting HC, Pavicic T, Ruzicka T, Jeschke MG. Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies. Mol Med. 2011;17(1-2):113-25.

Oluwasanmi JO. Keloids in the African. ClinPlast Surg. 1974;1:179–95.

Moustafa MF, Abdel-Fattah MA, Abdel-Fattah DC. Presumptive evidence of the effect of pregnancy estrogens on keloid growth: case report. Plast Reconstr Surg. 1975;56:450–3

Bayat A, et al. Keloid disease: Clinical relevance of single versus multiple site scars. Br J Plast Surg. 2005;58:28–37.

Niessen FB, Spauwen PH, Schalkwijk J, Kon M. On the nature of hypertrophic scars and keloids: a review. PlastReconstr Surg. 1999;104:1435–58.

Khan KA, Muhammad S, Saeed HT. Keloids: Clinical features and management. Part I. J Pak Assoc Dermatol 2006;16:97-103

Granstein RD, Rook A, Flotte TJ. A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Clinical and histologic findings. Arch Dermatol. 1990;126(10):1295-302.

Nanda S, Reddy BS. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Surg. 2004;30:54-6.

Chowdri NA,Darzi MA,Masarat M, Mattoo A,.Keloids and hypertrophic scars: results with intraoperative and serial postoperative corticosteroid injection therapy.Aust N Z J Surg. 1999;69(9):655-9.

Sadeghinia A, Sadeghinia S.Comparison of the efficacy of intralesional triamcinolone acetonide and 5-fluorouracil tattooing for the treatment of keloids. Dermatol Surg. 2012;38(1):104-9.

Davison SP, Dayan JH, Clemens MW, Sonni S, Wang A, Crane A.Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids. AesthetSurg J. 2009;29(1):40-6.

Koc E, Arca E, Surucu B, Kurumlu Z. An open, randomized, controlled, comparative study of the combined effect of intralesional triamcinolone acetonide and onion extract gel and intralesional triamcinolone acetonide alone in the treatment of hypertrophic scars and keloids. Dermatol Surg. 2008;34(11):1507-14.

Lee JH, Kim SE, Lee AY. Effects of interferon-alpha2b on keloid treatment with trimacinoloneacetonide intralesional injection. Int J Dermatol. 2008;47(2):183-6.

Muneuchi G, Suzuki S, Onodera M, Ito O, Hata Y, Igawa HH. long-term outcome of intralesional injection of triamcinolone acetonide for treatment of keloid scars in asian patients. Scand J PlastReconstr Surg Hand Surg. 2006;40(2):111-6.

Prabhu A, H Sreekar,Powar R, VM UppinA randomized controlled trial comparing the efficacy of intralesional 5-fluorouracil versus triamcinolone acetonide in the treatment of keloids. J Scientific Society. 2012; 39:19-25.

Hussain M A, L. Kuruppu, N. Sarhadi.Step-by-step guide of a technique of using dental cartridges for intra-lesional steroid injection to keloids. Eur J PlastSurg. 2011; 34(4): 307-309

Nanda S, Reddy BS. Intralesional 5-fluorouracil as a treatment modality of keloids. Dermatol Surg 2004; 30:54-9.

Darougheh A, Asilian A, Shariati F. Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars. Clin Exp Dermatol 2009;34:219-23

Robles DT, Moore E, Draznin M, Berg D. Keloids: Pathophysiology and management. Dermatol Online J 2007;13:9.

Khan KA, Muhammad S, Saeed HT. Keloids: Clinical features and management. Part II. J Pak Assoc Dermatol 2006;16:162-72.

Wolfram D, Tzankov A, Pulzi P. Hypertrophic scars and keloids- A review of their pathophysiology, risk factor, and therapeutic management. Dermatol Surg. 2009;35:171-81

Darzi MA, Chowdri NA, Kaul SK, Khan M. Evaluation of various methods of treating keloids and hypertrophic scars: A 10-year follow-up study. Br J Plast Surg 1992;45:374-9.

Kill J. Keloids treated with topical injection of triamcinolone acetonide (Kenalog), Immediate and long-term results. Scand J Plast Reconstr Surg 1977;11:169-72.

Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, Stefanaki K, Argyrakos T, Petridis A, et al. Intralesional 5-fluorouracil in the treatment of keloids: An open clinical and histopathologic study. J Am Acad Dermatol.

Published

06-02-2023

How to Cite

Gul, S., Junaid, S., Kashif, M., Izhar, M., Farooq, N., & Zahoor, F. (2023). Keloid with intra-lesional steroid injection: Trying a new way. International Journal of Health Sciences, 6(S9), 4671–4679. https://doi.org/10.53730/ijhs.v6nS9.13935

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