Effectiveness of topical application of 15℅ salicyclic acid and 0.1℅ diphencyprone combined in an ointment form for treatment of plantar warts

https://doi.org/10.53730/ijhs.v7nS1.14366

Authors

  • Mariam Muhammad Sharif Consultant Dermatologist, Memon Medical Institute Hospital, Karachi Pakistan
  • Saba Nasreen Baqai Medical University, Karachi Pakistan
  • Nadia Farooq Dermatology, Baqai Medical University, Karachi Pakistan
  • Madiha Izhar Fazaiya Ruth Pfau Medical College/ PAF Hospital Masroor, Karachi Pakistan
  • Tooba Malik PNS Rahat Hospital Karachi, Assistant Professor of Dermatology BUM&DC, Karachi Pakistan
  • Naseem Amin Dhedhi Razi Alkhidmat Hospital, CBR Town, Islamabad Pakistan

Keywords:

human papillomavirus (HPV), diphencyprone (DPCP)

Abstract

Objective: To determine the Effectiveness of topical application of 15℅ salicyclic acid and 0.1℅ Diphencyprone combined in an ointment form for treatment of plantar warts. Place and Duration: This Descriptive, case series was held in Dermatology outpatient department, Abbasi Shaheed Hospital Karachi. Method: A sample size of 80 patients with plantar warts were included as calculated by exact 95% confidence interval. Results: Total 80 patients of plantar warts were enrolled. 40 (50%) were females and 40 (50%) were males, with mean age of 31 yrs. 65 patients (81.25%) showed positive response to treatment with combined DPCP and salicyclic acid, while remaining 15 (18.75%) had some mild adverse reactions. Conclusion: As Plantar wart is a common problem in all populations therefore more randomized trials should be done on combined chemical treatments for better outcomes.

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References

Boroujeni NH, Handjani F. Cryotherapy versus CO2 laser in the treatment of plantar warts: a randomized controlled trial. Dermatology practical & conceptual. 2018 Jul;8(3):168.

Goldstein BG, Goldstein AO, Morris-Jones R, Dellavalle RP, Levy ML, Rosen T, Ofori AO. Cutaneous warts (common, plantar, and flat warts). UpToDate.[updated 7 Mar 2018; cited 29 Jan 2019]. 2018.

Rosniza S, Azizan NZ. Liquid Nitrogen Cryotherapy Versus 20% Salicylic Acid Ointment for the Treatment of Plantar Warts–A Randomized Trial. Notice to Authors. 2017 Jan 1:43.

Buckley D. Management of Warts in General Practice. Textbook of Primary Care Dermatology. 2021:265-73.

Park JY, Park BW, Cho EB, Park EJ, Kim KH, Kim KJ. Clinical efficacy of diphenylcyclopropenone immunotherapy as monotherapy for multiple viral warts. Journal of cutaneous medicine and surgery. 2018 May;22(3):285-9.

Kim DY, Park H, Cho S, Yoon HS. Effectiveness of New 5-Fluorouracil/Salicylic Acid Application Method for Periungual Warts: A Descriptive Study. Annals of Dermatology. 2020 Aug;32(4):345.

Soenjoyo KR, Chua BW, Wee LW, Koh MJ, Ang SB. Treatment of cutaneous viral warts in children: A review. Dermatologic Therapy. 2020 Nov;33(6):e14034.

Ghiasi MM, Zendehboudi S. Decision tree-based methodology to select a proper approach for wart treatment. Computers in biology and medicine. 2019 May 1;108:400-9.

Giacaman A, Granger C, Aladren S, Bauzá A, Alomar Torrens B, Riutort Mercant M, Martin-Santiago A. Use of topical nitric–zinc complex solution to treat palmoplantar and periungual warts in a pediatric population. Dermatology and Therapy. 2019 Dec;9:755-60.

Abeck D, Tetsch L, Lüftl M, Biedermann T. Extragenital cutaneous warts–clinical presentation, diagnosis and treatment. JDDG: Journal der Deutschen Dermatologischen Gesellschaft. 2019 Jun;17(6):613-34.

Ringin SA. The effectiveness of cutaneous wart resolution with current treatment modalities. Journal of Cutaneous and Aesthetic Surgery. 2020 Jan;13(1):24.

Priya A, Adil M, Suhail Amin S, Mohtashim M, Bansal R, Alam M. Intralesional vitamin D3 in recalcitrant palmoplantar and periungual warts: a prospective, observational study. Acta Dermatovenerologica Croatica. 2019 Nov 20;27(4):215-24.

Shin DS, Han SS, Kim TL, Jang JW, Seo HM, Kim JS. Treatment of recalcitrant viral warts with combination therapy of systemic acitretin and diphenylcyclopropenone immunotherapy. Annals of Dermatology. 2020 Jun;32(3):243.

Shin YS, Cho EB, Park EJ, Kim KH, Kim KJ. A comparative study of pulsed dye laser versus long pulsed Nd: YAG laser treatment in recalcitrant viral warts. Journal of Dermatological Treatment. 2017 Jul 4;28(5):411-6.

Kuan LY, Chua SH, Pan JY, Yew YW, Tan WP. The Quadrivalent Human Papillomavirus Vaccine in Recalcitrant Acral Warts: A Retrospective Study. Ann Acad Med Singap. 2020 Oct 1;49:749-55.

Bossart S, Imstepf V, Hunger RE, Jafari SM. Nonavalent human papillomavirus vaccination as a treatment for skin warts in immunosuppressed adults: a case series. Acta dermato-venereologica. 2020 Mar 12;100(6):1-2.

Awal G, Kaur S. Therapeutic outcome of intralesional immunotherapy in cutaneous warts using the mumps, measles, and rubella vaccine: A randomized, placebo-controlled trial. The Journal of clinical and aesthetic dermatology. 2018 May;11(5):15.

AMAL A, NAHLA RG, ABOU ZEID MG. Efficacy and safety of intralesional injection of tuberculin PPD in treatment of plantar warts. The Medical Journal of Cairo University. 2019 Dec 1;87(December):4967-74.

Gianturco SL, Pavlech LL, Storm KD, Yoon S, Yuen MV, Mattingly AN. Diphenylcyclopropenone: Summary Report.

Jaiswal D. TO STUDY THE ROLE OF AUTO-IMPLANTATION THERAPY IN CUTANEOUS VIRAL WARTS (Doctoral dissertation).

Shahid SK. Recent patents in anti-wart treatment. Pharmaceutical patent analyst. 2020 Feb;9(2):53-62.

Wilson M, Wilson PJ, Wilson M, Wilson PJ. Common Warts. Close Encounters of the Microbial Kind: Everything You Need to Know About Common Infections. 2021:147-56.

Paul H, Zakaria AS, Biswas SK. Generalized Verruca Vulgaris: A case reports. Dhaka Community Med Coll Journal. 2017;6(1):29-32.

Tong Y, Tyring SK, Szalai ZZ. Human Papillomavirus Infection. Harper's Textbook of Pediatric Dermatology. 2019 Nov 20:588-97.

Sefcik RS, Burkhart CG. Wart immunotherapies: A short review. The Open Dermatology Journal. 2017 Aug 25;11(1).

Das S. Human Papillomavirus Infection: Management and Treatment. InHuman Papillomavirus 2020 Aug 7. IntechOpen.

Jaisinghani AK, Dey VK, Suresh MS, Saxena A. Bacillus Calmette–Guerin immunotherapy for recurrent multiple warts: an open-label uncontrolled study. Indian Journal of Dermatology. 2019 Mar;64(2):164.

Vania R, Pranata R, Tan ST. Intralesional measles–mumps–rubella is associated with a higher complete response in cutaneous warts: a systematic review and meta-analysis of randomized controlled trial including GRADE qualification. Journal of Dermatological Treatment. 2021 Nov 17;32(8):1010-7.

Published

13-06-2023

How to Cite

Sharif, M. M., Nasreen, S., Farooq, N., Izhar, M., Malik, T., & Dhedhi, N. A. (2023). Effectiveness of topical application of 15℅ salicyclic acid and 0.1℅ diphencyprone combined in an ointment form for treatment of plantar warts. International Journal of Health Sciences, 7(S1), 1438–1446. https://doi.org/10.53730/ijhs.v7nS1.14366

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