Assessment of antibiotic resistance patterns in enteric fever patients
A systematic review and meta analysis
Keywords:
Enteric fever, Antibiotic resistance, Resistance patterns, Enteric pathogens, Treatment outcomes, Multi-drug resistance, SurveillanceAbstract
Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi. Hence, it poses challenges in diagnosis and treatment due to variable clinical presentation and increasing antibiotic resistance. This systematic review and meta-analysis assess antibiotic resistance patterns in enteric fever patients. While discussing diagnostic methods, treatment modalities, and preventive strategies. The current literature highlights diagnostic challenges despite advancements, emphasizing the need for improved tools. So, antimicrobial resistance, particularly among younger populations, underscores the urgency for interventions. Therefore, region-specific investigation is crucial, especially for international travelers. While cephalosporins are key in treatment, tailored therapy based on local resistance patterns is required significantly. Hence prevention through vaccination and understanding carbohydrate-mediated infection strategies offers promise. Thus, further research is significantly required to address these challenges effectively and reduce the global burden of enteric infections. This study followed rigorous methodology, including systematic search strategies, quality assessment of studies, and adherence to reporting guidelines. Moreover, ethical considerations were addressed, and the protocol was registered. Overall, the study provides valuable insights into the multifaceted challenges of enteric fever and emphasizes the importance of collaborative efforts to mitigate its impact on global health.
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