Role of KI67 in response rate of neoadjuvant chemotherapy in hormonal positive breast cancer
Keywords:
neoadjuvant chemotherapy, role KI67, breast cancer, multigene testsAbstract
Introduction: A pathological complete response (pCR) after neo-adjuvant chemotherapy indicates that the outlook for individuals with breast cancer is encouraging. identifying factors, for instance the growth biomarker Ki67, that could forecast pCR, can be useful for improving understanding how drug reaction affects outcome. This research aims to evaluate Ki67's prognostic as well as prediction utility in infiltrating breast cancer patients receiving neoadjuvant treatment. Methods: After fixation and embedding, the researchers performed Ki67 staining on core biopsies taken from 552 patients. They also evaluated HER2/neu, oestrogen, progesterone receptors, and graded the samples prior to therapy. They created both univariate and multivariate models to forecast pCR and prognosis using this data. They also divided the tumors into various molecular phenotypes in order to find possible subgroups in which Ki67 could be used to forecast pCR and prognosis. Results: The researchers discovered that Ki67 was a significant autonomous pCR predictor (OR 4; 94.7% CI, 1.3 , 9), overall survival (HR 9; 96% CI, 4 to 21), and survival without illness (HR 3; 96% CI, 2 to 6) utilizing a cut-off value of > 14% positive neoplasic cell staining.
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