Advancements in nanotechnology for drug delivery
A review of recent innovations in Pharmacy-GIT as a model
Keywords:
nanoparticles, drug delivery, gastrointestinal tract, inflammatory bowel disease, colorectal cancer, lipid nanoparticlesAbstract
Background: Nanoparticles (NPs) have emerged as a transformative technology in drug delivery, offering advancements in precision medicine, especially in managing chronic diseases and gastrointestinal (GIT) disorders. Due to their unique properties and the ability to be engineered at the nanoscale, NPs provide enhanced targeting, controlled release, and reduced side effects compared to traditional drug delivery systems. Aim: This review aims to summarize recent innovations in nanoparticle technology and their applications in drug delivery systems, with a focus on gastrointestinal diseases. Methods: The review synthesizes current literature on NP technologies and their applications in treating GIT disorders. It covers a range of nanocarriers, including metal and polymeric NPs, liposomes, hydrogels, and lipid nanoparticles. The review evaluates their effectiveness, challenges, and advancements in GIT drug delivery. Results: Recent advancements in NP technology have demonstrated significant potential in improving drug delivery to the GIT. Innovations include pH-sensitive NPs, enzyme-responsive NPs, and targeted formulations for diseases such as inflammatory bowel disease (IBD) and colorectal cancer. Lipid nanoparticles, including solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs), have shown promise in enhancing stability, targeting, and drug release profiles.
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