Gestational diabetes: Current trends in treatment and long-term complications

https://doi.org/10.53730/ijhs.v3nS1.15218

Authors

  • Alaa Saud Aleiid KSA, National Guard Health Affairs
  • Alaa Musaad Alsayyari KSA, National Guard Health Affairs
  • Abdullah Atiyyan Albishri KSA, National Guard Health Affairs
  • Sawsan Ahmad Ghassap KSA, National Guard Health Affairs
  • Samirah Ali Alamri KSA, National Guard Health Affairs
  • Abdulaziz Mohammed Almuhaylib KSA, National Guard Health Affairs
  • Hamad Dafalh Alrakhimy KSA, National Guard Health Affairs

Keywords:

gestational diabetes, screening, management, long-term complications, type 2 diabetes, obesity

Abstract

Background: Gestational diabetes mellitus (GDM) is characterized by carbohydrate intolerance first recognized during pregnancy. Its prevalence varies globally, influenced by diagnostic criteria and demographic factors, with recent estimates indicating that one in seven live births worldwide is affected. Rising obesity rates, sedentary lifestyles, and advancing maternal age contribute to this trend. Aim: This article reviews current trends in GDM treatment and examines long-term complications for both mothers and offspring. Methods: A comprehensive literature review was conducted, encompassing guidelines from major health organizations and recent cohort studies on GDM screening, diagnosis, management, and outcomes. Results: The review identified variations in screening practices across guidelines, with consensus recommending universal screening during the second trimester, though early screening in high-risk populations is increasingly advocated. GDM management strategies include dietary interventions, physical activity, and insulin therapy as needed. Long-term studies indicate that women with a history of GDM face increased risks of developing type 2 diabetes, while offspring are at higher risk for obesity and metabolic syndrome. Conclusion: Given the rising incidence of GDM and its potential long-term complications, tailored screening and management strategies are essential. Ongoing research into the pathophysiology and effective interventions will enhance outcomes for affected individuals.

Downloads

Download data is not yet available.

References

World Health Organization (1999) Definition, Diagnosis and Classi fication of Diabetes Mellitus and its Complications. Part 1: Diagnosis and Classification of Diabetes Mellitus, World Health Organization

Scottish Intercollegiate Guidelines Network (2010) Management of Diabetes. SIGN Guideline 116, SIGN

American Diabetes Association (2018) Classification and diagno sis of diabetes: standards of medical care in diabetes—2018. Diabetes Care 41, S13–S27 DOI: https://doi.org/10.2337/dc18-S002

Farrar, D. et al. (2016) The identification and treatment of women with hyperglycaemia in pregnancy: an analysis of individual participant data, systematic reviews, meta-analyses and an economic evaluation. Health Technol. Assess. 20, 1 348 DOI: https://doi.org/10.3310/hta20860

Sacks, D.A. et al. (2012) Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Diabetes Care 35, 526 528 DOI: https://doi.org/10.2337/dc11-1641

International Diabetes Federation (2017) IDF Diabetes Atlas 2017. (8th edn), International Diabetes Federation.

Lavery, J. et al. (2017) Gestational diabetes in the United States: temporal changes in prevalence rates between 1979 and 2010. BJOG 124, 804–813 DOI: https://doi.org/10.1111/1471-0528.14236

International Association of Diabetes and Pregnancy Study Groups Consensus Panel (2010) International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care 33, 676–682 DOI: https://doi.org/10.2337/dc09-1848

World Health Organization (2013) Diagnostic Criteria and Classi fication of Hyperglycaemia First Detected in Pregnancy, World Health Organization

National Institute for Health and Care Excellence (2015) Diabetes in Pregnancy: Management from Preconception to the Postnatal Period, NICE Guideline (NG3)

The American College of Obstetricians and Gynaecologists (2018) ACOG practice bulletin No. 190: gestational diabetes mellitus. Obstet. Gynaecol. 131, e49–e64 DOI: https://doi.org/10.1097/AOG.0000000000002501

Diabetes Canada Clinical Practice Guidelines Expert Committee (2018) 2018 Clinical Practice Guidelines. Diabetes and Preg nancy. Can. J. Diabetes 42, S255–S282 DOI: https://doi.org/10.1016/S1499-2671(17)31026-2

McIntyre, H.D. et al. (2016) Issues with the diagnosis and classifi cation of hyperglycemia in early pregnancy. Diabetes Care 39, 53–54 DOI: https://doi.org/10.2337/dc15-1887

Zhu, W. et al. (2013) Evaluation of the value of fasting plasma glucose in the first prenatal visit to diagnose gestational diabetes mellitus in China. Diabetes Care 36, 586–590 DOI: https://doi.org/10.2337/dc12-1157

Huhn, E.A. et al. (2016) Screening of gestational diabetes mellitus in early pregnancy by oral glucose tolerance test and glycosylated fibronectin: study protocol for an international, prospective, multi centre cohort trial. BMJ Open 6,e012115 http://dx.doi.org/ 10.1136/bmjopen-2016-012115 DOI: https://doi.org/10.1136/bmjopen-2016-012115

Liu, B. et al. (2016) Early Diagnosis of Gestational Diabetes Mellitus (EDoGDM) study: a protocol for a prospective, longitu dinal cohort study. BMJ Open 6, e012315 DOI: https://doi.org/10.1136/bmjopen-2016-012315

The HAPOStudy CooperativeResearch Group (2008)Hyperglycemia and adverse pregnancy outcomes. N. Engl. J. Med. 358, 1991–2002 DOI: https://doi.org/10.1056/NEJMoa0707943

Huhn, E.A. et al. (2017) Fourfold increase in prevalence of gesta tional diabetes mellitus after adoption of the new International Association of Diabetes and Pregnancy Study Groups (IADPSG) criteria. J. Perinat. Med. 45, 359–366 DOI: https://doi.org/10.1515/jpm-2016-0099

Duran, A. et al. (2014) Introduction of IADPSG criteria for the screening and diagnosis of gestational diabetes mellitus results in improved pregnancy outcomes at a lower cost in a large cohort of pregnant women: the St. Carlos Gestational Diabetes Study. Diabetes Care 37, 2442–2450 DOI: https://doi.org/10.2337/dc14-0179

Catalano, P.M. et al. (1991) Longitudinal changes in insulin release and insulin resistance in nonobese pregnant women. Am. J. Obstet. Gynecol. 165, 1667–1672 DOI: https://doi.org/10.1016/0002-9378(91)90012-G

Catalano, P.M. et al. (1992) Longitudinal changes in basal hepatic glucose production and suppression during insulin infusion in normal pregnant women. Am. J. Obstet. Gynecol. 167, 913–919 DOI: https://doi.org/10.1016/S0002-9378(12)80011-1

Catalano, P.M. et al. (1993) Carbohydrate metabolism during pregnancy in control subjects and women with gestational dia betes. Am. J. Physiol. Metab. 264, E60–E67 DOI: https://doi.org/10.1152/ajpendo.1993.264.1.E60

Ryan, E.A. et al. (1985) Insulin action during pregnancy. Studies with the euglycemic clamp technique. Diabetes 34, 380–389 DOI: https://doi.org/10.2337/diabetes.34.4.380

Catalano, P.M. (2014) Trying to understand gestational diabetes. Diabet. Med. 31, 273–281 DOI: https://doi.org/10.1111/dme.12381

Catalano, P.M. et al. (1999) Longitudinal changes in glucose metabolism during pregnancy in obese women with normal glu cose tolerance and gestational diabetes mellitus. Am. J. Obstet. Gynecol. 180, 903–916 DOI: https://doi.org/10.1016/S0002-9378(99)70662-9

Berkowitz, G.S. et al. (1992) Race/ethnicity and other risk factors for gestational diabetes. Am. J. Epidemiol. 135, 965–973 DOI: https://doi.org/10.1093/oxfordjournals.aje.a116408

Chu, S.Y. et al. (2007) Maternal obesity and risk of gestational diabetes mellitus. Diabetes Care 30, 2070–2076 DOI: https://doi.org/10.2337/dc06-2559a

Kim, S.Y. et al. (2010) Percentage of gestational diabetes mellitus attributable to overweight and obesity. Am. J. Public Health 100, 1047–1052 DOI: https://doi.org/10.2105/AJPH.2009.172890

Omori, S. et al. (2008) Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. Diabetes 57, 791 795 DOI: https://doi.org/10.2337/db07-0979

Gudmundsson, J. et al. (2007) Two variants on chromosome 17 confer prostate cancer risk and the one in TCF2 protects against type 2 diabetes. Nat. Genet. 39, 977–983

Zhang, X. et al. (2012) Association of single nucleotide polymor phisms in TCF2 with type 2 diabetes susceptibility in a Han Chinese population. PLoS One 7, e52938 DOI: https://doi.org/10.1371/journal.pone.0052938

Lauenborg, J. et al. (2009) Common type 2 diabetes risk gene variants associate with gestational diabetes. J. Clin. Endocrinol. Metab. 94, 145–150 DOI: https://doi.org/10.1210/jc.2008-1336

Huopio, H. et al. (2013) Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes. Eur. J. Endocrinol. 169, 291–297 DOI: https://doi.org/10.1530/EJE-13-0286

Freathy, R.M. et al. (2010) Hyperglycemia and Adverse Preg nancy Outcome (HAPO) Study: common genetic variants in GCK and TCF7L2 are associated with fasting and postchal lenge glucose levels in pregnancy and with the new consen sus definition of gestational diabetes mellitus from the International Association of Diabetes and Pregnancy Study Groups. Diabetes 59, 2682–2689 DOI: https://doi.org/10.2337/db10-0177

Kwak, S.H. et al. (2012) A genome-wide association study of gestational diabetes mellitus in Korean women. Diabetes 61, 531–541 DOI: https://doi.org/10.2337/db11-1034

Alcolado, J.C. and Alcolado, R. (1991) Importance of maternal history of non-insulin dependent diabetic patients. BMJ 302, 1178–1180 DOI: https://doi.org/10.1136/bmj.302.6786.1178

Thomas, F. et al. (1994) Maternal effect and familial aggregeation in NIDDM. The CODIAB study. Diabetes 43, 63–67 DOI: https://doi.org/10.2337/diabetes.43.1.63

Lindsay, R.S. et al. (2000) Type 2 diabetes and low birth weight: the role of paternal inheritance in the association of low birth weight and diabetes. Diabetes 49, 445–449 DOI: https://doi.org/10.2337/diabetes.49.3.445

Martin, A.O. et al. (1985) Frequency of diabetes mellitus in moth ers of probands with gestational diabetes: possible maternal influence on the predisposition to gestational diabetes. Am. J. Obstet. Gynecol. 151, 471–475 DOI: https://doi.org/10.1016/0002-9378(85)90272-8

Meigs, J.B. et al. (2000) Parental transmission of type 2 diabetes: the Framingham Offspring Study. Diabetes 49, 2201–2207 DOI: https://doi.org/10.2337/diabetes.49.12.2201

Dabelea, D. et al. (2000) Intrauterine exposure to diabetes con veys risks for type 2 diabetes and obesity: a study of discordant sibships. Diabetes 49, 2208–2211 DOI: https://doi.org/10.2337/diabetes.49.12.2208

Atègbo, J.-M. et al. (2006) Modulation of adipokines and cyto kines in gestational diabetes and macrosomia. J. Clin. Endocrinol. Metab. 91, 4137–4143 DOI: https://doi.org/10.1210/jc.2006-0980

Wolf, M. et al. (2004) Inflammation and glucose intolerance: a prospective study of gestational diabetes mellitus. Diabetes Care 27, 21–27 DOI: https://doi.org/10.2337/diacare.27.1.21

Pantham, P. et al. (2015) Inflammation in maternal obesity and gestational diabetes mellitus. Placenta 36, 709–715 DOI: https://doi.org/10.1016/j.placenta.2015.04.006

Fernández-Morera, J.L. et al. (2010) The possible role of epige netics in gestational diabetes: cause, consequence, or both. Obstet. Gynecol. Int. 2010, 1–7 DOI: https://doi.org/10.1155/2010/605163

Kwak, S.H. and Park, K.S. (2016) Recent progress in genetic and epigenetic research on type 2 diabetes. Exp. Mol. Med. 48, e220 DOI: https://doi.org/10.1038/emm.2016.7

Billionnet, C. et al. (2017) Gestational diabetes and adverse perinatal outcomes from 716,152 births in France in 2012. Dia betologia 60, 636–644 DOI: https://doi.org/10.1007/s00125-017-4206-6

O’Sullivan, E.P. et al. (2011) Atlantic diabetes in pregnancy (DIP): the prevalence and outcomes of gestational diabetes mellitus using new diagnostic criteria. Diabetologia 54, 1670–1675 DOI: https://doi.org/10.1007/s00125-011-2150-4

Mortier, I. et al. (2017) Is gestational diabetes an independent risk factor of neonatal severe respiratory distress syndrome after 34 weeks of gestation? A prospective study. Arch. Gynecol. Obstet. 296, 1071–1077 DOI: https://doi.org/10.1007/s00404-017-4505-7

Wendland, E.M. et al. (2012) Gestational diabetes and pregnancy outcomes a systematic review of the World Health Organization (WHO) and the International Association of Diabetes in Pregnancy. DOI: https://doi.org/10.1186/1471-2393-12-23

Fadl, H.E. et al. (2010) Maternal and neonatal outcomes and time trends of gestational diabetes mellitus in Sweden from 1991 to 2003. Diabet. Med. 27, 436–441 DOI: https://doi.org/10.1111/j.1464-5491.2010.02978.x

Feig, D.S. et al. (2014) Trends in incidence of diabetes in pregnancy and serious perinatal outcomes: a large, population-based study in Ontario, Canada, 1996–2010. Diabetes Care 37, 1590–1596 DOI: https://doi.org/10.2337/dc13-2717

García-Patterson, A. et al. (2004) In human gestational diabetes mellitus congenital malformations are related to pre-pregnancy body mass index and to severity of diabetes. Diabetologia 47, 509–514 DOI: https://doi.org/10.1007/s00125-004-1337-3

Krishnaveni, G.V. et al. (2010) Intrauterine exposure to maternal diabetes is associated with higher adiposity and insulin resistance and clustering of cardiovascular risk markers in Indian children. Diabetes Care 33, 402–404 DOI: https://doi.org/10.2337/dc09-1393

Wu, C.S. et al. (2012) Long-term health outcomes in children born to mothers with diabetes: a population-based cohort study. PLoS One 7, e36727 DOI: https://doi.org/10.1371/journal.pone.0036727

Kelstrup, L. et al. (2013) Insulin resistance and impaired pancre atic b-cell function in adult offspring of women with diabetes in pregnancy. J. Clin. Endocrinol. Metab. 98, 3793–3801 DOI: https://doi.org/10.1210/jc.2013-1536

Damm, P. et al. (2016) Gestational diabetes mellitus and long term consequences for mother and offspring: a view from Denmark. Diabetologia 59, 1396–1399 DOI: https://doi.org/10.1007/s00125-016-3985-5

Schwartz, N. et al. (2015) The prevalence of gestational diabetes mellitus recurrence—effect of ethnicity and parity: a metaanalysis. Am. J. Obstet. Gynecol. 213, 310–317 DOI: https://doi.org/10.1016/j.ajog.2015.03.011

MacNeill, S. et al. (2001) Rates and risk factors for recurrence of gestational diabetes. Diabetes Care 24, 659–662 DOI: https://doi.org/10.2337/diacare.24.4.659

Bellamy, L. et al. (2009) Type 2 diabetes mellitus after gestational diabetes: a systematic review and meta-analysis. Lancet 373, 1773–1779 DOI: https://doi.org/10.1016/S0140-6736(09)60731-5

Cheung, N.W. and Byth, K. (2003) Population health significance of gestational diabetes. Diabetes Care 26, 2005–2009 DOI: https://doi.org/10.2337/diacare.26.7.2005

Kim, C. et al. (2002) Gestationaldiabetes and the incidenceof type 2 diabetes: a systematic review. Diabetes Care 25, 1862–1868 DOI: https://doi.org/10.2337/diacare.25.10.1862

Crowther, C.A. et al. (2005) Effect of treatment of gestational diabetes mellitus on pregnancy outcomes. N. Engl. J. Med. 352, 2477–2486 DOI: https://doi.org/10.1056/NEJMoa042973

Landon, M.B. et al. (2009) A multicenter, randomized trial of treatment for mild gestational diabetes. N. Engl. J. Med. 361, 1339–1348 DOI: https://doi.org/10.1056/NEJMoa0902430

American Diabetes Association (2018) Management of diabetes in pregnancy: standards of medical care in diabetes-2018. Dia betes Care 41, S137–S143 DOI: https://doi.org/10.2337/dc18-S013

Institute of Medicine (2009) Weight Gain During Pregnancy: Re examining the Guidelines, National Academies Press

Yamamoto, J.M. et al. (2018) Gestational diabetes mellitus and diet: a systematic review and meta-analysis of randomized con trolled trials examining the impact of modified dietary interven tions on maternal glucose control and neonatal birth weight. Diabetes Care 41, 1346–1361 DOI: https://doi.org/10.2337/dc18-0102

Brown, J. et al. (2015) Lifestyle interventions for the treatment of women with gestational diabetes. Cochrane Database Syst. Rev. 5, CD011970 DOI: https://doi.org/10.1002/14651858.CD011970

Shepherd, E. et al. (2017) Combined diet and exercise interven tions for preventing gestational diabetes mellitus. Cochrane Data base Syst. Rev. 11, CD010443 DOI: https://doi.org/10.1002/14651858.CD010443.pub3

Blum, A.K. (2016) Insulin use in pregnancy: an update. Diabetes Spectr. 29, 92–97 DOI: https://doi.org/10.2337/diaspect.29.2.92

Rowan, J.A. et al. (2008) Metformin versus insulin for the treat ment of gestational diabetes. N. Engl. J. Med. 358, 2003–2015 DOI: https://doi.org/10.1056/NEJMoa0707193

Langer, O. et al. (2000) Comparison of glyburide and insulin in women with gestational diabetes mellitus. N. Engl. J. Med. 343, 1134–1138 DOI: https://doi.org/10.1056/NEJM200010193431601

Reynolds, R.M. et al. (2017) Glibenclamide and metformin versus standard care in gestational diabetes (GRACES): a feasibility open label randomised trial. BMC Pregnancy Childbirth 17, 316 DOI: https://doi.org/10.1186/s12884-017-1505-3

Balsells, M. et al. (2015) Glibenclamide, metformin, and insulin for the treatment of gestational diabetes: a systematic review and meta-analysis. BMJ 350, h102 DOI: https://doi.org/10.1136/bmj.h102

Brown, J. et al. (2017) Oral anti-diabetic pharmacological thera pies for the treatment of women with gestational diabetes. Cochrane Database Syst. Rev. 1, CD011967 DOI: https://doi.org/10.1002/14651858.CD011967.pub2

Barbour, L.A. et al. (2018) A cautionary response to SMFM statement: pharmacological treatment of gestational diabetes. Am. J. Obstet. Gynecol. Published online June 28, 2018. http://dx.doi.org/10.1016/j.ajog.2018.06.013 DOI: https://doi.org/10.1016/j.ajog.2018.06.013

Charles, B. et al. (2006) Population pharmacokinetics of metfor min in late pregnancy. Ther. Drug Monit. 28, 67–72 DOI: https://doi.org/10.1097/01.ftd.0000184161.52573.0e

Given, J.E. et al. (2018) Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: explor atory case-control study. BMJ 361, k2477 DOI: https://doi.org/10.1136/bmj.k2477

Lindsay, R.S. and Loeken, M.R. (2017) Metformin use in preg nancy: promises and uncertainties. Diabetologia 60, 1612–1619 DOI: https://doi.org/10.1007/s00125-017-4351-y

Aroda, V.R. et al. (2015) The effect of lifestyle intervention and metformin on preventing or delaying diabetes among women with and without gestational diabetes: the Diabetes Prevention Pro gram Outcomes Study 10-year follow-up. J. Clin. Endocrinol. Metab. 100, 1646–1653 DOI: https://doi.org/10.1210/jc.2014-3761

Wexler, D.J. et al. (2018) Research gaps in gestational diabetes mellitus: executive summary of a National Institute of Diabetes and Digestive and Kidney Diseases workshop. Obstet. Gynecol. 132, 1 DOI: https://doi.org/10.1097/AOG.0000000000002908

Published

15-01-2019

How to Cite

Aleiid, A. S., Alsayyari, A. M., Albishri, A. A., Ghassap, S. A., Alamri, S. A., Almuhaylib, A. M., & Alrakhimy, H. D. (2019). Gestational diabetes: Current trends in treatment and long-term complications. International Journal of Health Sciences, 3(S1), 352–368. https://doi.org/10.53730/ijhs.v3nS1.15218

Issue

Section

Peer Review Articles

Most read articles by the same author(s)

1 2 > >>