Postpartum hemorrhage management and nursing care interventions: An updated review
Keywords:
Postpartum hemorrhage, uterine atony, skin-to-skin contact, breastfeeding, oxytocin, third stage of labor, maternal careAbstract
Background: Postpartum hemorrhage (PPH) is a leading cause of maternal mortality globally, contributing to approximately 27.1% of maternal deaths. The primary cause of PPH is uterine atony, characterized by the failure of the uterus to contract after childbirth. Despite active management strategies like exogenous oxytocin administration, PPH rates have not significantly decreased, and there is growing evidence suggesting adverse effects from medical interventions such as oxytocin. Alternative methods like skin-to-skin contact (SSC) and early breastfeeding have emerged as promising preventive measures. Aim: The aim of this review is to examine the role of SSC and early breastfeeding in preventing PPH, focusing on their effects on the duration of the third stage of labor, postpartum blood loss, and the underlying physiological mechanisms. Methods: This updated review synthesizes evidence from numerous studies on PPH prevention, with a particular emphasis on physiological management strategies. We explore the impact of SSC and early breastfeeding on uterine contraction and oxytocin production, as well as their role in mitigating blood loss during the third stage of labor. Results: Evidence suggests that SSC and early breastfeeding stimulate endogenous oxytocin production, facilitating uterine contraction and potentially reducing PPH.
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World Health Organization. Maternal Mortality: Level and Trends 2000 to 2017. In Sexual and Reproductive Health; World Health Organization: Geneva, Switzerland, 2019; Available online: https://www.who.int/reproductivehealth/publications/maternal-mortality-2000-2017/en/
Say, L.; Chou, D.; Gemmill, A.; Tunçalp, Ö.; Moller, A.B.; Daniels, J.; Gülmezoglu, A.M.; Temmerman, M.; Alkema, L. Global causes of maternal death: A WHO systematic analysis. Lancet Glob. Health. 2014, 2, e323–e333. DOI: https://doi.org/10.1016/S2214-109X(14)70227-X
Knight, M.; Callaghan, W.M.; Berg, C.; Alexander, S.; Bouvier-Colle, M.-H.; Ford, J.B.; Joseph, K.S.; Lewis, G.; Liston, R.M.; Roberts, C.L.; et al. Trends in postpartum hemorrhage in high resource countries: A review and recommendations from the International Postpartum Hemorrhage Collaborative Group. BMC Pregnancy Childbirth 2009, 9, 1–10. DOI: https://doi.org/10.1186/1471-2393-9-55
Begley, C.M. Intervention or interference? The need for expectant care throughout normal labour. Sex. Reprod. Healthc. 2014, 5, 160–164. DOI: https://doi.org/10.1016/j.srhc.2014.10.004
Dixon, L.; Tracy, S.K.; Guilliland, K.; Fletcher, L.; Hendry, C.; Pairman, S. Outcomes of physiological and active third stage labour care amongst women in New Zealand. Midwifery 2013, 29, 67–74. DOI: https://doi.org/10.1016/j.midw.2011.11.003
Grotegut, C.A.; Paglia, M.J.; Johnson, L.N.C.; Thames, B.; James, A.H. Oxytocin exposure during labor among women with postpartum hemorrhage secondary to uterine atony. Am. J. Obstet. Gynecol. 2011, 204, 56.e1–56.e6. DOI: https://doi.org/10.1016/j.ajog.2010.08.023
Saxton, A.; Fahy, K.; Hastie, C. Effects of skin-to-skin contact and breastfeeding at birth on the incidence of PPH: A physiologically based theory. Women Birth 2014, 27, 250–253. DOI: https://doi.org/10.1016/j.wombi.2014.06.004
Fahy, K.; Hastie, C.; Bisits, A.; Marsh, C.; Smith, L.; Saxton, A. Holistic physiological care compared with active management of the third stage of labour for women at low risk of postpartum haemorrhage: A cohort study. Women Birth 2015, 23, 146–152. DOI: https://doi.org/10.1016/j.wombi.2010.02.003
Hastie, C.; Fahy, K.M. Optimising psychophysiology in third stage of labour: Theory applied to practice. Women Birth 2009, 22, 89–96. DOI: https://doi.org/10.1016/j.wombi.2009.02.004
Karimi, F.Z.; Sadeghi, R.; Maleki-Saghooni, N.; Khadivzadeh, T. The effect of mother-infant skin to skin contact on success and duration of first breastfeeding: A systematic review and meta-analysis. Taiwan. J. Obstet. Gynecol. 2019, 58, 1–9. DOI: https://doi.org/10.1016/j.tjog.2018.11.002
Safari, K.; Saeed, A.A.; Hasan, S.S.; Moghaddam-Banaem, L. The effect of mother and newborn early skin-to-skin contact on initiation of breastfeeding, newborn temperature and duration of third stage of labor. Int. Breastfeed. J. 2018, 13, 1–8. DOI: https://doi.org/10.1186/s13006-018-0174-9
Mejbel, M.K.; Ali, R.M.; Assist, P.; Baghdad, N. Effectiveness of Skin- to Skin Contact on duration of third stage of labor in Baghdad Teaching Hospital: Comparative Study. Kufa J. Nurs. Sci. 2012, 2, 1–14. DOI: https://doi.org/10.36321/kjns.vi20123.2523
World Health Organization. WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage; World Health Organization: Geneva, Switzerland, 2012; 41p, Available online: http://www.who.int/reproductivehealth/publications/maternal_perinatal_health/9789241548502/en/
Rcog, Royal College of Obstetricians and Gynaecologists. Prevention and Management of Post-Partum Haemorrhage. Green Top Guidelines 52. 2011. Available online: http://www.rcog.org.uk/files/rcog-corp/GT52PostpartumHaemorrhage0411.pdf
American College of Obstetricians & Gynecologists. ACOG practice bulletin no. 76: Postpartum hemorrhage. Obs. Gynecol. 2006, 108, 1039–1047. DOI: https://doi.org/10.1097/00006250-200610000-00046
Shields, L.E.; Goffman, D.; Caughey, A.B. ACOG practice bulletin: Clinical management guidelines for obstetrician-gynecologists. Obstet. Gynecol. 2017, 130, e168–e186.
Almutairi, W.M.; Ludington, S.M.; Quinn Griffin, M.T.; Burant, C.J.; Al-Zahrani, A.E.; Alshareef, F.H.; Badr, H.A. The Role of Skin-to-Skin Contact and Breastfeeding on Atonic Postpartum Hemorrhage. Nurs. Rep. 2020, 11, 1–11. DOI: https://doi.org/10.3390/nursrep11010001
Almutairi, W.M. Incidences of Atonic Postpartum Hemorrhage and Related Risk Factors at a Tertiary Hospital in Saudi Arabia. Nurs. Rep. 2020, 10, 164–171. DOI: https://doi.org/10.3390/nursrep10020020
Kramer, M.S.; Berg, C.; Abenhaim, H.; Dahhou, M.; Rouleau, J.; Mehrabadi, A.; Joseph, K.S. Incidence, risk factors, and temporal trends in severe postpartum hemorrhage. Am. J. Obstet. Gynecol. 2013, 209, 449.e1–449.e7. DOI: https://doi.org/10.1016/j.ajog.2013.07.007
Chelmow, D. Postpartum haemorrhage: Prevention. Clin. Evid. 2011, 4, 1410.
Calvert, C.; Thomas, S.L.; Ronsmans, C.; Wagner, K.S.; Adler, A.J.; Filippi, V. Identifying regional variation in the prevalence of postpartum haemorrhage: A systematic review and meta-analysis. PLoS ONE 2012, 7, e41114. DOI: https://doi.org/10.1371/journal.pone.0041114
Belghiti, J.; Kayem, G.; Dupont, C.; Rudigoz, R.C.; Bouvier-Colle, M.H.; Deneux-Tharaux, C. Oxytocin during labour and risk of severe postpartum haemorrhage: A population-based, cohort-nested case-control study. BMJ Open 2011, 1, e000514. DOI: https://doi.org/10.1136/bmjopen-2011-000514
Clark, S.L.; Simpson, K.R.; Knox, G.E.; Garite, T.J. Oxytocin: New perspectives on an old drug. Am. J. Obstet. Gynecol. 2009, 200, 35.e1–35.e6. DOI: https://doi.org/10.1016/j.ajog.2008.06.010
Rossen, J.; Okland, I.; Nilsen, O.B.; Eggebø, T. Is there an increase of postpartum hemorrhage, and is severe hemorrhage associated with more frequent use of obstetric interventions? Acta Obstet. Gynecol. Scand. 2010, 89, 1248–1255. DOI: https://doi.org/10.3109/00016349.2010.514324
Lisonkova, S.; Mehrabadi, A.; Allen, V.M.; Bujold, E.; Crane, J.M.G.; Gaudet, L.; Gratton, R.J.; Ladhani, N.N.N.; Olatunbosun, O.A.; Joseph, K.S. Atonic Postpartum Hemorrhage: Blood Loss, Risk Factors, and Third Stage Management. J. Obstet. Gynaecol. Can. 2016, 38, 1081–1090.e2. DOI: https://doi.org/10.1016/j.jogc.2016.06.014
Bateman, B.T.; Berman, M.F.; Riley, L.E.; Leffert, L.R. The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries. Anesth. Analg. 2010, 110, 1368–1373. DOI: https://doi.org/10.1213/ANE.0b013e3181d74898
Grobman, W.A.; Bailit, J.L.; Rice, M.M.; Wapner, R.J.; Reddy, U.M.; Varner, M.W.; Thorp, J.M.J.; Leveno, K.J.; Caritis, S.N.; Iams, J.D.; et al. Frequency of and factors associated with severe maternal morbidity. Obstet. Gynecol. 2014, 123, 804–810. DOI: https://doi.org/10.1097/AOG.0000000000000173
Montufar-Rueda, C.; Rodriguez, L.; Jarquin, J.D.; Barboza, A.; Bustillo, M.C.; Marin, F.; Ortiz, G.; Estrada, F. Severe postpartum hemorrhage from uterine atony: A multicentric study. J. Pregnancy 2013, 2013, 525914. DOI: https://doi.org/10.1155/2013/525914
Thompson, J.F.; Heal, L.J.; Roberts, C.L.; Ellwood, D.A. Women’s breastfeeding experiences following a significant primary postpartum haemorrhage: A multicentre cohort study. Int. Breastfeed. J. 2010, 5, 1–12. DOI: https://doi.org/10.1186/1746-4358-5-5
Maswime, S.; Buchmann, E. A systematic review of maternal near miss and mortality due to postpartum hemorrhage. Int. J. Gynecol. Obstet. 2017, 137, 1–7. DOI: https://doi.org/10.1002/ijgo.12096
Feduniw, S.; Warzecha, D.; Szymusik, I.; Wielgos, M. Epidemiology, prevention and management of early postpartum hemorrhage—A systematic review. Ginekol. Pol. 2020, 91, 45–51. DOI: https://doi.org/10.5603/GP.2020.0009
Oyelese, Y.; Ananth, C.V. Postpartum hemorrhage: Epidemiology, risk factors, and causes. Clin. Obstet. Gynecol. 2010, 53, 147–156. DOI: https://doi.org/10.1097/GRF.0b013e3181cc406d
Su, C.W. Postpartum hemorrhage. Prim. Care 2012, 39, 167–187. DOI: https://doi.org/10.1016/j.pop.2011.11.009
Lancaster, L.; Barnes, R.F.W.; Correia, M.; Luis, E.; Boaventura, I.; Silva, P.; Drygalski, A. Maternal death and postpartum hemorrhage in sub-Saharan Africa—A pilot study in metropolitan Mozambique. Res. Pract. Thromb. Haemost. 2020, 4, 402–412. DOI: https://doi.org/10.1002/rth2.12311
Ekin, A.; Gezer, C.; Solmaz, U.; Taner, C.E.; Dogan, A.; Ozeren, M. Predictors of severity in primary postpartum hemorrhage. Arch. Gynecol. Obstet. 2015, 292, 1247–1254. DOI: https://doi.org/10.1007/s00404-015-3771-5
Mehrabadi Azar Hutcheon, J.A.; Lee, L.; Liston, R.M.; Joseph, K. Trends in postpartum hemorrhage from 2000 to 2009: A population-based study. BMC Pregnancy Childbirth 2012, 12, 1–9. DOI: https://doi.org/10.1186/1471-2393-12-108
Nyfløt, L.T.; Sandven, I.; Stray-Pedersen, B.; Pettersen, S.; Al-Zirqi, I.; Rosenberg, M.; Jacobsen, A.F.; Vangen, S. Risk factors for severe postpartum hemorrhage: A case-control study. BMC Pregnancy Childbirth 2017, 17, 1–9. DOI: https://doi.org/10.1186/s12884-016-1217-0
Ngwenya, S. Postpartum hemorrhage: Incidence, risk factors, and outcomes in a low-resource setting. Int. J. Women’s Health 2016, 8, 647–650 DOI: https://doi.org/10.2147/IJWH.S119232
Filho, E.A.R.; Costa, M.L.; Cecatti, J.G.; Parpinelli, M.A.; Haddad, S.M.; Pacagnella, R.C.; Sousa, M.H.; Melo, E.F.; Surita, F.G.; Souza, J.P. Severe maternal morbidity and near miss due to postpartum hemorrhage in a national multicenter surveillance study. Int. J. Gynaecol. Obstet. 2015, 128, 131–136. DOI: https://doi.org/10.1016/j.ijgo.2014.08.023
Lowe, N.K. The persistent problem of postpartum hemorrhage. J. Obstet. Gynecol. Neonatal Nurs. 2012, 41, 459–460. DOI: https://doi.org/10.1111/j.1552-6909.2012.01397.x
Sheldon, W.R.; Blum, J.; Vogel, J.P.; Souza, J.P.; Gülmezoglu a, M.; Winikoff, B.; on behalf of the WHO Multicountry Survey on Maternal and Newborn Health Research Network. Postpartum haemorrhage management, risks, and maternal outcomes: Findings from the World Health Organization Multicountry Survey on Maternal and Newborn Health. BJOG Int. J. Obstet. Gynaecol. 2014, 121, 5–13. DOI: https://doi.org/10.1111/1471-0528.12636
WHO. WHO Recommendations for the Prevention of Postpartum Haemorrhage; WHO: Geneva, Switzerland, 2006; pp. 1–6. Available online: http://scholar.google.com/scholar?hl=en&btnG=Search&q=intitle:WHO+Recommendations+for+the+Prevention+of+Postpartum+Haemorrhage#0
Driessen, M.; Bouvier-Colle, M.H.; Dupont, C.; Khoshnood, B.; Rudigoz, R.C.; Deneux-Tharaux, C.; Pithagore6 Group. Postpartum hemorrhage resulting from uterine atony after vaginal delivery: Factors associated with severity. Obstet. Gynecol. 2011, 117, 21–31. DOI: https://doi.org/10.1097/AOG.0b013e318202c845
Clark, S.L. Obstetric hemorrhage. Semin. Perinatol. 2016, 40, 109–111. DOI: https://doi.org/10.1053/j.semperi.2015.11.016
Pejovic, N.J.; Herlenius, E. Unexpected collapse of healthy newborn infants: Risk factors, supervision and hypothermia treatment. Acta Paediatr. Int. J. Paediatr. 2013, 102, 680–688. DOI: https://doi.org/10.1111/apa.12244
Lutomski, J.E.; Byrne, B.M.; Devane, D.; Greene, R.A. Increasing trends in atonic postpartum haemorrhage in Ireland: An 11-year population-based cohort study. BJOG Int. J. Obstet. Gynaecol. 2012, 119, 306–314. DOI: https://doi.org/10.1111/j.1471-0528.2011.03198.x
Al-Kadri, H.M.; Tariq, S.; Tamim, H.M. Risk factors for postpartum hemorrhage among Saudi women. Saudi Med. J. 2009, 30, 1305–1310.
Manuscript, A. NIH Public Access. Changes 2012, 29, 997–1003.
Saxton, A.; Fahy, K.; Hastie, C. Pronurturance Plus at birth: A risk reduction strategy for preventing postpartum haemorrhage. Women Birth 2016, 29, 279–284. DOI: https://doi.org/10.1016/j.wombi.2015.11.007
Smit, M.; van Stralen, G.; Wolterbeek, R.; van Dillen, J.; van Roosmalen, J.; Slootweg, Y. Survey of prophylactic use of uterotonics in the third stage of labour in the Netherlands. Midwifery 2013, 29, 859–862. DOI: https://doi.org/10.1016/j.midw.2012.09.004
Gülmezoglu, A.M.; Lumbiganon, P.; Landoulsi, S.; Widmer, M.; Abdel-Aleem, H.; Festin, M.; Carroli, G.; Qureshi, Z.; Souza, J.P.; Bergel, E.; et al. Active management of the third stage of labour with and without controlled cord traction: A randomised, controlled, non-inferiority trial. Lancet 2012, 379, 1721–1727. DOI: https://doi.org/10.1016/S0140-6736(12)60206-2
Fahy, K.M. Third stage of labour care for women at low risk of postpartum haemorrhage. J. Midwifery Womens Health 2009, 54, 380–386. DOI: https://doi.org/10.1016/j.jmwh.2008.12.016
Zimet, G.D.; Dahlem, N.W.; Zimet, S.G.; Farley, G.K. The Multidimensional Scale of Perceived Social Support. J. Pers. Assess. 1988, 52, 30–41. DOI: https://doi.org/10.1207/s15327752jpa5201_2
Rogers, J.; Wood, J.; McCandlish, R.; Ayers, S.; Truesdale, A.; Elbourne, D. Active versus expectant management of third stage of labour: The Hinchingbrooke randomised controlled trial. Lancet 1998, 351, 693–699. DOI: https://doi.org/10.1016/S0140-6736(97)09409-9
Begley, C.M.; Gyte, G.M.; Devane, D.; McGuire, W.; Weeks, A. Active versus expectant management for women in the third stage of labour. Cochrane Database Syst. Rev. 2011, 9, CD007412, Update in: Cochrane Database Syst Rev. 2015;3:CD007412. DOI: https://doi.org/10.1002/14651858.CD007412.pub3
Mehrabadi, A.; Hutcheon, J.A.; Lee, L.; Kramer, M.S.; Liston, R.M.; Joseph, K.S. Epidemiological investigation of a temporal increase in atonic postpartum haemorrhage: A population-based retrospective cohort study. BJOG Int. J. Obstet. Gynaecol. 2013, 120, 853–862. DOI: https://doi.org/10.1111/1471-0528.12149
Begley, C.M.; Gyte, G.M.; Devane, D.; McGuire, W.; Weeks, A. Active versus expectant management for women in the third stage of labour. Cochrane Database Syst. Rev. 2015, 2, CD007412, Update in: Cochrane Database Syst Rev. 2019 Feb 13;2:CD007412 DOI: https://doi.org/10.1002/14651858.CD007412.pub5
Bingham, D.; Jones, R. Maternal Death from Obstetric Hemorrhage. J. Obstet. Gynecol. Neonatal Nurs. 2012, 41, 531–539. DOI: https://doi.org/10.1111/j.1552-6909.2012.01372.x
Bell, A.F.; Erickson, E.N.; Carter, C.S. Beyond labor: The role of natural and synthetic oxytocin in the transition to motherhood. J. Midwifery Women’s Health 2014, 59, 35–42. DOI: https://doi.org/10.1111/jmwh.12101
Kenkel, W.M.; Yee, J.R.; Carter, C.S. Is Oxytocin a Maternal-Fetal Signaling Molecule at Birth? Implications for Development. J. Neuroendocrinol. 2014, 26, 739–749. DOI: https://doi.org/10.1111/jne.12186
Saxton, A.; Fahy, K.; Rolfe, M.; Skinner, V.; Hastie, C. Does skin-to-skin contact and breast feeding at birth affect the rate of primary postpartum haemorrhage: Results of a cohort study. Midwifery 2015, 31, 1110–1117. DOI: https://doi.org/10.1016/j.midw.2015.07.008
Matthiesen, A.-S.; Ransjo-Arvidson, A.-B.; Nissen, E.; Uvnas-Moberg, K. Postpartum Maternal Oxytocin Release by Newborns: Effects of Infant Hand Massage and Sucking. Birth 2001, 28, 13–19. DOI: https://doi.org/10.1046/j.1523-536x.2001.00013.x
Nissen, E.; Lilja, G.; Widström a, M.; Uvnäs-Moberg, K. Elevation of oxytocin levels early post partum in women. Acta Obstet. Gynecol. Scand. 1995, 74, 530–533. DOI: https://doi.org/10.3109/00016349509024384
Gimpl, G.; Fahrenholz, F. The oxytocin receptor system: Structure, function, and regulation. Physiol. Rev. 2001, 81, 629–683. DOI: https://doi.org/10.1152/physrev.2001.81.2.629
Handlin, L.; Jonas, W.; Petersson, M.; Ejdebäck, M.; Ransjö-Arvidson, A.B.; Nissen, E.; Uvnäs-Moberg, K. Effects of sucking and skin-to-skin contact on maternal ACTH and cortisol levels during the second day postpartum-influence of epidural analgesia and oxytocin in the perinatal period. Breastfeed. Med. 2009, 4, 207–220. DOI: https://doi.org/10.1089/bfm.2009.0001
Lewis, M. An Investigation of the Effects of Pitocin for Labor Induction and Augmentation on Breastfeeding Success. Open Access Senior Thesis, Scripps Research, La Jolla, CA, USA, 2012; pp. 1–109.
Feldman, R.; Gordon, I.; Zagoory-Sharon, O. Maternal and paternal plasma, salivary, and urinary oxytocin and parent-infant synchrony: Considering stress and affiliation components of human bonding. Dev. Sci. 2011, 14, 752–761. DOI: https://doi.org/10.1111/j.1467-7687.2010.01021.x
Gordon, I.; Zagoory-Sharon, O.; Leckman, J.F.; Feldman, R. Oxytocin and the development of parenting in humans. Biol. Psychiatry 2010, 68, 377–382. DOI: https://doi.org/10.1016/j.biopsych.2010.02.005
Uvnäs-Moberg, K. Oxytocin may mediate the benefits of positive social interaction and emotions. Psychoneuroendocrinology 1998, 23, 819–835. DOI: https://doi.org/10.1016/S0306-4530(98)00056-0
Sabati, S.Y.A.; Mousa, O. Effect of Early Initiation of Breastfeeding on the Uterine Consistency and the Amount of Vaginal Blood Loss during Early Postpartum Period. Nurs. Prim. Care 2019, 3, 2–7. DOI: https://doi.org/10.33425/2639-9474.1108
Irons, D.W. A simple alternative to parenteral oxytocics for the third stage of labor. Int. J. Gynecol. Obstet. 1994, 46, 15–18. DOI: https://doi.org/10.1016/0020-7292(94)90303-4
McNeilly, A.S.; Robinson, I.C.; Houston, M.J.; Howie, P.W. Release of oxytocin and prolactin in response to suckling. Br. Med. J. 1983, 286, 257–259 DOI: https://doi.org/10.1136/bmj.286.6361.257
Abedi, P.; Jahanfar, S.; Namvar, F. Nipple stimulation or breastfeeding for preventing postpartum haemorrhage in the third stage of labour. Cochrane Database Syst. Rev. 2013, 11, 1–13. DOI: https://doi.org/10.1002/14651858.CD010845
Chua, S.; Arulkumaran, S.; Lim, I.; Selamat, N.; Ratnam, S.S. Influence of breastfeeding and nipple stimulation on postpartum uterine activity. Br. J. Obstet. Gynaecol. 1994, 101, 804–805. DOI: https://doi.org/10.1111/j.1471-0528.1994.tb11950.x
Moore, E.R.; Bergman, N.; Anderson, G.C.; Medley, N. Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst. Rev. 2016, 11, CD003519. DOI: https://doi.org/10.1002/14651858.CD003519.pub4
Ludington-hoe, S.M. Thirty Years of Kangaroo Care Science and Practice. Neonatal Netw. 2011, 30, 291–303. DOI: https://doi.org/10.1891/0730-0832.30.5.291
Kostandy, R.R.; Ludington-Hoe, S.M. The evolution of the science of kangaroo (mother) care (skin-to-skin contact). Birth Defects Res. 2019, 111, 1032–1043. DOI: https://doi.org/10.1002/bdr2.1565
Moore, E.; Anderson, G.C.; Bergman, N. Early skin-to-skin contact for mothers and their healthy newborn infants. Cochrane Database Syst. Rev. 2007, 18, CD003519, Update in: Cochrane Database Syst Rev. 2012;5:CD003519. DOI: https://doi.org/10.1002/14651858.CD003519.pub2
Jonas, K.; Johansson, L.M.; Nissen, E.; Ejdebäck, M.; Ransjö-Arvidson, A.B.; Uvnäs-Moberg, K. Effects of intrapartum oxytocin administration and epidural analgesia on the concentration of plasma oxytocin and prolactin, in response to suckling during the second day postpartum. Breastfeed. Med. 2009, 4, 71–82. DOI: https://doi.org/10.1089/bfm.2008.0002
Đorđević, G.; Jovanović, B.; Đorđević, M. An early contact with the baby: Benefit for the mother. Med. Pregl. 2008, 61, 576–579. DOI: https://doi.org/10.2298/MPNS0812576D
Moore, E.R.; Anderson, G.C. Randomized Controlled Trial of Very Early Mother-Infant Skin-to-Skin Contact and Breastfeeding Status. J. Midwifery Women’s Health 2007, 52, 116–125. DOI: https://doi.org/10.1016/j.jmwh.2006.12.002
Geller, S.E.; Adams, M.G.; Kelly, P.J.; Kodkany, B.S.; Derman, R.J. Postpartum hemorrhage in resource-poor settings. Int. J. Gynecol. Obstet. 2006, 92, 202–211. DOI: https://doi.org/10.1016/j.ijgo.2005.12.009
Saxton, A.; Fahy, K.; Skinner, V.; Hastie, C. Effects of immediate skin to skin contact and breastfeeding after birth on postpartum haemorrage (PPH) rates: A cohort study. Women Birth 2013, 26, S16–s17. DOI: https://doi.org/10.1016/j.wombi.2013.08.268
Johnston, C.; Campbell-Yeo, M.; Disher, T.; Benoit, B.; Fernandes, A.; Streiner, D.; Inglis, D.; Zee, R. Skin-to-skin care for procedural pain in neonates. Cochrane Database Syst. Rev. 2017, 2, CD008435. DOI: https://doi.org/10.1002/14651858.CD008435.pub3
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