Antioxidant and hepatoprotective activities of Pongamia pinnata (PP) Linn. leaves on anti-tubercular medicines (isoniazid & rifampin) induced hepatotoxicity in Wistar rats

Samba Siva Raju Derangula; N. S. Muthiah; Byna Jayachandra Babu; H. S. Somashekar; E. Sukumar; K. Prabhu

doi:10.53730/ijhs.v6nS1.4940

Authors

Samba Siva Raju Derangula Ph.D. Scholar, Bharath Institute of Higher Education & Research, Selaiyur, Chennai, Tamilnadu, India
N. S. Muthiah Professor, Department of Pharmacology, Sree Balaji Medical College & Hospital, Chrompet, Chennai, Tamilnadu, India
Byna Jayachandra Babu Assistant Professor, Department of Pharmacology, Ananta Institute of Medical Sciences & Research Centre, Rajasamand, Rajasthan, India
H. S. Somashekar Professor & Head, Department of Pharmacology, Viswabharathi Medical College & Hospital, Kurnool, Andhra Pradesh, India
E. Sukumar Ex- Dean of Research, Saveetha Institute of Medical & Technical Sciences, Chennai, Tamilnadu, India
K. Prabhu Associate Professor, Department of Anatomy, Sree Balaji Medical College & Hospital, Chrompet, Chennai, Tamilnadu, India

Keywords:

antioxidant parameters, anti-TB medicines, hepatoprotective activity, liver biomarkers, Pongamia pinnata

Abstract

Objectives: -The goal of this study was to see if an aqueous extract of Pongamia Pinnata Linn. (APP) leaves could protect against the hepatotoxicity caused by anti-TB medications (ATM). Methods: -In order to cause hepatotoxicity in rats, anti-tubercular medications were utilised. Silymarin (100 mg/kg p.o.) be present utilised by means of the control medication. For 21 days, an aqueous extract of Pongamia Pinnata Linn. leaves (200 & 400 mg/kg p.o.) was given with anti-TB medicines given one hour before to the aqueous extract. Results: -Biomarker enzymes found in the liver are SGPT, SGOT, ALP, Total Bilirubin & total cholesterol remained raised on anti-TB medicines management. The management of aqueous extract of Pongamia Pinnata Linn.leaves200 mg/kg & 400 mg/kg with anti - TB medicines were considerably decreased biomarker enzymes found in the liver. Antioxidant factors like Super Oxide Dismutase (SOD), Glutathione(GSH), Catalase(CAT), Glutathione Peroxidase (GPx)& Glutathione Reductase(GRx) were inhibited and improved ThioBarbituric Acid Reactive Substances (TBARs)points in anti-TB medicines administration then returned these antioxidant points in the management of aqueous extract of Pongamia Pinnata Linn. Leavesatadosageof 200mg/kg& 400mg/kg. Conclusion: - According to the findings of this research, Pongamia Pinnata Linn. leaves have a protective consequence against hepatotoxicity caused through anti-TB medicines.

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