Attenuation of paracetamol induced hepatotoxicity by albizia odoratissima in rats

Jayachandrababu Byna; S. Rajaram; Kanala Somasekhar Reddy; Samba Siva Raju Derangula; S. Nathiya; Siva Sankari

doi:10.53730/ijhs.v6nS2.5173

Attenuation of paracetamol induced hepatotoxicity by albizia odoratissima in rats

https://doi.org/10.53730/ijhs.v6nS2.5173

Authors

Jayachandrababu Byna
jcpharmacology11@gmail.com
Ph. D research scholar, Department of Pharmacology, VMKV medical college, Vinayaka Missions Research Foundation (Deemed to be University), Ariyanoor, Salem-636308
S. Rajaram Professor, Department of Pharmacology, VMKV medical college, Vinayaka Missions Research Foundation (Deemed to be University), Ariyanoor, Salem-636308
Kanala Somasekhar Reddy Associate Professor and Head, Department of Pharmacology, Raghavendra Educational and Rural Development Society (RERDS), RIPER campus, Chiyyedu post, Anantapuramu – 515 721
Samba Siva Raju Derangula Assistant professor, Department of Pharmacology, ViswaBharathi Medical College and Hospital, Kurnool – 518467
S. Nathiya Reader and Head, Department of Pharmacology, Sri Ramakrishna dental college and hospital, Coimbatore – 641001
Siva Sankari Professor, Department of Pharmacology, VMKV medical college, Vinayaka Missions Research Foundation (Deemed to be University), Ariyanoor, Salem-636308

Keywords:

albizia odoratissima, hepatoprotective, paracetamol

Abstract

Hepatotoxicity is a common cause of severe metabolic disorders and even death. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic, and it produces acute liver damage if administrated in excess. Since the conventional treatment of liver diseases is associated with a wide range of adverse effects, botanical agents are commonly used. In this study we examined the therapeutic effect methanolic extract of bark of Albizia Odoratissima on paracetamol induced hepatotoxicity in rats.A total of 30 animals were randomly divided into five groups, and each group consisted of six animals and received the below mentioned treatment for the period of 21 days. Group I (Normal group): Received vehicle only. Group II (Negative group): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally. Group III (Test group -I): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally and Methanolic extract of bark of Albizia Odoratissima at dose of 250 mg/kg orally. Group IV (Test group – II): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally and Methanolic extract of bark of Albizia Odoratissima at dose of 500 mg/kg orally: PCM + MEAO (250mg/kg).

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Published

29-03-2022

How to Cite

Byna, J., Rajaram, S., Reddy, K. S., Derangula, S. S. R., Nathiya, S., & Sankari, S. (2022). Attenuation of paracetamol induced hepatotoxicity by albizia odoratissima in rats. International Journal of Health Sciences, 6(S2), 1676–1685. https://doi.org/10.53730/ijhs.v6nS2.5173

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Issue

Vol. 6 No. S2 (2022)

Section

Peer Review Articles

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