Attenuation of paracetamol induced hepatotoxicity by albizia odoratissima in rats
Keywords:
albizia odoratissima, hepatoprotective, paracetamolAbstract
Hepatotoxicity is a common cause of severe metabolic disorders and even death. Paracetamol (acetaminophen) is widely used as an antipyretic and analgesic, and it produces acute liver damage if administrated in excess. Since the conventional treatment of liver diseases is associated with a wide range of adverse effects, botanical agents are commonly used. In this study we examined the therapeutic effect methanolic extract of bark of Albizia Odoratissima on paracetamol induced hepatotoxicity in rats.A total of 30 animals were randomly divided into five groups, and each group consisted of six animals and received the below mentioned treatment for the period of 21 days. Group I (Normal group): Received vehicle only. Group II (Negative group): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally. Group III (Test group -I): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally and Methanolic extract of bark of Albizia Odoratissima at dose of 250 mg/kg orally. Group IV (Test group – II): Received the Paracetamol (PCM) at dose of 3g/kg body weight orally and Methanolic extract of bark of Albizia Odoratissima at dose of 500 mg/kg orally: PCM + MEAO (250mg/kg).
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